Aldehyde dehydrogenase (NAD+)
Sjögren Larsson syndrome Deficient activity of the fatty aldehyde dehydrogenase component of fatty alcohol:NAD+ oxidoreductase in cultured fibroblasts
... Sjögren-Larsson syndrome (SLS) is an inherited disorder associated with impaired fatty alcohol oxidation due to deficient activity of fatty alcohol:NAD+ oxidoreductase (FAO). FAO is a complex enzyme which consists of two ...
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Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro
... To confirm that the C. fritschii ALDH orthologue also appears to have been involved in lateral gene transfer from cyanobacteria to animals we undertook phylogenetic analysis. Sequences were chosen from [20] and [24], ...
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Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency
... semialdehyde dehydrogenase (SSADH; aldehyde dehydrogenase 5A1 [ALDH5A1]; locus 6p22) occupies a central position in central nervous system (CNS) neurotransmitter metabolism as one of two enzymes ...
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Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic plaque
... that aldehyde dehydrogenase 2 (ALDH2), as the key enzyme for classical alcohol metabolism, displays an important functional single-nucleotide polymorphism (SNP), or rs671-Glu504Lys polymorphism ...
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Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross tolerance
... GTN metabolism and biotransformation have been proposed. The list of candidate enzymes includes glu- tathione S-transferases (1), the cytochrome p450 sys- tem (2), xanthine oxidoreductase (3), and mitochondr- ial ...
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In-silico identification of cis- acting regulatory elements in 5’ regulatory region of Betaine aldehyde dehydrogenase isoenzymes of selected monocot and dicot
... betaine aldehyde dehydrogenase is restricted tissue specific because of the occurrence of particular tissue cis-acting elements and may be modulated by various environmental stresses and hormone ...
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Computer Aided Modeling of Interaction between Aldehyde Dehydrogenase and Garcinia Biflavonoids
... [6] Yao, L., Fan, P., Arolfo, M., Jiang, Z., Olive, M.F., Zablocki, J., Sun, H.L., Chu, N., Lee, J.J., Kim, H.Y., Leung, K., Shryock, J., Blackburn, B., Diamond, I. 2010. Inhibition of aldehyde ...
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Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
... The ALDH1L2 gene encodes a protein that is 72.3 per cent identical with the ALDH1L1 and is also a fusion gene, comprising three domains: (a) the formyl-trans-N-formyl transferase (pfam00551) at the amino terminal ...
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Prognostic values of aldehyde dehydrogenase 1 isoenzymes in ovarian cancer
... Abstract: Aldehyde dehydrogenase 1 (ALDH1) activity has been used as a functional stem cell marker to isolate cancer stem cells in different cancer types, including ovarian ...
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Aldehyde dehydrogenase 1 expression correlates with the invasion of breast cancer
... Breast cancer is a worldwide malignant disease. Recent studies [1–3] suggest that this disease is driven by a subpopulation of breast cancer cells, called breast tumor-initiating cells (BT-ICs), which have been identi- ...
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Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation
... Subpopulations of dopaminergic (DA) neurons within the substantia nigra pars compacta (SNpc) display a differential vulnerability to loss in Parkinson’s disease (PD); however, it is not clear why these subsets are pref- ...
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Update on the aldehyde dehydrogenase gene (ALDH) superfamily
... Table 2 summarises these ALDH orthologues, their chromosomal locations and the associated NCBI Entrez gene identification (ID) number for each of the 11 species. For zebrafish, Entrez gene ID 100334142 was listed as ...
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Laser light scattering and ultracentrifuge studies on sheep liver cytosolic aldehyde dehydrogenase : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Chemistry at Massey University, New Zealand
... l .2.3 Ultracentrifuge Studies on Aldehyde Dehydrogenase from Pseudomonas Aeruginosa Aldehyde dehydrogenase from pseudomonas aeruginosa has also been studied in the ultracentrifuge and t[r] ...
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Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring
... that aldehyde dehydrogenase family 1 (ALDH1) is upregulated in OMMP whole conjunctiva, in OMMP fibroblasts in vitro, and in the conjunctiva of an established mouse model of severe allergic eye disease (AED) ...
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The Aldehyde Dehydrogenase Gene Superfamily Resource Center
... The website www.aldh.org is a publicly available database for nomenclature and functional and molecular sequence information for members of the aldehyde dehydrogenase (ALDH) gene superfamily for animals, ...
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Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea
... Alcohol consumption is a serious health issue in Korea in terms of the amount consumed and the behavior related to its con- sumption. Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in alcohol metabolism ...
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The Role of Pesticide Induced Aldehyde Dehydrogenase Inhibition in the Pathogenesis of Parkinson’s Disease
... Discussion In this study, we examined the mechanisms by which rotenone inhibits proteasome activity and found that it likely involves multiple processes that appear to include mitochondr[r] ...
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Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung
... the aldehyde reductase activity was compared between these two mice, Aldh2 −/− mouse dis- played impaired Aldh activity only against acetaldehyde (as expected) and hexanal, while the Aldh2*2 Tg mouse showed ...
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Mapping Aldehyde Dehydrogenase 1A1 activity using an [18F]Substrate based approach
... Given that fluorination proximal to the aldehyde moiety de- creased affinity for ALDH1A1, we next explored compounds with fluorine atoms that were remote from the aldehyde. Com- pounds 4 a and 4 b exhibited ...
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Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites
... It is well-established that post-translational modification of proteins and enzyme can modulate the activity of many enzymes, thus playing an important role in cellular functions. Phosphorylation affects the activity of ...
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