alkylating agent
Proteomic analysis of mismatch repair-mediated alkylating agent-induced DNA damage response
... Cell cycle progression in MNNG-treated TK6 and MT1 cells The goal of this study was to analyze MNNG-induced changes in the proteome and phosphoproteome of the MMR-proficient TK6 cell line and its MSH6-deficient ...
14
Novobiocin enhances alkylating agent cytotoxicity and DNA interstrand crosslinks in a murine model
... modulating agent of cytotoxicity due to DNA-DNA crosslinking, novobiocin may enhance the clinical effectiveness of the alkylating agents in human cancer and offer insight into new therapeutic ...
6
Spectroscopic (ft ir, ft raman and uv vis) study, homo lumo, nbo and molecular docking analysis of alkylating agent: bis chloroethylnitrosourea
... Electrostatic potential (ESP) useful quantities to illustrate the charge distributions of molecules are used to visualize variably charged regions of a molecule. Therefore the charge distribution can give the information ...
18
Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard.
... Based on the decrease in the G2 population and the reduction in the hyperphosphorylated form of cdc2 kinase in Vpr-arrested cells treated with pentoxifylline or caffeine, we conclude tha[r] ...
11
INDUCTION OF DOMINANT LETHAL MUTATIONS IN INSECT OOCYTES AND SPERM BY GAMMA RAYS AND AN ALKYLATING AGENT: DOSE-RESPONSE AND JOINT ACTION STUDIES
... In undertaking the studies reported herein we had several immedi- ate objectives: ( 1 ) T o determine dose-response curves for induction of dominant lethal mutations by eithe[r] ...
10
Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent
... First, to replicate the covalent modification observed in the MS/MS experiments with S3I-201, we incubated purified STAT3 protein with 100 μM of 4a the approximate IC50 for the disruptio[r] ...
11
COMPARATIVE MUTAGENESIS OF THE DUMPY LOCUS IN DROSOPHILA MELANOGASTER. II. MUTATIONAL MOSAICISM INDUCED WITHOUT APPARENT BREAKAGE BY A MONOFUNCTIONAL ALKYLATING AGENT
... Moreover, as was pointed out in the analysis of the X-irradiated dumpy region ( CARLSON and SOUTHIN 1962) , calculations indicated that the true incidence of gene mutation, com[r] ...
16
Topanol A as an Antioxidant for Jet Fuel: Preparation and Application
... an alkylating agent in the presence of a catalyst. The alkylating agents are typically alcohols or olefins, and some of the corresponding catalysts include Lewis acid catalysts, inorganic and/or ...
7
ESCHERICHIA COLI GENE INDUCTION BY ALKYLATION TREATMENT
... These nine strains contained fusions that were specifically induced by an alkylating agent and, therefore, met our criteria for alkylation-inducible ( a i d ) genes. T[r] ...
16
1678.pdf
... In 2007, Jha et al. published the results of a similar RCT comparing cyclophosphamide and steroids to conservative therapy. 6 Their study was slightly larger (n=93), and also followed patients for 10 years. They compared ...
45
Studies on novel human DNA damage sensitive cell lines
... and alkylating agents, as to what might be defective in this cell ...of alkylating agent and ionizing radiation cross sensitivity seen in the fibroblast cell line 46BR ...
186
Synthesis and biological evaluation of novel anthraquinones with alkylating capability
... lead agent ZP281M, a compound active against MDR and alkylating agent resistant cells in vitro [33, 143] and in vivo [137], and (2) the further opportunity to develop di-A-oxides of ...
205
Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase
... DNA alkylating agent methyl methanesulfonate, which induces replication blocks and extensive formation of chromosomal linkages due to template switching mechanisms required for fork ...
19
PubMedCentral-PMC5060005.pdf
... catalytic amount of KI. The target compounds were prepared by first N-alkylating potassium phthalimide with 1,4-dibromobutane to produce alkyl bromide 1b which was separately reacted with THIQ, ...
23
Studies of alkylcobaloximes as models for a B12 dependent rearrangement
... suitable alkylating agent and a pentacoordinate cobalt species, but has to be isolated and characterised as well, before proper studies on it can ...
186
Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus
... Aspergillus fumigatus (A. fumigatus) is responsible for a range of devastating diseases in immunocompromised individuals, and while the extent of disease depends largely on the immune status of the host, mortality rates ...
16
Survey on Key Technologies in Cloud Workflow System Integration
... Similar to many other workflow systems, scheduling is a very important component in cloud work- flow systems. It directly determines the performance of the whole system. The workflow engine based on MAS is built on the ...
7
Multi-Agent Based Pervasive Health Care Monitoring System
... view, Agent informs the messages about the patient Health proactively, which reduces cost, it saves the ...this agent can tell the complexity about the patient health to both the people and the ...
5
An Improved Contract Net Protocol with Multi Agent for Reservoir Flood Control Dispatch
... cooperated Agent receives the bid parameter of reservoir dispatcher Agent, because there are the differ- ent dimension parameters for the lowest water level and the lowest water temperature in the water ...
12
Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs
... In a next step we targeted MEK with two specific inhib- itors, U0126 and PD98059, respectively. Cell lines U373 and U251 have been reported to be both NF1-deficient and to display different sensitivities for MEK ...
14