Alphavirus infection
Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis
... fibroblasts. Infection rapidly triggers an innate immune response that leads to increased expression of type I interferon in skin ...following alphavirus infection activate resident macrophages to the ...
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Impact of Salmonid alphavirus infection in diploid and triploid Atlantic salmon (Salmo salar L.) fry
... Salmonid alphavirus infection is a disease that occurs after fish are transferred to seawater [27], and which can also be reproduced experimentally ...SAV infection has been studied in Atlantic ...
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Effects of Palmitoylation of Replicase Protein nsP1 on Alphavirus Infection
... the alphavirus RNA replication complexes to the cyto- plasmic surface of endosomes and lysosomes should be medi- ated by one or more of the virus-encoded nonstructural proteins nsP1 to ...in infection, when ...
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Pathogenesis of experimental salmonid alphavirus infection in vivo: an ultrastructural insight
... From the six different SAV subtypes, SAV 1 and 3 are particularly associated with pathology in the cardiovas- cular and muscular tissue of cultured salmon [10, 11]. Although, PD has been known since the early 1980s, it ...
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Identification of Genes Involved in the Host Response to Neurovirulent Alphavirus Infection
... It is also interesting that the marked increases in the expres- sion of inflammatory response genes in 10-day-old Sindbis virus-infected mouse brains were observed in the absence of histologic evidence of frank ...
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Rainbow trout (Oncorhynchus mykiss) muscle satellite cells are targets of salmonid alphavirus infection
... [15]. Infection of humans with arthritogenic alphaviruses, such as Chikungunya virus (CHIKV), Ross River virus, O’nyong-nyong virus, Sindbis virus, and others, is a global cause of debilitating musculo- skeletal ...
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Characterization of an In Vitro Model of Alphavirus Infection of Immature and Mature Neurons
... to study responses to virus infection. Consistent with previous studies (11, 23), differentiating CSM14.1 cells sequentially ex- pressed general and dopaminergic neuron-specific markers in a manner similar to that ...
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Insect response to Alphavirus infection
... mosquito cells (Aedes albopictus clones C6/36, C7-10, and U4.4) (Gliedman et al., 1975; Karpf et al., 1997a; Stollar, 1975) revealing some of the basic differences between the vertebrate and invertebrate systems (Brown, ...
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Immunobiology of an alphavirus infection in mice
... vSFV infection compared to wt B6 ...vSFV infection differs among these mouse ...Flavivirus infection with MVE has also been reported in perf''xgld mice (Licon Luna et ...
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Ribosomal Protein S6 Associates with Alphavirus Nonstructural Protein 2 and Mediates Expression from Alphavirus Messages
... after alphavirus infec- ...of alphavirus infection, we looked at the phosphorylation state of RpS6 in cells infected with alphavirus ...of infection with GFP-VRP the population of ...
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Imaging the Alphavirus Exit Pathway
... of alphavirus assembly and budding are poorly ...virus infection, E2 became enriched in localized patches on the PM and in filopodi- um-like ...Virus infection induced two distinct types of ...
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Mechanism of Tetherin Inhibition of Alphavirus Release
... efficient alphavirus restriction, a possible protective mechanism against alphavirus pathogenesis in ...Our alphavirus findings suggest that S-tetherin is restrictive only if it is capable of ...
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Spatial and Temporal Analysis of Alphavirus Replication and Assembly in Mammalian and Mosquito Cells
... Live imaging was used to track the motility of glycoprotein-containing vesicles in BHK cells. TEM analysis suggested that CPV-II traffics to the PM via the secretory pathway. Microtubule-associated core trafficking was ...
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Role of TSPAN9 in Alphavirus Entry and Early Endosomes
... CHIKV infection are responsible for millions of cases of acute illness and long-term ...internalized alphavirus, and depletion of TSPAN9 inhibited virus fusion with the early endosome ...contrast, ...
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Role for nsP2 Proteins in the Cessation of Alphavirus Minus-Strand Synthesis by Host Cells
... BHK21, alphavirus infection is lytic, viral minus-strand synthesis stops selectively 4 to 6 h after infection (43), and, once made, minus strands exist as long- lived templates engaged in plus-strand ...
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New PARP Gene with an Anti-Alphavirus Function
... of alphavirus infection in vertebrates is the induction of a high-titer viremia, which is strongly dependent on the ability of the virus to interfere with host antiviral responses on both cellular and ...
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Alphavirus evasion of type I interferons
... to alphavirus infection and succumb within days of inoculation ...post infection, we reasoned that this effect might be extended at lower doses, and therefore initially assessed replication at the 12 ...
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The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses
... that alphavirus infection is increased in Ifitm3 ⴚ/ⴚ and Ifitm locus deletion (Ifitm-del) fibroblasts and, reciprocally, reduced in fibroblasts transcomplemented with ...lethal alphavirus ...
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Early Events in Alphavirus Replication Determine the Outcome of Infection
... of alphavirus infection in vertebrate hosts is development of high-titer viremia, which is required for virus transmission to mosquito vectors during their blood ...during alphavirus replication are ...
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5656.pdf
... to alphavirus infection (165, 177, ...SINV infection, and both RIG-I and MDA5 can mediate a synergistic effect with the ISG ZAP to induce antiviral activity against SINV in vitro (165, ...during ...
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