Alveolar Epithelial Cell
TRIM72 promotes alveolar epithelial cell membrane repair and ameliorates lung fibrosis
... fixable cell vitality dye eFluor450 (blue) and post-fixation immunostaining of p53 (red) in these cells; blue arrows = p53+ FITC+ or p53 + eFluor+ cells; scale bar = 20 μ m; b the number of p53 positive cells per ...
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TAZ is required for lung alveolar epithelial cell differentiation after injury
... in alveolar repair after acute Streptococcus pneumoniae infection was published ...inadequate alveolar repair after acute injury contributed to increased fibrogenesis; in contrast to our findings, ...
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Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers
... PEGylated quantum dots (CdSe/ZnS, core size 5.3 nm, hydrodynamic size 25 nm) which were non-modified, amine-modified, or carboxylate-modified, were purchased from eBioscience (San Diego, CA). Excitation/emission ...
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β1 Integrin regulates adult lung alveolar epithelial cell inflammation
... where epithelial cells undergo slow turnover and are tightly bound to the basement ...in alveolar epithelial cells has an antiinflammatory role and is required for alveolar homeostasis in the ...
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Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)
... determined. Cell name: A549: human lung adenocarcinoma alveolar epithelial cell line; ATII: primary human alveolar type-II epithelial cells; BALB-3 T3: mouse embryonic fibroblast ...
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Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia—a new therapeutic strategy?
... AEC, alveolar epithelial cell; Ag, antigen; ALI, acute lung injury; AM, alveolar macrophage; ARDS, acute respiratory distress syndrome; BALF, bronchoalveolar lavage fluid; c-Met, hepatocyte ...
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Mac-1 deficiency induces respiratory failure by affecting type I alveolar epithelial cells.
... each alveolar epithelial cell type were ...I alveolar epithelial cells, the number of which was consequently reduced, eventually leading to respiratory ...
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TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
... myofibroblast-like cell induction [5] and TGF-β1 continues to be regarded as the most impor- tant of the growth factors involved in pulmonary fibro- genesis ...the epithelial cells lin- ing honeycomb cysts ...
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Rosiglitazone promotes ENaC-mediated alveolar fluid clearance in acute lung injury through the PPARγ/SGK1 signaling pathway
... various cell signaling pathways and phosphoryl- ation cascades, playing important roles in ion channels, the cellular stress response, and cell ...precursor cell-expressed developmentally downregu- ...
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Migrating leukocytes are the source of Peroxiredoxin V during inflammation in the airways
... the alveolar epithelial cell line A549, co-cultured with mouse macrophage cell line ...the epithelial cells in cul- ture, which is similar to our findings in ...thelial ...
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GABA receptor ameliorates ventilator induced lung injury in rats by improving alveolar fluid clearance
... causes epithelial damage, oxidative stress, surfactant inactivation, and pul- monary edema ...clear alveolar fluid in rats after injurious mechanical venti- lation ...
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Alveolar Type II Epithelial Cells Contribute to the Anti Influenza A Virus Response in the Lung by Integrating Pathogen and Microenvironment Derived Signals
... cells for IAV replication (5, 6). AECII cover about 5% of the alve- olar surface, while they comprise about 60% of the alveolar lining cells and 15% of the parenchymal cells (7). Until recently, the secretion of ...
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Characterising epithelial to mesenchymal transition and pro fibrotic processes in chronic obstructive pulmonary disease
... stained alveolar tips (free inter alveolar septa), than smokers with normal lung ...2013). Epithelial cells (alveoli) and endothelial cells (blood vessels) are located in very close proximity to one ...
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Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury
... [21]. Pulmonary edema, which is a major feature of ARDS, is associated with the malfunction of two lung cellular barriers: epithelial and endothelial cells [22]. Quercetin has been shown to improve the barrier ...
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Endothelial mitochondria determine rapid barrier failure in chemical lung injury
... induces alveolar inflammation, leading to life-threatening pulmonary ...By alveolar micropuncture, we microinfused concentrated HCl in the alveolar ...-mediated epithelial-endothelial ...
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Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation
... T cell mediated lung inflammation, we made use of a transgenic mouse model of chronic T cell mediated lung inflammation that mimics some of the fea- tures of the interstitial lung discussed above, and that ...
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Original Article Paradoxical function for the receptor for advanced glyca- tion end products in mouse models of pulmonary fibrosis
... 60 min. The non-adherent ATII cells were re- moved by gentle washing and collected while the hematopoetic cells remained tightly ad- hered to the plates. The cells were pelleted by centrifugation at 130x g and then ...
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Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function
... Results: Stereological analysis revealed decreased alveolar number density, elastin to collagen ratio and increased mean alveolar volume in C3H/HeJ mice compared to JF1/MsJ. Gene ontology term “ ...
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rcmb.2017-0019oc.pdf
... to epithelial repair through modulation of another cell type cannot be completely excluded, but the in vitro coculture experiments support a direct interaction and effect of Treg-expressed kgf on AT2 ...
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Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung
... as cell death in A549 cells upon hyperoxia exposure in a dose-dependent manner ...primary alveolar epithelial Type II cells led to increased sensitivity to TGFβ-induced apoptosis ...
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