Aldehyde Dehydrogenase 1
Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation
... of aldehyde dehydrogenase 1 ...to 1-methyl-4-phenylpyridinium–, glutamate-, or camptothecin-induced cell ...dopamine aldehyde interme- diates and formation of cytotoxic α-synuclein ...
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Prognostic values of aldehyde dehydrogenase 1 isoenzymes in ovarian cancer
... Abstract: Aldehyde dehydrogenase 1 (ALDH1) activity has been used as a functional stem cell marker to isolate cancer stem cells in different cancer types, including ovarian ...
8
Aldehyde dehydrogenase 1 expression correlates with the invasion of breast cancer
... Previous studies [1, 6-8] have found ALDH1 positive cancer cells may be associated with aggressive pheno- types and poor clinical outcomes in breast cancer pa- tients. Park and colleagues have attempted to ...
6
The role of aldehyde dehydrogenase-1 (ALDH1A1) polymorphisms in harmful alcohol consumption in a Finnish population
... the aldehyde dehydrogenase family focus on ALDH2, particu- larly in Asian populations, 25,26 recent studies 1,8,9 are shining light on the role that ALDH1A1 may play in several human alcohol-related ...
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Aldehyde dehydrogenase 1 expression in primary and metastatic renal cell carcinoma: an immunohistochemistry study
... grades 1 or 2 were compared to those with grades 3 or 4, whereas in the aforementioned study tumors with Fuhrman grades 1 or 2 were only compared to Fuhrman grade 4 tumors ...
9
Changes in aldehyde dehydrogenase 1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer
... One hundred and thirty four patients were recruited into the study between April 2004 and December 2011. Of these patients, two withdrew and a further nine were found to have computed tomography (CT) occult distant ...
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Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood–brain barrier model
... transporter 1; ABCG2: ATP- binging casette transporter family G transporter 2; AD: Alzheimer’s disease; ALDH1L1: aldehyde dehydrogenase 1 L1; ALS: amyotrophic lateral sclero- sis; ...
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Evaluation of Breast Cancer Stem Cells and Intratumor Stemness Heterogeneity in Triple-negative Breast Cancer as Prognostic Factors
... It has been recently suggested that breast cancer stem cells (BCSCs), which possess the capacity for self-renewal and differentiation, are responsible for tumor initiation, proliferation and progression [3]. The ...
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Original Article Expression of ALDH1, MACC1, and KAI1 in the triple-negative breast cancer and their clinical significance
... non-TNBC. Aldehyde dehydrogenase 1 (ALDH1, cancer stem cell biomarker), metastasis-associated in colon cancer-1 (MACC1), KAI1 (suppressor of cancer metastasis) are all useful predic- tive ...
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CD44 and CD24 cannot act as cancer stem cell markers in human lung adenocarcinoma cell line A549
... Despite the identification of a large number of risk factors involved in lung cancer, the incidence of the most common subtype of lung cancer, lung adenocarcinoma, is increasing, so the evaluation of critical aspects of ...
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Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer
... AURKA increases the enzymatic activity of ALDH1A1 Increased ALDH1A1 levels and activity are hallmarks of cancer stem cells. Thus, we investigated whether AURKA modulates the enzymatic activity of ALDH1A1. We designed a ...
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Evaluation of the correlation of vasculogenic mimicry, ALDH1, KiSS-1, and MACC1 in the prediction of metastasis and prognosis in ovarian carcinoma
... were excluded. All tissue samples (including both benign and malignant tumors) were obtained with patients’ con- sent. This study was approved by the ethics committee of Bengbu Medical College and performed in accordance ...
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Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro
... To confirm that the C. fritschii ALDH orthologue also appears to have been involved in lateral gene transfer from cyanobacteria to animals we undertook phylogenetic analysis. Sequences were chosen from [20] and [24], ...
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Action of Gaseous Nitric Oxide on Some Physical and Chemical Parameters of Human Blood Samples
... At present many scientists, including physiologists, doctors etc., pay their considerable attention to the investi- gation of the efficiency of nitric oxide use in different areas of biology and medicine [1]-[5]. ...
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Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor negative cancers in BRCA1 mutant mice
... A direct regulatory role of BRCA1 for the transcription of a receptor tyrosine kinase has been reported for the IGF- IR gene [20,21,39]. Abramovitch et al. [17] and Maor et al. [18] found that IGF-IR and IGF-IIR mRNA ...
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The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy
... E2 also mediates cardioprotection through GPR30 acti- vation on the mitochondrial surface. Bopassa et al. found that during I/R injury, GPR30 activation by E2 in adult male mice results in cardioprotection by inhibiting ...
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Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
... The authors’ current analysis of the ALDH genes within the human genome is now probably complete, and it can be concluded that the human ALDH gene superfamily comprises 19 genes in 11 families and four subfamilies ...
6
A Two DNA Methylation Signature to Improve Prognosis Prediction of Clear Cell Renal Cell Carcinoma
... The study was performed as indicated in Fig. 1. In total, 23171 DNA methylation sites were collected for 215 patient samples from the TCGA DNA methylation and clinical dataset. The me- dian age of the patients was ...
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Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy
... Numerous approaches are being used to study the effects of Notch signaling inhibition on many cancer types. These approaches include use of a neutralizing antibody against target proteins, use of dominant-negative mutant ...
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Alcohol consumption and breast tumor gene expression
... Gene expression microarray and quality control analysis RNA was extracted from multiple cores of 1 or 1.5 mm taken from tumor (N = 3 cores) or adjacent normal (N = 5 cores) tissues from FFPE blocks using the ...
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