Akt and NF-κB pathways
Vascular endothelial cells facilitated HCC invasion and metastasis through the Akt and NF-κB pathways induced by paracrine cytokines
... the Akt, ERK, and NF-κB pathways, and further promotes the invasion of HCC cells ...of Akt and ERK in HCC cells in ...ERK pathways, as one of the complex signal events, may be ...
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Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice
... pro-inflammatory NF-κB, an initial step in type 2 DM evolution that contributes to both β-cell apoptosis and IR [32], and induces the release of inflammatory factors ...and Akt in succession ...PI3K/ ...
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Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes
... and NF-κB pathways in response to TLR-2 ligation (the major receptor activated by spirochetal lipo- proteins), the related cystatin Sialo L suppressed the production of IFN-β and attenuated the ...
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Bovine ephemeral fever virus triggers autophagy enhancing virus replication via upregulation of the Src/JNK/AP1 and PI3K/Akt/NF-κB pathways and suppression of the PI3K/Akt/mTOR pathway
... of Akt [5, ...of Akt at S477 and T479 by the cyclin-dependent kinase 2 (CDK2)/cyclin A com- plex enhances Akt activation by functionally compensat- ing for Akt S473 phosphorylation [7, ...
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Original Article UHMWPE wear particles and dendritic cells promote osteoclastogenesis of RAW264.7 cells through RANK-activated NF-κB/MAPK/AKT pathways
... p38MAPK, AKT, and NF-κB was inhibited specific ...p38MAPK, AKT, and NF-κB were analyzed by qPCR and/or Western ...p38MAPK, AKT, and NF-κB pathways, ...
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Original Article Endogenous SARI exerts oncogenic functions in human K562 leukemia cells by targeting the PI3K/Akt/mTOR and NF-κB signaling pathways
... anti-human Akt, anti- human p-Akt, anti-human CyclinA2, anti-human CyclinE1, and rabbit anti-human Caspase-8, anti-human PARP, anti-human CyclinD, anti- human CyclinB1, anti-human CyclinD2, anti- human ...
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Atractylenolide I modulates ovarian cancer cell mediated immunosuppression by blocking MD 2/TLR4 complex mediated MyD88/NF κB signaling in vitro
... and Akt pathways of EOC cells will probably become focused on an approach to combination immunotherapy that simultaneously intensify anti-tumor immune responses while reversing tumor immune sup- ...of ...
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Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes
... factor of mitochondrial apoptosis pathway. The Cyt c is released from injured mitochondria and triggers cyto- solic caspase-3 activation through formation of the cytochrome c/Apaf-1/caspase-9-containing complex ...
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Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways
... infection, NF-κB could translocate to the nucleus and then modulate the expression of downstream target genes that participate in a number of cellular functions, including cell prolif- eration, apoptosis, ...
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Original Article Curcumin regulates the proliferation and apoptosis of human oligodendroglioma cells through both the NF-κB and AKT pathways
... and AKT detected by western ...in NF-κB and AKT signal pathways, and that these properties could be enhanced effectively by liposomes containing curcumin ...
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Si Wu tang extract stimulates bone formation through PI3K/Akt/NF κB signaling pathways in osteoblasts
... Si-Wu-Tang (SWT), a Traditional Chinese Medicine (TCM) formula, is comprised of a combination of 4 herbs; Paeoniae, Angelicae, Chuanxiong, and Rehmanniae, and is widely used for the treatment of women’ s diseases such as ...
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Original Article Differences in gene expression profiles and signaling pathways in rhabdomyolysis-induced acute kidney injury
... signaling pathways upon rhabdo- myolysis-induced acute kidney injury ...upregulated pathways including the PI3K/Akt, MAPK, and NF-κB signaling ...the NF-κB, MAPK, ...
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CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways
... through pathways that are inde- pendent of p16. AKT and ERK signaling pathways are known to regulate cell proliferation and apoptosis, epi- thelial mesenchymal transition (EMT), tumor angiogen- esis ...
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Decreased SATB1 expression promotes AML cell proliferation through NF-κB activation
... biological pathways gene expression was more highly represented in HL-60 SATB1-shRNA cells versus HL-60-CTR ...in NF-κB, MAPK and PI3 K/Akt signal- ing ...
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Computational modelling of NF-κB activation by IL-1RI and its co-receptor TILRR, predicts a role for Cytoskeletal Sequestration of IκBα in inflammatory signalling.
... and Akt-induced anti-apoptotic signals. Selective activation of the pathways was validated by comparing model outputs with in vitro experi- ments including the TILRR mutants, as in Fig 4G, 4H, 4I, 4J, 4K, ...
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Original Article CXCR4 was involved in andrographolide inhibits atherosclerosis by inactivating the PI3K/AKT/NF-κB signaling pathway
... The inflammatory cytokines influences EC-SMC- MC and promotes atherosclerosis, and andro inhibits the EC-SMC-MC apoptosis by suppress- ing CXCR4 mediated inflammatory response, playing a cell protection role. All these ...
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NF κB determines localization and features of cell death in epidermis
... that NF-κB can oppose cell death trig- gered by Fas and TNFα ...of NF-κB subunits in epithelial cell death, normal human keratinocytes were transduced with retroviral expres- sion vectors for ...
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A systems biology approach to explore the dynamics and interactions of the NF-κB signalling pathway
... of NF-κB have failed to report a basal nuclear level (Ashall et ...nuclear NF-κB being interpreted as an artefact of this ...of NF-κB may simply be too low to detect using ...
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Review Article Molecular mechanisms of NF- B signaling pathway in the development and progression of esophageal carcinoma
... by NF-κB. In addition, the NF-κB- induced ICAM-1 can promote the transendothe- lial migration of cell in EAC, thus enhancing the metastatic potential ...al., NF-κB inhibition ...
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Cycling hypoxia induces chemoresistance through the activation of reactive oxygen species mediated B cell lymphoma extra long pathway in glioblastoma multiforme
... stimulates NF-κB signaling, resulting in a B-cell lymphoma extra-long (Bcl- xL)-mediated resistance to drug-induced cell death ...[18]. NF-κB can bind directly to Bcl-xL promoter to regulate ...
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