alpha myosin heavy chain
Changes in gene expression in the intact human heart Downregulation of alpha myosin heavy chain in hypertrophied, failing ventricular myocardium
... of alpha- myosin heavy chain mRNA (alpha-MHC, 23-34% of total), and (b) in heart failure alpha- MHC was downregulated (by 67-84%) and beta-MHC gene expression was ...substantial ...
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Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart
... supports the hypothesis that dominant negative b -MyHC mu- tations affect muscle structure and function: skeletal muscle fi- bers expressing b -MyHC missense mutations associated with FHC have abnormal contractile ...
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Androgen receptor is expressed in mouse cardiomyocytes at prenatal and early postnatal developmental stages
... During heart development, there is a dynamic expres- sion of several genes, included the alpha myosin heavy chain, Myh6, beta myosin heavy chain, Myh7, and atrial ...
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Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy
... include alpha-dystrobrevin (DTNA), Cypher/ZASP and lamin A/C ...beta-myosin heavy chain (MYH7), alpha-cardiac actin (ACTC1), cardiac troponin T (TNNT2), cardiac myosin- binding ...
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Human Adipose Tissue Derived Stem Cells as a Source of Smooth Muscle Cells in the Regeneration of Muscular Layer of Urinary Bladder Wall
... The primary antibody was diluted to the recommended concentration in 1% normal serum in PBS. The concentration was 1/100 for alpha smooth muscle actin (ASMA) and myosin heavy chain (MHC), and ...
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Specialized mouse embryonic stem cells for studying vascular development
... Abstract: Vascular progenitor cells are desirable in a variety of therapeutic strategies; however, the lineage commitment of endothelial and smooth muscle cell from a common progenitor is not well-understood. Here, we ...
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Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy Interaction between hemodynamic and thyroid hormone induced signals
... response to aortic coarctation, there was a rapid induction of the beta-MHC mRNA followed by the appearance of comparable levels of the beta-MHC protein in parallel to an increase in the left ventricular weight. ...
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Identification of a new mechanism for targeting myosin II heavy chain phosphorylation by Dictyostelium myosin heavy chain kinase B
... mammalian alpha-kinases TRPM6/TRPM7 revealed that the ability of these kinases to phosphory- late myosin II heavy chain is dependent on the autopho- sphorylation of unstructured regions of ...
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Differentiated vascular myocytes: are they involved in neointimal formation?
... muscle myosin heavy chain (Fig. 7 H) and alpha actin ...nonmuscle myosin heavy chain ...nonmuscle myosin heavy chains (Fig. 7, H and I) and alpha ...
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Masticatory (`superfast') myosin heavy chain and embryonic/atrial myosin light chain 1 in rodent jaw closing muscles
... The initial observation of the present study was the unique electrophoretic mobility of the predominant MHC isoform in samples of eastern gray squirrel masseter and temporalis muscles. This isoform had a different ...
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Two peaked increase of serum myosin heavy chain α after triathlon suggests heart muscle cell death
... specific myosin heavy chain-alpha (MHC- α ; 224 kDa compared with cardiac troponin T’s (cTnT) 37 kDa) could hardly be explained by passage through a cell ...
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GAP45 Phosphorylation Controls Assembly of the Toxoplasma Myosin XIV Complex
... the myosin XIV motor complex, protein phosphorylation and dephosphorylation are likely to affect Toxoplasma motility at several other steps, such as controlling the activity of the myosin XIV motor complex ...
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Cold-Sensitive Mutations of Dictyostelium Myosin Heavy Chain Highlight Functional Domains of the Myosin Motor
... Two of the mutants are difficult to analyze because of the changes they introduce: one is the double mutant dE467QdD595Y (references to amino acid positions in Dictyostelium [r] ...
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Myosin heavy chain gene expression in human heart failure
... because they are the molecular motors of muscle. Two types of MyHC are expressed in the mammalian heart, a - and b -MyHC. The a -MyHC has a higher ATPase activity than b -MyHC, and the contractile velocity of the heart ...
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Congenital myopathies: clinical phenotypes and new diagnostic tools
... termed myosin storage myopathy [35], is a rare condi- tion associated with mutations in a myosin heavy chain beta (MHC-β) isoform that is expressed primarily in the heart, but also in type 1 ...
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Myosin Heavy Chain Expression and Oxidative Modifications in Diabetic Rat Hearts
... only myosin heavy chain (MHC) isoform transitions, but also reduced amounts in MHC protein; and 2) if diabetes results in declines in the MHC protein content, this change would relate to oxidative ...
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Quantifying Regional-Scale Water Storage Using Models and Observations: Application For Drought Assessment In South Carolina
... be myosin heavy chain isoform shifts that occur under certain ...a myosin heavy chain isoform shift is occurring seeing as how it has a intermediate contractile speed that falls ...
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The effects of temperature acclimation on the expression of contractile protein isoforms in the skeletal muscle of the common carp (Cyprinus carpio)
... both alpha-tropomyosin and beta-tropomyosin are present in carp white ...only alpha-tropomyosin is present in carp actomyosin, and Focant et (1981), using a similar electrophoresis procedure (but with 15% ...
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Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease
... in myosin cycling kinetics imposed by Mlc2v phosphorylation-mediated mechanisms contribute to this differential regulation of epicardi- al versus endocardial tension development and ...in myosin cycling ...
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Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema
... In humans, our group and one other have demonstrated marked alterations in MHC expression in the diaphragm in severe emphysema [12,13]. This shift toward slow MHC isoforms has been proposed to subserve an adaptive ...
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