Aldehyde Dehydrogenase
Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro
... To confirm that the C. fritschii ALDH orthologue also appears to have been involved in lateral gene transfer from cyanobacteria to animals we undertook phylogenetic analysis. Sequences were chosen from [20] and [24], ...
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Computer Aided Modeling of Interaction between Aldehyde Dehydrogenase and Garcinia Biflavonoids
... [53] Sobreira, T.J., Marlétaz, F., Simões-Costa, M., Schechtman, D., Pereira, A.C., Brunet, F., Sweeney, S., Pani, A., Aronowicz, J., Lowe, C.J., Davidson, B., Laudet, V., Bronner, M., de Oliveira, P.S., Schubert, M., ...
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Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency
... In mammalian brain, g -aminobutyric acid (GABA) is quantitatively the most important inhibitory neuro- transmitter, and more than 30 per cent of neurones in the central nervous system (CNS) employ it to mediate ...
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Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross tolerance
... mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based ...
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In-silico identification of cis- acting regulatory elements in 5’ regulatory region of Betaine aldehyde dehydrogenase isoenzymes of selected monocot and dicot
... betaine aldehyde dehydrogenase is restricted tissue specific because of the occurrence of particular tissue cis-acting elements and may be modulated by various environmental stresses and hormone ...
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Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
... The ALDH1L2 gene encodes a protein that is 72.3 per cent identical with the ALDH1L1 and is also a fusion gene, comprising three domains: (a) the formyl-trans-N-formyl transferase (pfam00551) at the amino terminal ...
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Sjögren Larsson syndrome Deficient activity of the fatty aldehyde dehydrogenase component of fatty alcohol:NAD+ oxidoreductase in cultured fibroblasts
... Sjögren-Larsson syndrome (SLS) is an inherited disorder associated with impaired fatty alcohol oxidation due to deficient activity of fatty alcohol:NAD+ oxidoreductase (FAO). FAO is a complex enzyme which consists of two ...
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Prognostic values of aldehyde dehydrogenase 1 isoenzymes in ovarian cancer
... Abstract: Aldehyde dehydrogenase 1 (ALDH1) activity has been used as a functional stem cell marker to isolate cancer stem cells in different cancer types, including ovarian ...
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Aldehyde dehydrogenase 1 expression correlates with the invasion of breast cancer
... Breast cancer is a worldwide malignant disease. Recent studies [1–3] suggest that this disease is driven by a subpopulation of breast cancer cells, called breast tumor-initiating cells (BT-ICs), which have been identi- ...
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Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation
... Subpopulations of dopaminergic (DA) neurons within the substantia nigra pars compacta (SNpc) display a differential vulnerability to loss in Parkinson’s disease (PD); however, it is not clear why these subsets are pref- ...
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Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic plaque
... Previous studies demonstrated that aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which eliminates ALDH2 activity down to 1%-6%, is a susceptibility gene for coronary disease. Here we investigated the ...
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Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea
... Alcohol consumption is a serious health issue in Korea in terms of the amount consumed and the behavior related to its con- sumption. Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in alcohol metabolism ...
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The Aldehyde Dehydrogenase Gene Superfamily Resource Center
... The website www.aldh.org is a publicly available database for nomenclature and functional and molecular sequence information for members of the aldehyde dehydrogenase (ALDH) gene superfamily for animals, ...
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Update on the aldehyde dehydrogenase gene (ALDH) superfamily
... ALDH4A1 is missing from chimpanzee and common marmoset but is present in all others. Previously, rat ALDH4A1 had been conspicuously absent from the major databanks but it was recently added. During a BLAST search of the ...
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Laser light scattering and ultracentrifuge studies on sheep liver cytosolic aldehyde dehydrogenase : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Chemistry at Massey University, New Zealand
... l .2.3 Ultracentrifuge Studies on Aldehyde Dehydrogenase from Pseudomonas Aeruginosa Aldehyde dehydrogenase from pseudomonas aeruginosa has also been studied in the ultracentrifuge and t[r] ...
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Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring
... that aldehyde dehydrogenase family 1 (ALDH1) is upregulated in OMMP whole conjunctiva, in OMMP fibroblasts in vitro, and in the conjunctiva of an established mouse model of severe allergic eye disease (AED) ...
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Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung
... the aldehyde reductase activity was compared between these two mice, Aldh2 −/− mouse dis- played impaired Aldh activity only against acetaldehyde (as expected) and hexanal, while the Aldh2*2 Tg mouse showed ...
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The Role of Pesticide Induced Aldehyde Dehydrogenase Inhibition in the Pathogenesis of Parkinson’s Disease
... Discussion In this study, we examined the mechanisms by which rotenone inhibits proteasome activity and found that it likely involves multiple processes that appear to include mitochondr[r] ...
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Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites
... It is well-established that post-translational modification of proteins and enzyme can modulate the activity of many enzymes, thus playing an important role in cellular functions. Phosphorylation affects the activity of ...
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Mapping Aldehyde Dehydrogenase 1A1 activity using an [18F]Substrate based approach
... Given that fluorination proximal to the aldehyde moiety de- creased affinity for ALDH1A1, we next explored compounds with fluorine atoms that were remote from the aldehyde. Com- pounds 4 a and 4 b exhibited ...
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