All-trans retinoic
All trans retinoic acid modulates the retinoic acid receptor alpha in promyelocytic cells
... that all-trans retinoic acid (RA), the active metabolite of vitamin A, is an efficient alternative to chemotherapy in the treatment of acute promyelocytic leukemia ...the retinoic acid ...
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THE EFFECT OF ALL-TRANS RETINOIC ACID AND FATTY ACIDS ON MCF-7 BREAST CANCER CELL PROGRESSION
... Vitamin A metabolites and retinoids may slow the progression of breast cancer and elicit anti-neoplastic properties similar to those of omega-3 fatty acids. Studies using animal models show a decrease in the incidence, ...
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A Gene(s) for All-trans-Retinoic Acid-Induced Forelimb Defects Mapped and Confirmed to Murine Chromosome 11
... ectrodac- all-trans-retinoic acid (RA) has caused congenital mal- tyly was demonstrated for other teratogens, including formations that varied in scope and severity with dose acetazolamide, cadmium, ...
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Rp-Hplc Method Development and Validation for the Estimation of All-Trans Retinoic Acid in Plant Extract of Broccoli and Spinach.
... influenced by the presence (i.e., additional absorption) of another substance. Peak purity was assessed by using LC Solution software for the HPLC/PDA system based on the degree of similarity of UV spectra across the ...
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The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia
... even been tried as prolonged consolidation therapy in older people [45]. Finally, an unplanned final analysis of a randomized clinical trial showed that decitabine caused a significantly increased complete remission ...
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Arsenic trioxide and all trans retinoic acid (ATRA) treatment for acute promyelocytic leukemia in all risk groups: study protocol for a randomized controlled trial
... Background: The treatment of acute promyelocytic leukemia (APL) has been revolutionized in the past two decades by the advent of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). It suggests ...
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Granulocyte colony-stimulating factor potentiates all-trans retinoic acid-induced granulocytic differentiation in acute promyelocytic leukemia cell line HT93A
... Granulocyte colony-stimulating factor (G-CSF) is a myeloid growth factor that promotes proliferation, survival, and differentiation of myeloid-lineage leukemic cells, as well as normal hematopoietic cells [1,2]. Clinical ...
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Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
... that all-trans retinoic acid (ATRA)--a therapy for acute promyelocytic leukemia (APL) that is considered the first example of targeted therapy in cancer, but its drug target remains elusive--inhibits ...
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Potential for combined delivery of riboflavin and all trans retinoic acid, from silk fibroin for corneal bioengineering
... Millions of people worldwide su ff er from vision impairing conditions resulting from corneal injury or disease. Silk fibroin (SF) is an emerging biopolymer that has been used for several applications including the ...
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All trans retinoic acid stimulates synthesis of cyclic ADP ribose in renal LLC PK1 cells
... Cyclic adenosine diphospho-ribose (cADPR) triggers Ca2+ release from intracellular stores and is therefore proposed to function as a second messenger in cellular signaling; however, an extracellular stimulus, i.e., first ...
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All trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy
... not all patients derive therapeutic benefit and some breast cancers are resistant to the treatment, and are thus evidenced with prospective distant metastatic spread and local ...of all-trans ...
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Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patients
... All-trans retinoic acid (RA) plays key roles in cancer treat- ment and prevention. Breast, lung, bladder, prostate, and acute promyelocytic leukemia (APL) cancers were shown to be suppressed by RA ...
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CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid
... Glioblastomas respond differently to all-trans retinoic acid (RA) for unknown reasons. Because CRABP-II and FABP5 mediate RA intracellular signaling respectively and lead to distinct biological ...
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Selenite promotes all- trans retinoic acid-induced maturation of acute promyelocytic leukemia cells
... with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) have dramatically improved the survival of APL patients with higher percentage of complete remission ...
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All Trans Retinoic Acid Has a Potential Therapeutic Role for Diabetic Nephropathy
... nificant difference in weights among the three groups prior to 28 weeks. After 28 weeks of age, the OLETF rats weighed more than the LETO rats of the same age, while there was no statistical difference in weights be- ...
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Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid
... Abstract: This study was aimed to develop a novel microemulsion that contained oleth-5 as a surfactant to enhance the oral absorption of all-trans retinoic acid (ATRA). The prepared microemulsion was ...
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Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid
... and all-trans retinoic acid (ATRA), our strategy was to entrap GA in the self-assembled nanopar- ticles based on amphiphilic hyaluronic acid (HA)-ATRA (HRA) ...
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A fourth subtype of retinoic acid receptor-related orphan receptors is activated by oxidized all-trans retinoic acid in medaka (Oryzias latipes)
... A Gal4-regulated reporter vector which contains the luciferase gene under the control of five GAL4 binding sites upstream of a minimal TATA box, named pG5luc, was from the CheckMate mammalian two-hybrid system (Promega). ...
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All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype
... All samples at the end of the 28 days of treatment were harvested and washed in PBS twice while maintained in ice. Cell pellets were lysed by the addition of 0.5 ml of TRIzol reagent (Invitrogen). RNA was ...
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Effect of all-trans retinoic acid on the proliferation and differentiation of brain tumor stem cells
... to all, EGF and bFGF, as powerful promo- ters of cell division, are essential key components in stem cell culture medium, and enable stem cells to proliferate ...
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