alkylating agents
Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus
... to alkylating agents exists in the widespread and highly pathogenic fungus ...to alkylating agents, and that deletion of the genes encoding the AGT and the MPT ablates this response in the ...
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Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents
... SDH-deficient GISTs feature pervasive DNA methy- lation, which appears, nevertheless, to be not randomly distributed, as evidenced by the significant number of recurrent hypo- and hypermethylated genomic targets found in ...
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Alkylating agents and immunotoxins exert synergistic cytotoxic activity against ovarian cancer cells Mechanism of action
... When alkylating agents and toxin conjugates were used in combination, the addition of the immunotoxins to cisplatin, or to cisplatin and thiotepa, produced synergistic cytotoxic activity against the OVCA ...
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MUTAGENESIS BY CYTOSTATIC ALKYLATING AGENTS IN YEAST STRAINS OF DIFFERING REPAIR CAPACITIES
... The ability of haploid stationary-phase cells of yeast to survive treatment by alkylating agents of different functionality i s clearly dependent on the integrity of several genes[r] ...
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A COMPARISON OF THE TERATOGENIC EFFECTS OF FIVE POLYFUNCTIONAL ALKYLATING AGENTS ON THE RAT FETUS
... Fic. Ratio of dosage of alkylating agents and x-rays given pregnant rats on the twelfth day of gesta- tion to produce various effects on mother and fetus to estimated litter LDo.. Litter[r] ...
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Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death
... decreasing the dose required, which in turn can reduce the side effects associated with MMC, DDP, and CTX. GLB sensitizes GC cells by interfering with proliferation, arresting the cell cycle, impairing replication, ...
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DIFFERENTIAL SENSITIVITY OF MOUSE SPERMATOGENESIS TO ALKYLATING AGENTS
... Chromosome breaks estimated by anaphase fragments are plotted in Figure 1 A, which shows that (1) the sensitivity of various stages is different for the three compounds; and [r] ...
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Alkylating agents induce UVM, a recA-independent inducible mutagenic phenomenon in Escherichia coli.
... In addition, strain-testrain variability in transfection efficiency is also observed, as reflected in the data on strains defective for alkylation repair ($ a m and a W [r] ...
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DNA REPAIR DEPENDENCE OF SOMATIC MUTAGENESIS OF TRANSPOSON-CAUSED WHITE ALLELES IN DROSOPHILA MELANOGASTER AFTER TREATMENT WITH ALKYLATING AGENTS
... Comparison of somatic reversions between the ivory allele and transposon-caused mutant alleles a t the white locus of Drosophila melanogaster after larval treatment with[r] ...
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Linear Growth of Children With Nephrotic Syndrome: Effect of Alkylating Agents
... sessed in 12 children with steroid responsive but frequent relapsing or dependent nephrotic syndrome prior to and following treatment with either cyclophosphamide or chlorambucil and alt[r] ...
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INDUCTION OF MITOTIC CROSSING-OVER IN ASPERGILLUS NIDULANS BY BIFUNCTIONAL ALKYLATING AGENTS
... At doses which give approximately the same mutagenic effect the two-armed compounds produce a strong increase in the crossing-over frequency while the one-armed compounds are almo[r] ...
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Serum AMH level as a marker of acute and long-term effects of chemotherapy on the ovarian follicular content: a systematic review
... including alkylating agents, are notori- ously ovariotoxic by damaging all kinds of follicles from primary to preantral and antral stages ...including alkylating agents, leading to premature ...
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1678.pdf
... were alkylating agents (chlorambucil and cyclophosphamide), calcineurin inhibitors (cyclosporine and tacrolimus), and steroids ...the alkylating agent or calcineurin inhibitor group if they received ...
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Alkylating chemotherapeutic agents cyclophosphamide and melphalan cause functional injury to human bone marrow derived mesenchymal stem cells
... of alkylating agents known as nitrogen mustard ...chemotherapeutic agents by the formation of DNA alkyl adducts and inter-strand DNA-cross links, inducing cellular apoptosis ...these agents ...
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Topanol A as an Antioxidant for Jet Fuel: Preparation and Application
... an alkylating agent in the presence of a catalyst. The alkylating agents are typically alcohols or olefins, and some of the corresponding catalysts include Lewis acid catalysts, inorganic and/or ...
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GENETIC EFFECTS OF ETHYL METHANESULFONATE IN COMBINATION WITH COPPER AND ZINC IONS ON ARABIDOPSIS THALIANA
... Metallic ions like calcium and magnesium are essential for the integrity of the chromosomes (STEFFENSEN and BERGERON 1959) and alkylating agents used in combination with[r] ...
5
Charlotte Auerbach (1899-1994).
... Even this delay had its advantages, because LOTTE was able to conduct an unhurried and careful comparison of the genetic effects of alkylating agents and ionizing r[r] ...
5
Influence of dna repair on nonlinear dose responses for mutation
... DNA-reactive alkylating agents exhibit a linear ...model alkylating agents methyl- and ethylmethanesulfonate and methylnitrosourea (MNU) and ethylnitrosourea observe a nonlinear dose-response ...
9
Studies of alkylcobaloximes as models for a B12 dependent rearrangement
... R. H. Schlessinger et al. have studied the deconjugative alkylation of ethyl crotonate using various alkylating agents; LDA/HMPA in THF at -78° was employed as base. During the present work it was hoped ...
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Studies on novel human DNA damage sensitive cell lines
... Engel ward et a l, 1997). Phenotypically the mice are viable, grow appropriately and are fertile. Mouse embryonic fibroblasts (MEF) show sensitivity to alkylating agents. Ionizing radiation sensitivity ...
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