Aggressive Disease
A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas
... Background: Amplified centrosomes are widely recognized as a hallmark of cancer. Although supernumerary centrosomes would be expected to compromise cell viability by yielding multipolar spindles that results in death- ...
11
Primary malignant melanoma of the esophagus: a rare and aggressive disease
... This classification differentiates adequately the prognosis, T3 having a considerably better prognosis than T4, and emphasizes the aggressive nature of melanoma compared to adenocarcinoma and squamous cell ...
7
Impact of Genotyping on Outcome of Prostatic Biopsies: A Multicenter Prospective Study
... Single nucleotide polymorphisms (SNPs) have been associated with prostate cancer (PCa) risk and tumor aggressiveness in ret- rospective studies. To assess the value of genotyping in a clinical setting, we evaluated the ...
5
ATAD2 overexpression links to enrichment of B-MYB- translational signatures and development of aggressive endometrial carcinoma
... for aggressive endometrial cancer, such as high FIGO stage and high grade, non-endometrioid type, and loss of hormone receptors AR, PR and ...with aggressive disease ...with aggressive ...
13
A Seventeen-year-old Boy Patient with Lupus Nephritis as a Complication of Systemic Lupus Erythematosus (SLE) at Sanglah General Hospital, Bali, Indonesia: a Case Report
... Background: The systemic lupus erythematosus (SLE) is an autoimmune disease with various clinical manifestations. SLE indicated by the presence of autoantibodies to the nucleus components and immune complex ...
6
Adult T-cell leukemia/lymphoma in the Caribbean cohort is a distinct clinical entity with dismal response to conventional chemotherapy
... Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive disease caused by human T-cell lymphotropic virus type 1 that predominantly affects Japanese and Caribbean populations. Most studies have ...
10
Effects of a novel Nodal-targeting monoclonal antibody in melanoma
... more aggressive disease, and targeting Nodal in aggressive cancer cells leads to reduced cell proliferation and tumor growth both in vitro and in vivo [20, ...its aggressive behavior, this 3D1 ...
16
Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers?
... and disease aggressiveness does not imply non-existence of such genetic variants in the ...with aggressive disease should involve a case- case design contrasting patients with more and less ...
7
Investigating the Effect of Aging and Time on the Fate and Transport of Lead in Artificially Contaminated Tropical soils
... with aggressive disease features, such as a faster-running clock (high ...heterogeneous disease in terms of gene expression profiles [15, 16], and KAMS may help to discriminate between clinically ...
209
Crohn’s disease in a developing African mission hospital: a case report
... on disease severity, lo- cation of disease, and subtype of disease (that is, inflam- matory, stricturing, or ...for aggressive CD and who may require earlier and more ag- gressive ...for ...
8
A study of patients with aggressive multiple sclerosis at disease onset
... identify aggressive disease early, in order not to potentially lose this ...of disease course, we selected a set of criteria utilizing early clinical features and MRI findings that can be easily ...
6
Risk indicators of aggressive periodontitis in a Jordanian population
... multifactorial disease characterized by attachment and bone loss around ...the disease are influenced by the interaction of genetic, microbial and environmental fac- tors such as dental plaque (biofilm), ...
7
Safety and efficacy of denosumab in the treatment of pulmonary metastatic giant cell tumor of bone
... Results: All patients experienced chest pain relief in the first month of treatment. Three patients showed partial response. Four patients got stable disease after denosumab treatment. Adverse events included one ...
6
Higher gene expression variability in the more aggressive subtype of chronic lymphocytic leukemia
... CLL patients showing fewer mutations in this region, defined as U-CLL (‘unmutated’ CLL), have a worse prog- nosis compared to M-CLL (‘mutated’ CLL) patients, who show a larger number of mutations in the IgVH gene re- ...
12
Trends in Susceptibility to Aggressive Periodontal Disease
... However, the new nomenclature decreases granularity in classifications of periodontitis, which is unfortunate given that certain forms of periodontitis may be better distinguished etiologically with higher levels of ...
5
The role of surgical margins in atypical Lipomatous Tumours of the extremities
... The classification of well-differentiated lipomatous tu- mours of the extremity and the trunk wall was clarified in the last edition of the WHO manual in 2013 [3]. The term “Atypical Lipoma” is well defined and accepted. ...
7
Comparison of narcissism dimensions in aggressive and non-aggressive girls
... ﻪﻣﺎﻨﺸﺳﺮﭘ ﻪﺑ ﺎﻫ ﻤﻜﺗ ﺺﻗﺎﻧ رﻮﻃ ﺎـﻬﻧآ زا يداﺪـﻌﺗ ،دﻮﺑ هﺪﺷ ﻞﻴ.. ﻲﻳﺎﻬﻧ ﻪﻧﻮﻤﻧ داﺪﻌﺗ ﺐﻴﺗﺮﺗ ﻦﻳﺪﺑ ،ﺪﻧﺪﺷ ﻪﺘﺷاﺬﮔ رﺎﻨﻛ 531 ﺮﻔﻧ ﺪﺷ. ﻪﻣﺎﻨﺸﺳﺮﭘ ﺶﻧاد ﻦﻴﺑ رد ﺮﻈﻧ درﻮﻣ يﺎﻫ ﻪﺑ نازﻮﻣآ ترﻮﺻ ﺪﺷ هداد ﺎﻬﻧآ ﻪ[r] ...
6
In-depth investigation of the molecular pathogenesis of bladder cancer in a unique 26-year old patient with extensive multifocal disease: a case report
... To our knowledge there are only few studies that investigated the molecular changes in bladder tumors of young patients. Identifying the molecular pathways of these tumors could define a subset of patients and redir- ect ...
7
Clinical Diagnosis and Management of Respiratory Distress in Preterm Neonates: Effect of Participation in a Controlled Trial
... This could have influenced the clinical manage- ment of newborns with respiratory distress, resulting in more liberal diagnosis of hyaline membrane disease and more aggressive initial tr[r] ...
6
miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies
... the disease in the mice was indolent with only 20% of mice dying of leukaemia at old ...in aggressive CLL disease [152] provided an innovative tool for prognosis stratification of CLL patients and ...
25