Aldo-keto reductase
Regulation of Aldo-keto-reductase family 1 B10 by 14-3-3ε and their prognostic impact of hepatocellular carcinoma
... 14-3-3ε is overexpressed in hepatocellular carcinoma (HCC) and its expression significantly associates with a poor prognostic outcome. To uncover how 14-3-3ε contributes to the tumor progression of HCC, we investigated ...
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Original Article Aldo-keto reductase family 1 member B8 is secreted via non-classical pathway
... Mouse aldo-keto reductase family 1 member B8 (AKR1B8) has the highest similarity to human aldo- keto reductase family 1 member B10 (AKR1B10), a secretory protein through ...
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Quality of life effects of androgen deprivation therapy in a prostate cancer cohort in New Zealand: can we minimize effects using a stratification based on the aldo-keto reductase family 1, member C3 rs12529 gene polymorphism?
... Methods: A cohort of 206 PC survivors (75 treated with and 131 without ADT) was recruited with written consent to collect patient characteristics, clinical data and HRQoL data related to PC management. The primary ...
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Aldo-keto Reductase Family 1 Member C3 (AKR1C3) Is a Biomarker and Therapeutic Target for Castration-Resistant Prostate Cancer
... (CRPC). Aldo-keto reductase family 1 member C3 (AKR1C3) is a steroidogenic enzyme that plays a crucial role in the conversion of adrenal androgen dehydroepiandrosterone (DHEA) into high-affinity ...
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Low expression of Aldo–keto reductase 1B10 is a novel independent prognostic indicator for nasopharyngeal carcinoma
... Aldo-keto reductase family 1 member B10 (AKR1B10), also called as aldose reductase like protein-1 (ARL-1), belongs to the aldehyde ketone reductase (AKRs) fam- ily ...
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Silencing of aldo keto reductase 1C3 by siRNA increases chemosensitivity of prostate cancer cells
... Aldo-keto reductase 1C3 (AKR1C3) is a member of the aldo-keto reductase protein superfamily [6]. It plays a pivotal role in androgen biosynthesis and in the pre-receptor ...
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Human aldo keto reductase 7A3 protects LO2 cells against APAP induced oxidative stress and cell death
... the aldo-keto-reductase family which exhibits broad substrate specificity for a variety of reactive aldehydes such as aflatoxin, acrolein, and methylglyoxal (Barski et ...
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Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats
... Euthanasia was performed by decapitation under light etherization. Aldo-keto reductase activity was measured in blood serum [21]. For this purpose, 0.1 ml of blood serum was added to a ...
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Expression Analysis of Aldo Keto Reductase 1 (AKR1) in Foxtail Millet (Setaria italica L ) Subjected to Abiotic Stresses
... that aldo-keto reductase genes (AKRs) are stress regulated genes and play a central role in the cellular response to osmotic and oxidative stresses by detoxifying toxic aldehydes generated during ...
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The Coptotermes gestroi aldo–keto reductase: a multipurpose enzyme for biorefinery applications
... Background: In nature, termites can be considered as a model biological system for biofuel research based on their remarkable efficiency for lignocellulosic biomass conversion. Redox enzymes are of interest in ...
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Aldehyde reductase activity and blood aldo-keto reductase spectrum in adolescents with neuroendocrine obesity
... blood aldo-keto reductase spectrum has been performed in 13-15 and 16-18-years old adoles- cents with obesity to clear up the mechanisms of neuroendocrine obesity at the age of ...aldehyde ...
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Original Article Expression of aldo-keto reductase family 1 member C3 (AKR1C3) in neuroendocrine tumors & adenocarcinomas of pancreas, gastrointestinal tract, and lung
... Human aldo-keto reductase family 1 member C3 (AKR1C3) was initially identified as an enzyme in reduc- ing 5α-dihydrotestosterone (5α-DHT) to 5α-androstane-3α, 17β-diol (3α-diol) and oxidizing 3α-diol ...
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Original Article Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell car- cinoma but not small cell carcinoma
... Human aldo-keto reductase family 1 member C3 (AKR1C3) was initially identified as a critical enzyme in reducing 5α-dihydrotestosterone (5α-DHT) to 5α-androstane-3α,17β-diol (3α-diol) and oxidizing ...
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The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner
... AKR7A2 is a member of the aldo/keto reductase (AKR) superfamily and AKR7 family. AKRs are a superfamily of NADP(H)-dependent enzymes that reduce aldehydes and ketones to alcohols [10]. Several AKR ...
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Aldo-keto reductase (AKR) superfamily: Genomics and annotation
... Aldo-keto reductases (AKRs) are phase I metabolising enzymes that catalyse the reduced nicotinamide adenine dinucleotide ( phosphate) (NAD(P)H)-dependent reduction of carbonyl groups to yield primary and ...
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DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome
... AKR1C3, aldo-keto reductase family 1 member C3; AR, androgen receptor; CASR, calcium-sensing receptor; COC, cumulus-oophorus complex; FF, follicular fluid; FSH, follicle-stimulating hormone; FSHR, ...
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Gene mining-based identification of aldo–keto reductases for highly stereoselective reduction of bulky ketones
... 2017). Aldo–keto reductase (AKR) or alcohol dehy- drogenase (ADH)-mediated stereoselective reduc- tion of prochiral carbonyl compounds is an efficient way of preparing single enantiomers of chiral ...
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Prevalence of Salmonella enterica in Poultry and Eggs in Uruguay during an Epidemic Due to Salmonella enterica Serovar Enteritidis
... Predicted function/annotation Sulfatases, secreted proteins Putative aldo/keto reductase Putative LysR family transcriptional regulator Putative viral enhancing factor Part of SPI-6, Rsh[r] ...
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Characterization of erythrose reductase from Yarrowia lipolytica and its influence on erythritol synthesis
... erythrose reductase [4], which catalyzes the final step in this ...erythrose reductase from ...the aldo–keto reductase (AKR) superfamily and compared them with other erythrose ...
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Effects of Hyperoxia and Hypoxia on Vascular Prostacyclin Formation in Vitro
... Production of endogenous radioimmunoassayable 6-keto-prostaglandin F1,, (6- keto-PGF,a) in picomoles per milligram of vascular tissue) following short-term in vitro exposure of paired hu[r] ...
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