Alpha-2 adrenergic receptor
![Variations in circulating catecholamines fail to alter human platelet alpha 2 adrenergic receptor number or affinity for [3H]yohimbine or [3H]dihydroergocryptine](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
Variations in circulating catecholamines fail to alter human platelet alpha 2 adrenergic receptor number or affinity for [3H]yohimbine or [3H]dihydroergocryptine
... platelet alpha-2 binding site number and the affinity (KD) of these sites for antagonist ...study, alpha-2-adrenergic binding site number and affinity were compared using ...
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Characterization and distribution of alpha 2 adrenergic receptors in the human intestinal mucosa
... the alpha 2-adrenergic receptor were investigated in the normal mucosa from human intestine by means of radioligand binding, RNase mapping, and measurement of adenylate cyclase ...the ...
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Functional characterization of the alpha adrenergic receptor modulating the hydroosmotic effect of vasopressin on the rabbit cortical collecting tubule
... an alpha adrenergic agonist, resulted in a significant decrease in Jv and Pf to ...an alpha adrenergic antagonist, did not cause any significant change in Jv and Pf, which were ...an ...
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Confirmation of subtype of Alpha-1 adrenergic receptor producing relaxation in goat artery strip
... mentioned, alpha adrenergic receptor is divided into alpha 1 and ...The alpha 1 receptor is further subdivided into alpha - 1A, 1B and ...of alpha 1 ...
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Responsiveness of superficial hand veins to phenylephrine in essential hypertension Alpha adrenergic blockade during prazosin therapy
... endogenous alpha adrenergic ...an alpha 1 adrenergic receptor agonist, and to nitroglycerin, a venorelaxant, in patients with essential hypertension and in normotensive ...
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Myocardial beta adrenergic receptor function during the development of pacing induced heart failure
... beta-adrenergic receptor density was not changed at any time point, but beta 1-adrenergic receptor density was decreased (P < ...Gi alpha 2 isoform of the alpha subunit ...
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Glucocorticoids induce transcription and expression of the alpha 1B adrenergic receptor gene in DTT1 MF 2 smooth muscle cells
... of alpha 1 adrenergic receptors, which could contribute to the increased sensitivity of vascular smooth muscle to catecholamines that may occur with glucocorticoid ...the alpha 1B adrenergic ...
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Reduced beta adrenergic receptor activation decreases G protein expression and beta adrenergic receptor kinase activity in porcine heart
... Gi alpha 2 and Gs alpha mRNA and protein expression in the left ventricle; reduced G-protein content was also found in the right ...beta-adrenergic receptor-dependent stimulation of ...
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The hepatic action of alpha-adrenergic agonists
... Phenylephrine (2.0/iM) induces an a r receptor-mediated net efflux of Ca2+ from livers of fed rats perfused with medium containing physiological concentrations (1.3 mM) of Ca2+. The onset of efflux (7.1±0.5s; n — ...
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Enhanced inositol trisphosphate response to alpha 1 adrenergic stimulation in cardiac myocytes exposed to hypoxia
... increases alpha 1-adrenergic receptor density, also leads to an enhanced production of inositol trisphosphate and could account for the enhanced alpha 1-adrenergic responsivity in the ...
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Anti–β1 adrenergic receptor antibodies and heart failure: causation, not just correlation
... There currently exist a great number of different mouse lines in which the activity of a particular gene of interest has been inactivated or enhanced. However, it is also possible to insert specific mutations in a gene ...
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Paroxysmal hypnogenic dyskinesia is associated with mutations in the PRRT2 gene
... (A) The pedigree (left) and PRRT2 sequence (right) of the patient with mutation of c.649dupC (patient 1). The patient carried the heterozygous mutation of the PRRT2 gene c.649dupC (p.Arg217ProfsX8), inherited from his ...
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Asthma pharmacogenetics and the development of genetic profiles for personalized medicine
... Glucocorticoids target a biologic pathway consisting of biosynthetic hormones that bind and activate a cytosolic chaperone-receptor heterocomplex in the cytosol which translocates into the nucleus to repress the ...
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Conversion of epidermal growth factor receptor 2 and hormone receptor expression in breast cancer metastases to the brain
... the receptor phenotype of brain metas- tases does not reflect its status in primary ...of receptor gain, may deny some patients a poten- tially effective systemic ...
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Phosducin influences sympathetic activity and prevents stress induced hypertension in humans and mice
... in blood pressure in response to post-operative stress. Candidate gene–based association studies in 2 differ- ent human populations revealed several SNPs in the PDC gene to be associated with stress-dependent ...
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[beta]2-adrenergic receptor modulation of macrophage inflammatory mediator production
... transcriptional regulation of several pro-inflammatory molecules, the mechanisms surrounding TNF-α production are the most studied. In 2000, Farmer and Pugin published a landmark paper describing the molecular basis of ...
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Original Article Relationship between the β1-adrenergic receptor and the β2-adrenergic receptor in hypertension
... β adrenergic receptors (β-ARs) are involved in the pathogenesis of hypertension, which is a major risk factor for cardiovascular diseases, including coronary artery disease, heart failure, chronic kidney disease, ...
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Beta adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms
... myocardial adrenergic receptors, adrenergic neurotransmitters, and beta-adrenergic receptor-effector responses in nonfailing and failing hearts taken from nonfailing organ donors, subjects ...
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Science review: Mechanisms of beta receptor stimulation induced improvement of acute lung injury and pulmonary edema
... Acute lung injury (ALI) and the acute respiratory distress syndrome are complex syndromes because both inflammatory and coagulation cascades cause lung injury. Transport of salt and water, repair and remodeling of the ...
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Interaction of β1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling
... physically interacted with each other in HEK293 cells expressing HA-tagged β1AR and Flag-tagged RAGE, suggesting β1AR and RAGE may form a protein complex in intact cells (Figure 7A). Indeed, time-resolved fluorescence ...
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