ALVEOLAR TYPE-II
Interleukin 10 Down Regulates Cathepsin B Expression in Fetal Rat Alveolar Type II Cells Exposed to Hyperoxia
... fetal alveolar type II cell (FATI- IC) death and pretreatment of recombinant IL-10 (rIL-10) attenuates type II cell death during ...rat alveolar type II cells were ...
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Effects of Perfluorocarbons on surfactant exocytosis and membrane properties in isolated alveolar type II cells
... Perfluorocarbons (PFC) that are used to improve gas exchange in diseased lungs with disturbed pulmonary surfactant system affect various cell types [1-4]. Thus, an effect on alveolar type II (ATII) ...
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Effect of exogenous surfactants on viability and DNA synthesis in A549, immortalized mouse type II and isolated rat alveolar type II cells
... Mouse cells: The immortal mouse alveolar type II cells (iMATII) were obtained from the original developing laboratory [14]. iMATII cells were seeded on human collagen IV (5 μ g/cm²) coated cell ...
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Gold nanoparticles induce cytotoxicity in the alveolar type-II cell lines A549 and NCIH441
... In conclusion, our results suggest that the presence of con- taminants, such as sodium citrate, affects the viability and the proliferation of the human alveolar type-II-like cell lines A549 and ...
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Alveolar type II epithelial cells produce interleukin 6 in vitro and in vivo Regulation by alveolar macrophage secretory products
... Rat alveolar macrophage conditioned media (CM) increased IL-6 secretion by rat ATII cells through the effect of IL-1 and ...human alveolar macrophages and THP1 cells ...
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LysoTracker is a marker of differentiated alveolar type II cells
... LysoTracker resolves 14.1% of viable hematopoietic cells (CD45 pos CD31 neg EpCAM neg Figure 1A), 8.3% of viable endothelial cells (CD45 neg CD31 pos EpCAM neg Figure 1B), 73.7% of viable epithelial cells (CD45 neg CD31 ...
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Alveolar Type II Epithelial Cells Contribute to the Anti Influenza A Virus Response in the Lung by Integrating Pathogen and Microenvironment Derived Signals
... TLR7 deficiency alters the regulation of gene expression in AECII. We hypothesized that the host relies on IAV-sensing PRR in order to mount a full AECII response and analyzed transcrip- tional regulation in lungs and ...
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Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis
... As reported in neuronal diseases, a severe ER stress response can lead to neuronal cell death [16,40]. Recent studies on ER stress-mediated neuronal apoptosis have also shown involvement of ERp57 in disulfide-mediated ...
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Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats
... by alveolar type II epithelial cells in response to LPS is similar to that produced by alveolar macrophages, but is lower in quantity (Kanj, Kang, & Castranova, ...LPS-exposed ...
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Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell
... and alveolar type II cells were ...isolated alveolar type II cells to discover alterations in cellular pathways at the protein level that might contribute to ...in ...
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Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)
... AM: alveolar macrophages; AO: adverse outcome; AOP: adverse outcome pathway; ATII: primary human alveolar type-II epithelial cells; BEAS-2B: bronchial epithelial cells; BEAS-2B: human ...
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Zinc oxide nanoparticle-induced atherosclerotic alterations in vitro and in vivo
... human alveolar type II epithelial cells (A549), then levels of interleukin-8 (IL-8), tumor necrosis factor- α (TNF- α ), heme oxygenase-1 (HO-1), and atherosclerotic biomarkers including platelet ...
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Metabolism of platelet activating factor in isolated perfused rat lung
... metabolism into lyso-PAF (3.3%), phosphatidylcholine (82.3%), neutral lipid (1.7%) and intact PAF (10.2%). Analysis of tissue phosphatidylcholine by mass spectrometric techniques revealed metabolism of PAF to ...
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Mesenchymal stem/stromal cells: the therapeutic effects in animal models of acute pulmonary diseases
... the alveolar epithelium, followed by accumulation of protein-rich fluids, cellular lesions in the alveolar space and the inflammation of airways that cause resistance to air flow and the lung capacity ...
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Case Report Primary pleomorphic adenoma of the lung with positive staining of TTF-1: a case report and review of literature
... The present case showed typical structure of pleomorphic adenoma. The diagnosis was not difficult. But, the specific character of this ca- se was that the tumor epithelial cells were po- sitive for TTF-1 staining. TTF-1 ...
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Regeneration of the lung: Lung stem cells and the development of lung mimicking devices
... AT- II cells, indicating that other cell sources also contribute to re-alveolarization ...cell type can be induced by changing the expression of a single ...its alveolar cell type to a more ...
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rcmb.2017-0019oc.pdf
... development, wound healing, cellular proliferation, and differentiation (47). There are 22 known Fgfs and 4 Fgf receptors (47). kgf (Fgf-7) signals through the Fgfr2b receptor (47). Administration of recombinant kgf in ...
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Endothelial-monocyte activating polypeptide II disrupts alveolar epithelial type II to type I cell transdifferentiation
... EMAP II plays a significant and leading role ...EMAP II mechanis- tically influences distal alveolar differentiation versus death are essential in being able to develop therapeutic strategies to ...
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Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis
... self promotes trans-differentiation of these cells and seem to interfere with a TGFβ-mediated effect in AECII. These results are perfectly in line with our in vitro observations and strengthen the observation that pri- ...
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Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function
... All procedures were approved by the Bavarian Animal Research Authority, Animal Research Authority of Schleswig-Holstein, and University of Pittsburgh, PA. Frozen and paraffin embedded tissues were procured to carry out ...
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