AIRE/C
Schaller, Claudia Eva Maria (2010): The Autoimmune Regulator (AIRE) and the Early Wave of Apoptosis in Spermatogenesis. Dissertation, LMU München: Fakultät für Biologie
... that AIRE is involved in the expression of peripheral-tissue antigens (PTA) by mTECs in the ...and Aire-deficient mice, which showed that AIRE indeed promotes transcription of a large number of ...
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NF κB2 is required for the establishment of central tolerance through an Aire dependent pathway
... follows: Aire forward, 5′-CCAGT- GAGCCCCAGGTTAAC-3′; reverse, 5′-GACAGCCGTCACAACAGATGA-3′; probe, 5′-FAM-TCACCTCCGTCGTGGCACACG-TAMRA-3′; Ins1 forward, 5′-CTTCAGACCTTGGCGTTGGA-3′; reverse, 5′-ATGCTGGTGCAGCACT- ...
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Human skin cells support thymus independent T cell development
... www.cgi). AIRE primers were as follows: forward, 5′-GATGACCTG- GAGTCCCTTCT-3′; reverse, ...5′-CTCATCAGAGCTGCATGTCC-3′. AIRE primers were common to the 3 isomers of human ...
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Aire controls gene expression in the thymic epithelium with ordered stochasticity
... dephosphorylated by adding 4 µL of a mix containing 2µL of 10X Antarctic Phosphatase Reaction Buffer, 1µL of Antartic phosphatase (5U/µL stock, NEB M0289) and 1µL of RNAseOut to 16µL of each aRNA pool and incubating at ...
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Les noms d’humains en aire : essai de classification
... dénotent, comme le dit Lecolle (2012), « un rassemblement des membres sur un certain mode […] lien fonctionnel, social, politique ». Gross (2011, 74) range ces N collectifs sous le label d’« instances officielles » du ...
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AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma
... vaccinated strain 1 or untreated with vaccinated strain 2 groups showed the existence of highly significance statistical differences (P < 0.0001). B.-E. Frequency and cytotoxic activity of MAGEB2 256-264 ...
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AIRE acetylation and deacetylation: effect on protein stability and transactivation activity
... the C-terminal region [4]. AIRE PHDs are multi- functional domains, with transactivation and repression activity ...of AIRE was initially described as an HSR (Homogenously Staining Region) domain; ...
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Association of the AIRE gene with susceptibility to rheumatoid arthritis in a European population: a case control study
... the AIRE protein; hence, other non-synonymous SNPs could con- tribute to the ...of AIRE are lower for the rs878081C risk allele ...the AIRE gene in the thymus, contributing to the maintenance of ...
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LYN and AIRE mediated tolerance checkpoint defects synergize to trigger organ specific autoimmunity
... Antigen presentation assays. Lymph node DCs were enriched by binding to anti-CD11c magnetic beads (Miltenyi), eluted, and plat- ed at serial dilutions in 96-well round-bottom tissue culture plates (Costar) and incubated ...
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Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
... The G228W-knockin mouse expresses Aire protein. (A) Schematic of the first 8 exons of targeted G228W allele. The asterisk marks the site of the missense mutation. Arrowheads flanking the neo cassette represent ...
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Estrogen mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases
... sion in immune cells after puberty in mice is mediated through the estrogen pathway (75–77). These estrogen effects are medi- ated through 2 nuclear receptors, ERα and ERβ, both expressed at various levels in most immune ...
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Differential Role of Sp100 Isoforms in Interferon-Mediated Repression of Herpes Simplex Virus Type 1 Immediate-Early Protein Expression
... B, C, and HMG, but not A, suppress ICP0 promoter activity and that the suppressive effect of the Sp100B isoform depends on an intact SAND (Sp100, AIRE-1, NucP41/75, and DEAF-1) domain, since mutation in ...
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The AIRE-230Y Polymorphism Affects AIRE Transcriptional Activity: Potential Influence on AIRE Function in the Thymus
... The pcDNA5/FRT/P(GC)AIRE-firefly luciferase construct was first methylated using the M. SssI CpG methyltransferase (N.E.B) and then subjected to the bisulphite conversion process and subsequent DNA clean-up using ...
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Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases
... 22 more authors 2015 Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases.. Reuse Unless indicated otherwise, fulltext items [r] ...
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Alteration of intra pancreatic target organ specificity by abrogation of Aire in NOD mice
... of AIRE in regulating target-organ specificity remain ...which Aire has been ...in Aire-deficient NOD mice, and this alteration of intra-pancreatic target-organ specificity was associated with ...
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Epidemiology and health related quality of life in hypoparathyroidism in Norway.
... Causes of hypoparathyroidism Cause Gene when indicated Reference Postsurgical and/or following radioactive iodine thyroid ablation Autoimmune Isolated Component of APS-1 AIRE/21q22.3 7, [r] ...
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Cutaneous vasculitis in patients with autoimmune polyendocrine syndrome type 1: report of a case and brief review of the literature
... Background: Autoimmune polyendocrine syndrome type 1, also known as autoimmune polyendocrinopathy- candidiasis-ectodermal-dystrophy, is a rare autosomal recessive disease due to pathogenic variants in the AIRE ...
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In search of quality indicators for Down syndrome healthcare: a scoping review
... Abbreviations ACSC: Ambulatory Care Sensitive Conditions; AIRE: Appraisal of Indicators Through Research and Evaluation; DS: Down syndrome; HEDIS: Healthcare Effectiveness Data and Infor[r] ...
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Reporting standards for guideline-based performance measures
... Similar principles apply to the composition of guideline- based PM groups as to clinical practice guidelines, in- cluding the consideration of conflicts of interest, but there is very little evidence for this rationale. ...
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Novel insight into Chronic Inflammatory Demyelinating Polineuropathy in APECED syndrome: molecular mechanisms and clinical implications in children
... Autoimmune polyendocrinopathy-candidiasis-ectodermal-dystrophy (APECED) is a rare primary immunodeficiency disorder typically caused by homozygous AIRE gene mutation. It is characterized by the association of ...
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