Aldehyde Dehydrogenase 2
Aldehyde Dehydrogenase-2 Deficiency Aggravates Cardiac Dysfunction Elicited by Endoplasmic Reticulum Stress Induction
... Aldehyde dehydrogenase 2 (ALDH2) is emerging as a key enzyme of endoge- nous cytoprotection in the heart ...toxic aldehyde–induced reactive oxygen species formation ...cytotoxic ...
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Mitochondrial aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin
... Ever since its first clinical application in 1876, glyceryl trinitrate (GTN), also known as nitroglycerin, has been widely used for the management of coronary heart disease. Sublingual GTN admin- istration is the ...
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Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology
... Aldehyde dehydrogenase 2 deficiency (ALDH2*2) causes facial flushing in response to alcohol consumption in approximately 560 million East ...increased aldehyde levels in their brains ...
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Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea
... Alcohol consumption is a serious health issue in Korea in terms of the amount consumed and the behavior related to its con- sumption. Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in alcohol ...
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Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic plaque
... that aldehyde dehydrogenase 2 (ALDH2), as the key enzyme for classical alcohol metabolism, displays an important functional single-nucleotide polymorphism (SNP), or rs671-Glu504Lys polymorphism ...
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Inhibition of Aldehyde Dehydrogenase 2 by Oxidative Stress Is Associated with Cardiac Dysfunction in Diabetic Rats
... Left ventricular (LV) dysfunction is a common comorbidity in diabetic patients, although the molecular mechanisms underlying this cardiomyopathic feature are not completely understood. Aldehyde ...
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Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung
... To detect the overall effect of the ALDH2 polymorphism on lung function in the general population, we con- ducted a cross-sectional association study on healthy volunteers ( n = 967). Longitudinal data were also assessed ...
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Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment
... In this study, we investigated the level of ROS in the wild type mice and compared those from the ALDH2*2 mutant knock-in mice. Our data indicate that specific tissues may be impacted by cisplatin in different ...
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Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites
... The functional ALDH2 is a homotetramer [4]. In hu- man, a single point mutation in ALDH2 (E487K) greatly reduces the enzyme’s activity [5–7]. This over-dominant mutation, designated as ALDH2*2, is found in nearly ...
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Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese
... hyde dehydrogenase 2 (ALDH2) ...an aldehyde that is a lipid peroxidation prod- uct, such as 4-hydroxy-2-nonenal (4-HNE), and other alde- ...
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Original Article Simple and reliable genotyping of ALDH2 rs671 in the patients with acute alcoholism intoxication using Tetra-Primer ARMS PCR
... Aldehyde dehydrogenase-2 (ALDH2) is the sec- ond enzyme of the major oxidative pathway of alcohol metabolism, which plays a critical role by detoxifying exogenous and endogenous acetaldehydes into ...
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The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy
... ALDH2: Aldehyde dehydrogenase 2; AngII: Angiotensin II; Ap1: Activator protein-1; ArKO: Aromatase knockout; AROM+: Mice in which aromatase was transgenically upregulated; CAD: Coronary artery ...
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Interactive effects of a common γ-glutamyltransferase 1 variant and low high-density lipoprotein-cholesterol on diabetic macro- and micro-angiopathy
... ALDH2: Aldehyde dehydrogenase 2; ALT: Alanine aminotransferase; Apo: Apolipoprotein; ARB: Angiotensin II receptor blocker; AST: Aspartate aminotransferase; AUC: Area under the curve; B: Partial ...
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Effects of ADH1C, ALDH2, and CYP2A6 Polymorphisms on Individual Risk of Tobacco Related Lung Cancer in Male Japanese Smokers
... Vol. 2, ...alcohol dehydrogenase 1C (ADH1C) and aldehyde dehydrogenase 2 (ALDH2)] in 1039 male Japanese smokers (573 lung cancer patients and 466 healthy control subjects) who were ...
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Clinical significance of ALDH2 rs671 polymorphism in esophageal cancer: evidence from 31 case-control studies
... “aldehyde dehydrogenase-2”; “polymorphism”; and “esophagus”; “oesophagus”; and “carcinoma or cancer or neoplasm or tumour or ...risk; 2) the use of a case-control design; and 3) available ...
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Biosynthesis, regulation, and engineering of microbially produced branched biofuels
... essential 2-oxoacid dehydrogenase (OADH) and the pyruvate dehydro- genase (PDH), thus inhibiting cell growth and termi- nally branched LCFAs production ...
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Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro
... To confirm that the C. fritschii ALDH orthologue also appears to have been involved in lateral gene transfer from cyanobacteria to animals we undertook phylogenetic analysis. Sequences were chosen from [20] and [24], ...
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Analysis of biodegradation performance of furfural and 5-hydroxymethylfurfural by Amorphotheca resinae ZN1
... derivatives, 2-furaldehyde (furfural), furfuryl alcohol, 2-furoic acid (furoic acid), 5-hydroxymethylfurfural (HMF), 5-hydroxymethylfurfuryl alcohol (HMF alcohol), and 5-hydroxymethylfuroic acid (HMF acid) ...
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Action of Gaseous Nitric Oxide on Some Physical and Chemical Parameters of Human Blood Samples
... For complex estimation of erythrocytes energy metabolism we used two derivative coefficients, including lactate dehydrogenase activity in direct and reverse reactions and lactate level in these blood cells. It was ...
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Differential analysis of glioblastoma multiforme proteome by a 2D-DIGE approach
... In our study, we present five proteins that are also regulated in neurodegenerative diseases: UCHL-1, trans- htyretin, Apolipoprotein A1, DRP-2 and DRP-3. Altered expression of these proteins in Alzheimer ’ s ...
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