Airway Hyperreactivity
Diagnostic accuracy of methacholine challenge tests assessing airway hyperreactivity in asthmatic patients - a multifunctional approach
... Airway hyperreactivity (AHR) is a characteristic feature of bronchial asthma, and methacholine challenge testing (MCT) is well established to quantitate AHR in patients with unexplained symptoms such as ...
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CD4+ T helper cells engineered to produce latent TGF β1 reverse allergen induced airway hyperreactivity and inflammation
... attenuate airway inflammation, but minimize tissue ...reversed airway hyperreactivity and reduced airway inflamma- tion without inducing pulmonary ...
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Allergen specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation
... allergen-induced airway hyperreactivity in normal BALB/c ...this airway hyperreactivity, although Th1 cells migrated to the lungs as proved by fluorescence staining of lung sections with ...
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Effects of Diet Induced Mild Obesity on Airway Hyperreactivity and Lung Inflammation in Mice
... Purpose: Obesity has been suggested to be linked to asthma. However, it is not yet known whether obesity directly leads to airway hyperreactivity (AHR) or obe- sity-induced airway inflammation ...
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IL 13Rα2 and IL 10 coordinately suppress airway inflammation, airway hyperreactivity, and fibrosis in mice
... Development of persistent Th2 responses in asthma and chronic helminth infections are a major health con- cern. IL-10 has been identified as a critical regulator of Th2 immunity, but mechanisms for controlling Th2 ...
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Neuronal eotaxin and the effects of ccr3 antagonist on airway hyperreactivity and M2 receptor dysfunction
... Effect of CCR3 antagonist on antigen-induced airway hyperreactivity. To test the effect of signaling via CCR3 in antigen-induced airway hyperreactivity, we sensitized guinea pigs by i.p. ...
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Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity
... Infection with influenza A virus represents a major public health threat worldwide, particularly in patients with asthma. However, immunity induced by influenza A virus may have beneficial effects, particularly in young ...
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Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2
... Monocyte chemoattractant protein-1 (MCP-1, also known as CCL2) and its receptor, CCR2, have been the focus of intense interest due to increasing awareness of their association with debilitating human diseases, including ...
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IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice
... Severe asthma (SA) is a significant problem both clinically and economically, given its poor response to corticosteroids (CS). We recently reported a complex type 1–dominated (IFN-γ–dominated) immune response in more ...
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Nonatopic asthma: in vivo airway hyperreactivity adoptively transferred to naive mice by THY 1(+) and B220(+) antigen specific cells that lack surface expression of CD3
... to airway hyperreactivity (AHR), we studied an in vivo mouse model induced by the hapten picryl (trinitrophenyl) chloride ...and airway challenged subsequently with picryl sulfonic acid (PSA) antigen ...
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Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions
... the airway response to inhaled antigen is not ...on airway reactivity and response to antigen in 10 adult ragweed allergic rhinitis ...of airway reactivity to histamine and ragweed ...
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Assessment of airway hyperreactivity: comparison of forced spirometry and body plethysmography for methacholine challenge tests
... Specific airway resistance (sRaw), specific conductance (sGaw), airway resistance (Raw), conductance (Gaw) and intrathoraxic gas volume (ITGV) were recorded by body plethysmography (MasterScreen Body, ...
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C5 Modulates Airway Hyperreactivity and Pulmonary Eosinophilia during Enhanced Respiratory Syncytial Virus Disease by Decreasing C3a Receptor Expression
... expression in the lungs, our data add a new layer of complexity to the role of complement components in pulmonary disease and offer a new mechanistic explanation, which may comple- ment previous observations on the ...
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Chronic Cough in Children: A Manifestation of Airway Hyperreactivity
... Fifteen children who presented with chronic cough as an isolated manifestation of respiratory disease were evaluated for the presence of exercise-induced air- way hyperreactivity.. Pulmo[r] ...
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Requirements for Allergen-Induced Airway Hyperreactivity in T and B Cell-Deficient Mice
... As expected, T cell-deficient mice failed to develop lung inflammation and AH (8-11), and the role for Th2 cells predicted by the human studies was validated using anti-IL-4 and anti- IL[r] ...
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Effect of the sensitization to Dermatophagoïdes pteronyssinus on the inflammatory response and bronchoconstrictive of brown Norway rats
... an airway hyperreactivity, an infiltration of neutrophils, eosinophils, and lymphocytes in the bronchoalvelar lavage, all coupled with an increase cytokines IL17, IL5, IL4 and tissue remodeling ...
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Determining the role of ONZIN in immunity
... allergic airway studies with IL-5 deficient mice show that lack of this interleukin results in an elimination of airway hyperreactivity and lung ...allergic airway disease should be ...
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Viral induction of a chronic asthma phenotype and genetic segregation from the acute response
... with airway hyperreactivity and goblet cell hyperplasia lasting at least a year after complete viral clear- ...from airway inflammation and hyperreactivity despite similar viral infection ...
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Mitogenic effect of lysosomal hydrolases on bovine tracheal myocytes in culture
... As proliferation of respiratory smooth muscle cells may be directly related to the muscle contraction and airway hyperreactivity, we hypothesized lysosomal hydrolases released by airway [r] ...
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Aeroallergen induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL 4 and allergen specific immunoglobulins
... cells, or in mice deficient in MHC class II, indicating an essen- tial requirement for sensitization and a functional immune sys- tem (29, 30, 32, 34, 40, 41). In asthma, while it is clear that allergen-specific ...
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