Akt signaling
Functional role of AKT signaling in bovine early embryonic development: potential link to embryotrophic actions of follistatin
... of AKT inhibitor treated em- bryos were ...of AKT inhibitor III on early cleavage, total cleavage and development to the 8- to 16-cell stage and partially rescued development to the blastocyst ...that ...
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Original Article NPTX1 promotes tumorigenesis of glioma through augmentation of IRS-1/PI3K/AKT signaling
... the Akt/PKB pathway, which plays a piv- otal role in regulation of various biological processes, including apoptosis, proliferation, differentiation, and intermediary ...of Akt (Akt-kd) blocked ...
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<p>MicroRNA-145 inhibits growth of laryngeal squamous cell carcinoma by targeting the PI3K/Akt signaling pathway</p>
... Tumor development is a complex process involving multiple factors and stages, typically arising from the accumulation of multiple gene mutations. As a result, the etiology and biological mechanisms underlying the prolif- ...
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<p>Guava Leaf Extract Attenuates Insulin Resistance via the PI3K/Akt Signaling Pathway in a Type 2 Diabetic Mouse Model</p>
... Natural products have a long history of being used as anti- diabetic drugs. Previous studies have reported that berberine extracted from Coptis chinensis Franch can increase insulin- induced IRS-1 tyrosine ...
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<p><em>WFDC2</em> contributes to epithelial–mesenchymal transition (EMT) by activating AKT signaling pathway and regulating MMP-2 expression</p>
... PI3K-AKT signaling, leading to the downregula- tion of MMP-2 and declined the invasion and metastasis of ovarian cancer cells, while overexpression of WFDC2 entirely reverses these ...PI3K-AKT ...
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treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway
... Multiple distinct pro-autophagic stimuli, including nutrient deprivation, induce Mdm2-dependent proteasomal degradation of p53 [51]. Recently, p53 has also emerged as a critical regulator of cell metabolism and ...
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<p>Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas</p>
... MAPK, AKT is another signaling pathway that plays a critical role in the progression of uterine leio- ...and AKT signaling pathway was related with mifepristone inhibition on cell ...
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Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice
... AKT signaling plays an important role in the LPS-induced proinflammatory response ...[35]. AKT is the main kinase in the signal transduction pathway predom- inantly responsible for the production and ...
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A signaling pathway AKTing up in schizophrenia
... kinase AKT (also known as PKB) signaling pathway has been associated with several human diseases, including schizo- ...impaired AKT signaling affects neuronal connectivity and neuromodulation ...
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Gemcitabine resistance in breast cancer cells regulated by PI3K/AKT-mediated cellular proliferation exerts negative feedback via the MEK/MAPK and mTOR pathways
... (MEK)/MAPK signaling pathways were activated through elevated expression of phosphorylated (p)-extracellular signal-regulated kinase (ERK), p-AKT, mTOR, p-mTOR, p-P70S6K, and reduced expression of p-P38 and ...
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The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells
... by Akt. Such a downstream molecule of the PI3K/Akt pathway is the serine/threonine protein kinase GSK3β that phosphorylates a broad range of substrates, including several transcription ...PI3K/ Akt ...
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AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development
... that AKT signaling may play an important role in cerebral cortical ...phosphorylated AKT (P-Ser-473) in dividing cortical neural precursors suggestive of active AKT signaling ...of ...
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Original Article DNA methylation profiles in the hippocampus of an Alzheimer’s disease mouse model at mid-stage neurodegeneration
... (AKT) signaling and focal adhesion sig- naling ...adhesion signaling pathway (Figure 5, marked with ...PI3K/Akt signaling pathway ...
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Vol 68, No 3 (2016)
... PI3K/Akt signaling has been implicated in differentiation of cells such as skeletal muscle cells, adipocytes, osteoblasts, chondrocytes and myoblasts ...PI3K/Akt signaling pathway in order to ...
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PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis
... study, AKT signaling was found to be es- sential for maintaining HF-MSC proliferation by upregulat- ing cyclin D1 and downregulating p16 and p21 ...of AKT also improve re- programming ...of ...
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Original Article RNAi screening with shRNAs against histone methylation-related genes reveals determinants of sorafenib sensitivity in hepatocellular carcinoma cells
... and AKT signaling (Figure 3), well-known signaling essential for cancer cells proliferation and sur- ...ERK signaling was not altered significantly whereas AKT sig- naling was obviously ...
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The Effect of 12 Weeks Aerobic Training on Expression of AKT1 and mTORc1 genes in the Left Ventricle of Type 2 Diabetic Rats
... the signaling pathways of PI3K / Akt and ...kinases Akt and ERK1 / 2 (kinase regulated extracellular signal 1/2) directly phosphorylate and inactivate the HSC TSC1 / 2 (stem cell sclerosis 1/2) ...
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Original Article shRNA-mediated silencing of PKHD1 gene promotes proliferation, migration and invasion of human intrahepatic cholangiocarcinoma HuCCT-1 cells
... tyrosine-mediated signaling play an important role in angiogenesis, invasion and migration of cholangiocarcinoma cells [36, ...downstream signaling pathways ...SH2-containing signaling mole- cules, ...
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Exploring the pathogenetic association between schizophrenia and type 2 diabetes mellitus diseases based on pathway analysis
... kinase, AKT is a key regulator of many signal transduction processes mediated by protein phosphorylation and a central molecule in regulating mul- tiple cellular processes such as glucose metabolism, tran- ...
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Identification of key gene pathways and coexpression networks of islets in human type 2 diabetes
... PI3K-Akt signaling pathway, citrate cycle (TCA cycle), TNF signaling pathway, central carbon metabolism in cancer, and glutathione metabolism (Figure ...cAMP signaling pathway, endocrine and ...
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