Akt and p Akt
Expression and significance of CD44 and p AKT in pancreatic head cancer
... phosphorylated AKT (p-AKT) [5]. p-AKT phosphorylates multiple proteins implicated in cellular processes leading to induction of cell survival and inhibition of ...
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The different radiosensitivity when combining erlotinib with radiation at different administration schedules might be related to activity variations in c-MET-PI3K-AKT signal transduction
... After irradiation and/or erlotinib treatment, the C-MET-, p-C-MET-, AKT-, and p-AKT-expression levels in the A973 cells were determined by Western blot. The Western blot treatment groups were ...
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Prognostic significance of AKT/mTOR signaling in advanced neuroendocrine tumors treated with somatostatin analogs
... Statistical analysis was done with the software SPSS (Statistical Package for the Social Sciences) version 17.0 (IBM Corporation, Armonk, NY) and GraphPad Prism 5.03 (GraphPad Software, Inc, La Jolla, CA). Comparison of ...
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Overexpression of <em>PI3K p110α</em> contributes to acquired resistance to MET inhibitor, in MET-amplified SNU-5 gastric xenografts
... of p-MET and p-ERK protein levels were completely inhibited when both models were exposed to ...of p-AKT and p-S6 were only observed in PHA665752-resistant tumor tissues even after ...
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Toxicity Induced by Madopar (l-DOPA) during Curing Parkinson’s Disease by Inhibiting Mitochondrial Function and AKT Pathway
... PI3Kinase (PI3K) is involved in the inhibition of apopto- sis, and Akt is a critical mediator that regulates this PI3K- dependent neuronal cell survival responses. ROS can inhibit the activity of PI3K and inhibit ...
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Original Article Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer
... TGF-α, P-AKT and PTEN in the genesis of non-small cell lung cancer ...and P-AKT by the use of specific antibody through immunohistochemistry as directed by the manufacturer, and detected PTEN ...
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The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis
... higher p-mTOR-positive rate than females (66% vs 27%, P = ...32%, P = 0.063) and p-AKT-positive rate (68% vs 37%, P = ...41%, P = 0.023) and lower p-mTOR-positive ...
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The PI3K-AKT-mTOR pathway activates recovery from general anesthesia
... Moreover, at the beginning of anesthesia, the general anesthesia drugs widely distributed in the neural sites of brain, which may inhibit the brain functions of conscious, nervous motion, learning and memory and so on, ...
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Original Article Evaluation of AKT phosphorylation and PTEN loss and their correlation with the resistance of rituximab in DLBCL
... PTEN/PI3K/ AKT pathway in DLBCL patients who are resistant or sensitive to rituximab treatment, and investigate the potential clinical application of these ...of p-AKT, PTEN, and Ki-67 protein in 48 ...
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<p>NSD2 Promotes Renal Cancer Progression Through Stimulating Akt/Erk Signaling</p>
... Total protein from transfected cells was obtained using Whole Cell Lysis Assay (Keygen Biotech, China). Protein samples were subjected to SDS – PAGE and trans- ferred to PVDF membranes (Millipore, USA). After blocking ...
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Gemcitabine resistance in breast cancer cells regulated by PI3K/AKT-mediated cellular proliferation exerts negative feedback via the MEK/MAPK and mTOR pathways
... of p-ERK, p-AKT, mTOR, p-mTOR, and p-P70S6K, and reduced expression of p-P38 and LC3-II (the marker of autophagy) in 231/Gem as compared to control ...and p-AMPK can be ...
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COL11A1 confers chemoresistance on ovarian cancer cells through the activation of Akt/c/EBPβ pathway and PDK1 stabilization
... proteins were degraded more rapidly in shCOL11A1 cells than in shcontrol cells (Fig. 5D). The results of a cycloheximide pulse-chase experiment indicated that the half-life of PDK1 protein was significantly lower in ...
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<p>Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas</p>
... MAPK, AKT is another signaling pathway that plays a critical role in the progression of uterine leio- ...And p-AKT expression was signi fi cantly increased in uterine leiomyomas, and the cell ...
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PBX3 is associated with proliferation and poor prognosis in patients with cervical cancer
... Notes: (A) Western blotting analysis of PBX3, total aKT (t-aKT), and phosphorylated aKT (p-aKT), in hela and siha cells transfected with empty shrnavector and with PBX3silenced. gaPDh ...
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Phosphorylation and inactivation of PTEN at residues Ser380/ Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway
... anti- Akt (ab8805; 1:400), anti-p-Akt (Ser473) (ab66138; 1:400), anti-p-Akt (Thr308) (ab38449; 1:200), anti-Bad (ab32445; 1:1000), and anti-p-Bad (Ser136) (ab28824; 1:1000) ...
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Mitomycin C treatment induces resistance and enhanced migration via phosphorylated Akt in aggressive lung cancer cells
... To repair chemotherapeutic agent-induced DNA damage, cancer cells can activate the NER, HR, TLS, and FA repair pathways, which cooperate with each other [55]. NER may be defective in CL1-0 and CL1-5 cells owing to the ...
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Original Article shRNA-mediated silencing of PKHD1 gene promotes proliferation, migration and invasion of human intrahepatic cholangiocarcinoma HuCCT-1 cells
... PI3K, Akt, p-Akt, and NF-κB expression in LV3-PKHD1 transfected HuCCT-1 cells as compared to that in the LV3NC-transfected and nontransfected cells (P < ...
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Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway
... total AKT, p-AKT (Ser473), p-AKT (Thr308), IκBα, p-IκBα (Ser32), NF-κB p65, p-NF-κB (Ser536) and proliferating cell nuclear anti- gen (PCNA) were obtained from Cell ...
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Original Article EBV-LMP1 regulating AKT/mTOR signaling pathway and WWOX in nasopharyngeal carcinoma
... NPC. AKT/mTOR signaling pathway was considered the primary pathway of cancer cell ...survival. AKT/mTOR pathway and WWOX had been found to be closely ...the AKT/mTOR signaling pathway and WWOX ...of ...
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Original Article microRNA-218 promotes sensitivity of human pancreatic cancer cells to gemcitabine through HMGB1 and the PI3K/Akt pathway
... of AKT and phospho-AKT (p-AKT) in GEM-induced PANC-1 cells as well as on cell viability were examined using the phosphatidylinositol-3-kinase (PI3K) pathway inhibitor, wortmannin, with western ...
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