Akita mice
PubMedCentral-PMC5051822.pdf
... Ins2 Akita/+ mice showed that systemic and urinary oxidative stress markers significantly increased, whereas endogenous antioxidant capacity significantly decreased, when Lias gene expression levels was ...
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PubMedCentral-PMC5328608.pdf
... endothelial cells, and in retinas from aged Ins2 Akita mice. MiR200-b and its native flanking sequences were amplified and cloned into a pCAG-eGFP vector directed by the ubiquitous CAG promoter (namely ...
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Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production
... HHA+ mice by EHT1864 was also partial, though significant, suggesting that Rac-dependent NOX does not account for the entire ROS production (Figure ...HHA+ mice (Figure ...HHA+ Akita mice ...
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Uncovering the protective role of POLGD257A, a mitochondrial DNA mutator, on diabetes and obesity
... Polg-Akita mice. At 3 months of age, both Akita and Polg-Akita male mice exhibited all the symptoms normally associated with type 1 ...Polg-Akita mice began to show ...
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Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice
... including Akita mice, which harbor a heterozygous mutation in Ins2 (Ins2 WT/C96Y ), and leptin receptor–deficient (Lepr –/– ) mice, resulted in an increase in b cell mass and ameliorated ...in ...
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Senescence associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
... in mice that are simply Akita ...simply Akita diabetic mice is much less than in the double mutants, it is nevertheless more severe than that normally seen in most human insulin-dependent ...
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Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?
... in Akita mice, we compared the effects of the subcutaneous adminis- tration of exendin-4 [27–30] to those of ...in Akita mice ...wild-type mice (as well as insulin-deficient Wolfram ...
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Diabetic mouse models
... Akita mice develop diabetic symptoms, such as hy- perglycemia, polydipsia, and polyuria, soon after wean- ...male mice decreases gradually after about 25 weeks of age, and the rate at 52 weeks of age ...
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Adipose stem cells and their paracrine factors are therapeutic for early retinal complications of diabetes in the Ins2Akita mouse
... Ins2 Akita mice, the targeted enhancement of genes regulat- ing retinal inflammation and tissue modulation may be re- quired to restore normal neurovascular tissue structure ...
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Diabetic bladder dysfunction is associated with bladder inflammation triggered through hyperglycemia, not polyuria
... weeks). Akita mice on a C57BL/6 background (C57BL/6-Ins2Akita/J, stock number: 003548), and the wild type C57BL/6J strain (stock number: 000664) were purchased from Jackson labs and bred in the mouse ...
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Safety of domperidone in treating nausea associated with dihydroergotamine infusion and headache
... from Akita Biomedical, personal fees from Alder Biopharmaceuticals, grants and personal fees from Allergan, grants and personal fees from Amgen, personal fees from Avanir Pharma, personal fees from Cipla ...
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Crystallographic Analysis Reveals Octamerization of Viroplasm Matrix Protein P9-1 of Rice Black Streaked Dwarf Virus
... Crystallographic Analysis Reveals Octamerization of Viroplasm Matrix Protein P9-1 of Rice Black Streaked Dwarf Virus Fusamichi Akita,a Akifumi Higashiura,b Takumi Shimizu,a Yingying Pu,a[r] ...
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Pituitary directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function A model for human pituitary Rathke's cysts
... transgenic mice, the cuboidal lining epithelium of the ante- rior wall of Rathke’s cleft was ciliated ...transgenic mice contained a decreased number of aci- dophil cells and a variable number of cystic ...
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New ostracod (Crustacea) species of the genus Robertsonites from the Upper Pliocene Kuwae and Sasaoka formations, central and northeast Japan
... The Upper Pliocene Sasaoka Formation of the Machimura section of the Gojome area, Akita Prefecture, northeast Japan.. Valves large-sized, sub-elliptical, tapering pos- teriorly in latera[r] ...
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Cohort study of consistency between the compliance with guidelines for chemotherapy-induced nausea and vomiting and patient outcome
... the Akita university hospital antiemetic guidelines were outlined, we assessed the incidence of chemotherapy-induced nausea and vomiting using the antiemesis tool of the Multinational Association of Supportive ...
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Magnetization Process and Coercivity of Fe (Al, Ga) (P, C, B, Si) Soft Magnetic Glassy Alloys
... Department of Machine Intelligence and Systems Science, Faculty of Systems Science of Technology, Akita Prefectural University, Honjo 015-0055, Japan 2 Institute for Materials Research, [r] ...
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0e873f77015040a42db5e8151d26041c4f387605.pdf
... heterozygous Akita diabetogenic mutation expressing ⬃ 10, 50, 100, 200, and 300% normal Tgfb1 mRNA levels have recently been ...these mice, the severity of glomerulosclerosis and albuminuria is enhanced as ...
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Evaluation of CO2 emissions reductions by timber check dams and their economic effectiveness
... production process compared with alternative materials such as steel and aluminum [1], and its use as a substitute for other materials may thus contribute to alleviating global warming. Effectively utilizing a moderate ...
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Occurrence of changes in human rotavirus serotypes with concurrent changes in genomic RNA electropherotypes
... Although serotype 1 strains predominated in both Yamagata and Akita during the epidemic of 1986 to 1987, 27 of 61 44.3% rotavirus-positive specimens that were collected from over 20 loca[r] ...
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Molecular and Epidemiological Analyses of Human Adenovirus Type 7 Strains Isolated from the 1995 Nationwide Outbreak in Japan
... lated in 1995, including 12 strains isolated in Hiroshima City (HR/95), eight isolated in Nara Prefecture (NR/95), four iso- lated in Yamanashi Prefecture (YM/95), one isolated in Akita Prefecture (AK/95), and one ...
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