alpha/beta interferon receptor
The Alpha/Beta Interferon Receptor Provides Protection against Influenza Virus Replication but Is Dispensable for Inflammatory Response Signaling
... inducing interferon production. By engaging interferon receptors, interferon activates the JAK-STAT pathway and results in the positive feedback of interferon production, amplifying the ...
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Establishment of a Poliovirus Oral Infection System in Human Poliovirus Receptor-Expressing Transgenic Mice That Are Deficient in Alpha/Beta Interferon Receptor
... Poliomyelitis is an acute disease of the central nervous sys- tem (CNS) caused by poliovirus (PV), a human enterovirus that belongs to the family Picornaviridae. In humans, an infec- tion is initiated by oral ingestion ...
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Promotion of Alpha/Beta Interferon Induction during In Vivo Viral Infection through Alpha/Beta Interferon Receptor/STAT1 System-Dependent and -Independent Pathways
... of alpha/beta interferons (IFN- ␣ /  ...through interferon regulatory factor 7 (IRF-7) ... receptor-deficient (IFN- ␣ /  R ⴚ/ⴚ ) and STAT1 ⴚ/ⴚ mice compared to those in wild-type ...
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Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice.
... So far, studies of protective effector mechanisms against VSV have been performed in normal or immunodeficient mice, in which the virus usually replicates productively only in the central nervous system and cannot be ...
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The Pathogenesis of Severe Fever with Thrombocytopenia Syndrome Virus Infection in Alpha/Beta Interferon Knockout Mice: Insights into the Pathologic Mechanisms of a New Viral Hemorrhagic Fever
... However, alpha/beta interferon receptor knockout (IFNAR ⴚ/ⴚ ) mice were highly susceptible to SFTSV infection, and all mice died within 3 to 4 days after subcutaneous inoc- ulation of 10 6 ...
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Immune Response to Mouse Mammary Tumor Virus in Mice Lacking the Alpha/Beta Interferon or the Gamma Interferon Receptor
... The overall efficiency of MMTV infection is critically depen- dent upon the interaction between the virus and the immune system (17, 20). In addition to the usual retroviral genes gag, pol and env, the viral genome ...
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“Self” and “Nonself” Manipulation of Interferon Defense during Persistent Infection: Bovine Viral Diarrhea Virus Resists Alpha/Beta Interferon without Blocking Antiviral Activity against Unrelated Viruses Replicating in Its Host Cells
... IFN receptor was possible despite the complete block of synthesis of bioactive IFN in response to dsRNA, thus indicat- ing a complete separation of IFN induction from IFN action in these ...
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Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon
... genes. Alpha/beta IFNs (IFN-␣/), represented by several IFN-␣ subtypes, IFN-, and IFN-, bind to a common cell surface receptor, resulting in the activation of the Jak-STAT signal transduction ...
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Mice Lacking Alpha/Beta and Gamma Interferon Receptors Are Susceptible to Junin Virus Infection
... ferrin receptor 1 (hTfR1) (22). The absence of an efficient receptor required for the virus to enter cells has been previ- ously proposed as an explanation for the resistance of labora- tory mice to JUNV ...
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The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent
... ABSTRACT Interferon alpha/beta (IFN- ␣ /  ) is a critical mediator of protection against most viruses, with host survival frequently impossible in its ... receptor complex ...
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Inhibition of Toll-Like Receptor 7- and 9-Mediated Alpha/Beta Interferon Production in Human Plasmacytoid Dendritic Cells by Respiratory Syncytial Virus and Measles Virus
... Toll-like receptor (TLR) protein family (1) and induction of cytokines that activate both innate and adaptive ...the alpha/beta interferon (IFN) system, including the group of IFN- ␣ isotypes ...
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The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus
... Conclusion. The tissue tropism and pathogenesis of viruses are determined by a combination of several factors. In the case of poliovirus infection, poliovirus replication sites are primarily determined by the presence of ...
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Human immune responses to Plasmodium falciparum infection: molecular evidence for a suboptimal THαβ and TH17 bias over ideal and effective traditional TH1 immune response
... toll-like receptor signalling, NF-κB, TNF, IFN-γ, IL-1β, p38 MAPK, MHC class I and II molecules ...of interferon gamma, NK cell cytotoxicity, antibody-dependent cell cytotoxicity (ADCC), which are triggered ...
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RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity
... the interferon-stimulated gene (ISG) promoter, whereas the wild-type (WT) control cells were not ...G9neg. Interferon-stimulated gene (ISG) expression in RIG-I KO U937-DC-SIGN cells was inhibited ...
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... lele with GG genotype. The existence of polymor- phisms in β estrogen receptor gene is indicated by changes in G to T. Subject who have a homozygous mutant allele with the TT genotype while in indi- viduals with ...
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Ross River Virus Envelope Glycans Contribute to Type I Interferon Production in Myeloid Dendritic Cells
... (alpha/beta interferon [IFN- ␣ /  ]) in myeloid dendritic cells (mDCs), where the mosquito cell-derived virus is a poor inducer of IFN- ␣ /  compared to the mammalian-cell-derived ...
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Adrenergic receptor control mechanism for growth hormone secretion
... U/kg). Beta adrenergic blockade with propranolol during insulin hypoglycemia significantly enhanced HGH concentrations in paired ...of alpha adrenergic receptor blockade on HGH concentrations could ...
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Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses
... Flaviviruses are insect-borne, positive-strand RNA viruses that have been disseminated worldwide. Their genome is translated into a polyprotein, which is subsequently cleaved by a combination of viral and host proteases ...
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Upregulation of Rarb, Rarg, and Rorc Genes in Clear Cell Renal Cell Carcinoma
... Clear cell renal cell carcinoma (ccRCC) is one of the most frequent urological malignancies with a high mortality rate. The search for genes that could be potential targets for therapy as well as diagnostic and ...
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The role of nuclear receptors in the kidney in obesity and metabolic syndrome
... PPARs are nuclear hormone receptors that stimulate tran- scription of specific genes by binding to specific DNA sequences. The three PPAR subtypes are products of the distinct genes commonly designated as PPARa, PPARc, ...
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