Alpha-v beta-3
Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin
... integrin alpha v beta ...of alpha v beta 3 on the metastatic cells as compared to the parent ...the alpha v beta 3 receptor plays a role in the ...
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Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis
... (Fig. 3 and Additional file 1: Figure ...of alpha 5/ beta 1 and alpha v/beta 3 complexes, the integrins most involved in binding on these extracellular matrices, in shCTRL ...
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Glioblastoma expression of vitronectin and the alpha v beta 3 integrin Adhesion mechanism for transformed glial cells
... The alpha v beta 3 integrin was the only vitronectin receptor identified in glioblastoma tumors in situ, and was also not expressed on low grade astroglial-derived tumors, ...
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Exploration of peptide T7 and its derivative as integrin αvβ3-targeted imaging agents
... α v β 3 expression on the surface of eleven different cell lines was performed by FCM using antibody (ab93513; Abcam), which was monocloned based on the RGD recognizing mode (as per Abcam’s product ...
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Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin
... In this report we provide evidence that integrin av/33 is highly expressed on angiogenic vessels associated with biopsies of malignant human breast carcinoma, suggesting that integrin av[r] ...
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<p>Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target</p>
... Figure 1 The figure describes the process by which αVβ3 mediates prostate cancer cell metastasis. Macroscopically, after cancer cells destroy the ECM and leave their primary site, cancer cells depend on αVβ3, which ...
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Nanotetrac targets integrin αvβ3 on tumor cells to disorder cell defense pathways and block angiogenesis
... thyroid hormone. Covalently bound to a 200 nm nanoparticle that limits its activity to the cell exterior, tetrac reformulated as Nanotetrac has additional effects mediated by αvβ3 beyond the inhibition of binding of T 4 ...
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A concise review of magnetic resonance molecular imaging of tumor angiogenesis by targeting integrin αvβ3 with magnetic probes
... α v β ...α v β 3-positive tumor vessels by an irregular signal intensity decrease in HaCaT-ras-A-5RT3 xenografts, whereas the signal intensity decreased more homogeneously in the control tumors ...
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Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery.
... a v b 3 and a v b 5 can be differentially induced on human monocytes by the hematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating ...
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Noninvasively characterizing the different αvβ3 expression patterns in lung cancers with RGD-USPIO using a clinical 3.0T MR scanner
... Figure 3 Transmission electron microscopy images of hUVecs co-cultured with RgD-UsPIO for 10 min A) and 30 min B) or UsPIO for 30 min C) at the iron concentration of ...
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Overexpression of platelet type 12 lipoxygenase promotes tumor cell survival by enhancing alpha(v)beta(3) and alpha(v)beta(5) integrin expression
... ␣ v  5 in wild-type cells, as illustrated by an integrin-mediated adhesion assay, an effect that was not observed when cells were treated with the other LOX ...
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Integrin Alpha V Beta 3 Matrix Metalloproteinase 2 (MMP 2), Cross Talk
... breast cancer cases of different stages from the institutional hospital catchment area. Patients were offered treatment according to the stage of the disease, either surgery followed by chemotherapy and ± Radiotherapy or ...
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Integrin α<sub>v</sub>β<sub>3</sub>-targeted gold nanoshells augment tumor vasculature-specific imaging and therapy
... with similar particle concentrations ( ∼ 40 fmol) of untargeted and targeted NSs. The targeted NSs treatment group had more profound hemorrhage during treatment than the untargeted NSs treatment group. Greater amounts of ...
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Single-cell TCRseq: paired recovery of entire T-cell alpha and beta chain transcripts in T-cell receptors from single-cell RNAseq
... TCR alpha and beta chain sequences were generated for 30 pairs by randomly con- catenating variable (diversity), junction, and constant re- gions (V-J-C for alpha and V-D-J-C for ...
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High Resistance of Human Parainfluenza Type 2 Virus Protein-Expressing Cells to the Antiviral and Anti-Cell Proliferative Activities of Alpha/Beta Interferons: Cysteine-Rich V-Specific Domain Is Required for High Resistance to the Interferons
... the V protein of SV5 targets Stat1 for proteasome-mediated degradation and is thus re- sponsible for the observed block in IFN signaling in SV5- infected human cells, although SV5 does not inhibit the IFN- ...
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Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis
... hyperproliferative, alpha 2, alpha 3, alpha 6, and beta 1 were no longer confined to the basal layer, as in normal epidermis, but were also found in all the living suprabasal cell ...
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Insilico and Electron Microscope Study about Attachment of Mesenchymal Stem Cell Derived from Stromal Vascular Fraction to Scaffold (Bovine Bone Cancellous, Hydroxyapatite-Calcium Sulphate, Calcium Phosphate)
... Objective: Insilico study using molecular docking with Hex had already surpassed all of the other previous approach in assessment of molecular binding to scaffold. The combination of insilico study to investigate the ...
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Human immune responses to Plasmodium falciparum infection: molecular evidence for a suboptimal THαβ and TH17 bias over ideal and effective traditional TH1 immune response
... interferon alpha/beta was not detected in this study, the major transcription factor of interferon alpha/beta synthesis, IRF7, was up- regulated after ...interferon alpha/beta ...
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Synaptic vesicle dynamic changes in a model of fragile X
... In R statistical programming language (version 3.1.1 [17]), the MTrackJ results and background values were imported and relevant tracks were selected based on starting time point and minimum time point length. Baseline ...
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Proteomic Analysis of Celecoxib on Chondrocytes from Patients with Osteoarthritis
... subunit, alpha-actin-4 and tubulin decreased with the addition of celecoxib, while apoli- poprotein A-V, glutamate carboxipeptide 2, mitochondrial stress-70 protein, sorting nexin-9 and GRP78 increased with ...
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