alternative cleavage and polyadenylation
Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control
... of alternative polyadenylation (SAAP) method to identify significantly regulated APA events, as previously described ...tive polyadenylation (GAAP) was previously described in ...
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Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson’s, Alzheimer’s and ALS disease
... Raw sequencing data in the form of FASTQ files and alignment information was downloaded from the Se- quence Read Archive (SRA). GEO Accession numbers of datasets used are outlined in Table 1. FASTQ files were groomed and ...
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Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels
... from alternative cleavage and polyadenylation at four different sites – two were previously described and two are novel polyadenylation sites: one located at exon six, which confers ...
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Alternative Polyadenylation of Human Bocavirus at Its 3′ End Is Regulated by Multiple Elements and Affects Capsid Expression
... 37. Tian B, Manley JL. 2013. Alternative cleavage and polyadenylation: the long and short of it. Trends Biochem Sci 38:312–320. https://doi.org/ 10.1016/j.tibs.2013.03.005. 38. Sandberg R, Neilson ...
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Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation
... While our studies focused mainly on CFIm25, other genes were also found to regulate APA in recent studies. Large-scale tran- scriptome analysis from 2 groups identified 2 genes significantly correlated with 3′-UTR ...
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Stiff matrix instigates type I collagen biogenesis by mammalian cleavage factor I complex-mediated alternative polyadenylation
... Alternative polyadenylation (APA) is a widespread and important mechanism in regulation of gene ...UTR cleavage and polyadenylation represents a common characteristic among many disease ...
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CFIm25 and alternative polyadenylation: Conflicting roles in cancer
... APA, Alternative polyadenylation; AP1, activating protein-1; AREs, AU-rich elements; ceRNA, competing endogenous RNAs; CF, cleavage factor; CFIm and CFIIm, cleavage factor I and II; CPSF, ...
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Extensive alternative polyadenylation during zebrafish development
... by cleavage and polyadenylation (CPA) of ...undergo alternative CPA, with those from more than a thousand genes using different dominant 39 UTRs at different ...which alternative CPA ...
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E2F mediates enhanced alternative polyadenylation in proliferation
... decreased cleavage at proximal 3 ’ UTR CSs of selected target ...’ cleavage and polyadenylation activity, which leads to widespread 3’ UTR ...
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Alternative polyadenylation factors link cell cycle to migration.
... of cleavage and polyadenylation factors results in changes in isoform use and gene expression that overlap with ...of cleavage and polyadenylation factors induces a shift in isoform ...of ...
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Alternative polyadenylation factors link cell cycle to migration
... of cleavage and polyadenylation factors results in changes in isoform use and gene expression that overlap with ...of cleavage and polyadenylation factors induces a shift in isoform ...of ...
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Identification and Characterization of Two Internal Cleavage and Polyadenylation Sites of Parvovirus B19 RNA
... of alternative polyadenylation and alter- native splicing are key features that determine the relative amounts of the B19 NS and capsid ...internal polyadenylation signal, and so these RNAs must be ...
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HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6
... that two other mammalian lentiviruses, FIV and EIAV, do not interact with CPSF6-358 (18; data not shown). The role of endogenous CPSF6 in HIV-1 infection has not been determined. CPSF6 is a nuclear protein involved in ...
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Polyaseeker: a computational framework for identifying polyadenylation cleavage site from RNA-seq
... 12 To further explore the application of PolyASeeker in this dataset, a tissue-specific alternative polyadenylation study is conduct. First a 3’ UTR annotation is prepared from RefSeq Genes, which contains ...
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A comprehensive analysis of 3' end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation
... Switzerland Alternative polyadenylation (APA) is a general mechanism of transcript diversification in mammals, which has been recent- ly linked to proliferative states and ...pre-mRNA cleavage sites ...
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Developmental dynamics of gene expression and alternative polyadenylation in the Caenorhabditis elegans germline
... requirements, particularly in genes that undergo alterna- tive polyadenylation. This suggests either that the CPA machinery is less stringent or that additional sequence features and/or cleavage factors ...
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Landscape and evolution of tissue specific alternative polyadenylation across Drosophila species
... Conservation and evolution of APA in Drosophila Conservation of sites of cleavage and polyadenylation has been investigated in mammalian systems [35], show- ing conservation of tissue-specific patterns. ...
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NUDT21 inhibits bladder cancer progression through ANXA2 and LIMK2 by alternative polyadenylation
... the cleavage factor Im (CFIm) complex that participates in the assembly of eukaryotic pre-mRNA ...proximal cleavage and polyadenylation site, and directing APA ...
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Unique Features of Nuclear mRNA Poly(A) Signals and Alternative Polyadenylation in Chlamydomonas reinhardtii
... recruiting polyadenylation factors and determining the position of ...GU-rich polyadenylation signal that serves as another binding site for polyadenylation factors (G ilmartin ...the cleavage ...
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Endothelin-Converting Enzyme-1 (ECE-1) Is Post-Transcriptionally Regulated by Alternative Polyadenylation
... Here we provide evidence that the ECE-1 39UTR contains APA sites, and that these may be used to generate truncated transcripts in prostate cancer cells. Heterologous expression of constructs containing truncations ...
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