Airway hyperresponsiveness (AHR)
Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice
... baseline airway hyperresponsiveness (AHR): in a 12-week clinical trial, anti-IL17A antibody treatment improved symptom scores only in the subgroup of patients who, in baseline pulmonary function ...
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Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response
... of airway inflammation, (b) the maintenance of airway hyperresponsiveness (AHR), and (c) sustainment of an ongoing airway response to allergen ...established airway inflammation ...
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Clinical implications of airway hyperresponsiveness in COPD
... on AHR in patients with ...“airway hyperresponsiveness” is not a MeSH term and is not recognized as an entry term for the MeSH “bronchial hyperreactivity”, which is the MeSH closest to the definition ...
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An open-label study examining the effect of pharmacological treatment on mannitol- and exercise-induced airway hyperresponsiveness in asthmatic children and adolescents with exercise-induced bronchoconstriction
... Airway hyperresponsiveness (AHR), a characteristic feature of asthma, is an abnormal increase in airflow limitation that follows exposure to a stimulus that would be innocuous in a healthy person ...
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Arsenic trioxide, a potent inhibitor of NF-κB, abrogates allergen-induced airway hyperresponsiveness and inflammation
... AHR, Airway hyperresponsiveness; ANOVA, One-way analysis of variance; APL, Acute promyelocytic leukemia; As 2 O 3 , Arsenic trioxide; ATRA, All-trans retinoic acid; BALF, Bronchoalveolar lavage ...
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Zinc supplementation alters airway inflammation and airway hyperresponsiveness to a common allergen
... allergic airway inflammation in our established mouse ...an airway response by sen- sitizing and challenging mice to GC frass on days 0, 7, and ...significant airway hyperresponsiveness to ...
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Pulmonary C Fibers Modulate MMP-12 Production via PAR2 and Are Involved in the Long-Term Airway Inflammation and Airway Hyperresponsiveness Induced by Respiratory Syncytial Virus Infection
... persistent airway inflammation and ...of airway inflammation and resistance; however, their role in persistent airway diseases after RSV is ...study. Airway inflammation and airway ...
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Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma
... Phosphatase and tensin homologue deleted on chromosome ten (PTEN) is part of a complex signal- ing system that affects a variety of important cell functions. PTEN blocks the action of PI3K by dephosphorylating the ...
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The contribution of L-selectin to airway hyperresponsiveness in chronic allergic airways disease
... of airway inflammation was assessed by examining leukocyte influx into bronchoalveolar lavage ...fluid. Airway remodeling changes were determined via histology and morphometric analysis of lung tissue ...
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Obesity can influence children’s and adolescents’ airway hyperresponsiveness differently
... induced airway distensibility and a reduction in peripheral airway diameter, which, over time, may perturb smooth muscle function thus increasing both airway obstruction and AHR ...smaller ...
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BMI can influence adult males’ and females’ airway hyperresponsiveness differently
... standing airway inflammation) represent persistent alterations ...variable AHR component is believed to relate to inflammatory airway events, which may vary and be influenced by numer- ous ...
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TNFα-blockade stabilizes local airway hyperresponsiveness during TLR-induced exacerbations in murine model of asthma
... understood. Airway hyperrespon- siveness (AHR) is closely related to the asthmatic exacer- bation [2, ...study AHR was evaluated in ovalbumin (OVA) mouse model of allergic ...lergic airway ...
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Role of Abl in airway hyperresponsiveness and airway remodeling
... of airway smooth muscle [1]. The pathological mechanisms that mediate airway smooth muscle hyperreactivity and AHR in asthma are not completely ...in airway tissues of the animal model of ...
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Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-/-mice
... investigating airway inflammation in aged sensitized and challenged mice are available and even less on airway ...the AHR observed in 6-month-old Cav1 -/- mice is inde- pendent of inflammation and ...
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Modulation of airway hyperresponsiveness by rhinovirus exposure
... While human models of RV infection are most rele- vant, ethical concerns and practical limitations exist where investigators have chosen to use animal models. Yin and Lomax [29] developed a murine model of RV infection ...
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Airway resistance at maximum inhalation as a marker of asthma and airway hyperresponsiveness
... with clinical status. It is possible that there could be important differences in the physiology of milder versus more severe asthma. Finally, the deep inhalations per- formed during the dosimeter protocol for ...
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Culture supernatant of adipose stem cells can ameliorate allergic airway inflammation via recruitment of CD4+CD25+Foxp3 T cells
... AHR: airway hyperresponsiveness; ASC sup: supernatant of ASCs; ASCs: adipose tissue stem cells; BALF: bronchoalveolar lavage fluid; con sup: control supernatant; ELISA: enzyme-linked immunosorbent ...
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Involvements of p38 MAPK and oxidative stress in the ozone-induced enhancement of AHR and pulmonary inflammation in an allergic asthma model
... including airway hyperresponsiveness (AHR), airway resistance (Raw), lung compliance (CL), inflammation in the airway lumen and lung parenchyma, the phosphorylation of p38 MAPK and heat ...
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Elevated serum OX40L is a biomarker for identifying corticosteroid resistance in pediatric asthmatic patients
... allergic airway inflammation ...Th2/Th17-mediated airway in- flammation and promotes airway hyperresponsiveness (AHR) ...enhance airway inflamma- tion in asthmatic ...
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Metabolic origins of childhood asthma
... in airway narrow- ing and thereby increased resistance, which may contrib- ute to airway hyperresponsiveness (AHR), a characteristic feature of asthma ...modifies AHR in children with ...
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