Alpha Synuclein
Alpha synuclein truncation and disease
... the alpha- synuclein-containing inclusions may not be toxic them- selves, but that the intermediate, oligomeric species along the aggregation pathway might be responsible for proteotoxicity ...in ...
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Alpha-synuclein in cutaneous small nerve fibers
... of alpha synucleinopathies, such as Parkinson’s disease (PD) and some atypical parkinsonism syndromes, is still ...of alpha-synuclein causes structural and functional damage to the nervous system is ...
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Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein
... of alpha-synuclein aggregates in the injected material as it is observed after injection with PBS [28, 29, 31, 47, ...of alpha-synuclein in the sarkosyl-insoluble fraction of the iLBD2 sample ...
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Potential Modes of Intercellular Alpha-Synuclein Transmission
... the alpha-synuclein protein result in cell loss and dysfunction in Parkinson’s disease and atypical Parkinsonism, such as multiple system atrophy and dementia with Lewy ...as alpha-synucleinopathies, ...
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Direct detection of alpha synuclein oligomers in vivo
... induced toxicity remains unknown, recent observations allude to soluble α-syn oligomers being neurotoxic [6-9]. Rat models of PD have been developed based on the putative link between alpha synuclein and ...
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Conformational changes and the self assembly of alpha synuclein
... 2012), alpha- synuclein is mainly localised to the presynaptic terminals of neurons (Iwai et ...of alpha-synuclein is largely unknown, it is believed to contribute to activity at the synapse ...
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Alpha-synuclein in cutaneous small nerve fibers
... phosphorylated alpha-synuclein-specific antibodies seem superior over native alpha-synuclein quantification, the optimal analysis technique remains ...of alpha-synuclein were ...
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Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition
... Immunohistochemical evaluation of protein levels Immunohistochemical reactions were performed using the avidin-biotin complex (ABC)/peroxidase method with mouse monoclonal antibodies anti-human HLA-DP, DQ, DR (clone ...
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Alpha synuclein in the neurodegenerative mechanisms of Parkinson's disease and dementia with Lewy bodies
... of alpha-synuclein and ubiquitin immunolabelling was assessed in non-treated (A-D) cortical neurons, and those treated with chronic oxidative stress (E- H), acute oxidative stress (I-L), chronic and ...
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Dynamic transport and localization of alpha-synuclein in primary hippocampal neurons
... We applied the exon deletion strategy to assess the structural requirements for axonal transport of a -syn. None of the individual exon deletions altered the mean transport velocity during periods of movement, nor did ...
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Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities
... Abbreviations ARTAG: ageing-related tau astrogliopathy; aSyn: alpha-synuclein; Aβ: amyloidβ; CGIs: glial cytoplasmic inclusions; DLB: dementia with Lewy bodies; FRET: Fluorescence Resona[r] ...
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Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain
... to alpha-synuclein (Cell Signaling Tech- nology and Santa Cruz Biotechnology [catalog number 69977]), rabbit polyclonal antibody to alpha-synuclein (catalog number 7011-R; Santa Cruz ...
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Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA
... aggregated alpha-synuclein ( α S) is a major characteristic of the disease, but the molecular basis distinguishing the disease-associated protein ( α S D ) from its normal counterpart remains poorly ...
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A novel extended form of alpha-synuclein 3′UTR in the human brain
... Alpha-synuclein ( α -SYN) is one of the key contributors in Parkinson ’ s disease (PD) pathogenesis. Despite the fact that increased α -SYN levels are considered one of the key contributors in developing ...
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The role of alpha-synuclein and other
... 20. Robertson, D.C.; Schmidt, O.; Ninkina, N.; Jones, P.A.; Sharkey, J.; Buchman, V.L. Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of ...
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The Toxic Interaction Of Dopamine And Alpha-Synuclein: Implications For Parkinson's Disease
... aggregation of particular proteins into pathological inclusions. The role of protein aggregation and the factors that govern neuronal susceptibility to disease have remained unclear. In Parkinson’s disease (PD), the loss ...
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Alpha-synuclein and tau: teammates in neurodegeneration?
... Several tau- and αsyn- deficient mouse lines have been generated to determine if any particular phenotype or re- sistance to neurodegeneration might be present. Gener- ally, tau- or αsyn-deficient mice are viable with ...
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Linking the structure of alpha synuclein oligmers to function in Parkinson's disease
... 1C: intracellular IDP: intrinsically disordered proteins IPD: idiopathic Parkinson’s disease IPTG: isopropyl p-D-1-thiogalactopyranoside K\ ion mobility constant K0: reduced mobility Kb:[r] ...
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Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles
... β -sheet fibril. b Structure of the micelle bound human aS, published by Ulmer et al., determined by solution NMR spectroscopy [99], highlighting the antiparallel α -helices of the membrane bound α S monomer, helix 1 ...
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Aggregation and conformation of alpha synuclein: effects of ligand binding and phosphomimetics
... Appendix 3U: +9 charge state ion of WT, S87D and S129D in the presence of equimolar CuCl2 with Gaussian fitting applied to show relative proportions of conformations C, D, E, F & G.... A[r] ...
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