aminoglycoside antibiotics
Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″) Ia
... existing antibiotics against re- sistant strains of ...of aminoglycoside-modifying enzymes, and to thus rejuvenate the activity of the aminoglycoside antibiotics against Gram-negative ...
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TpiA is a Key Metabolic Enzyme That Affects Virulence and Resistance to Aminoglycoside Antibiotics through CrcZ in Pseudomonas aeruginosa
... Since the tpiA mutant shows a growth defect, secondary mutations could occur to compensate the fitness defect. To further confirm that the phenotypes of the mutant strains are related to tpiA and crcZ, the strains used in ...
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Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice
... Although gene therapy is seen as the future hope for the treatment of DMD and other genetic diseases (25, 26), aminoglycoside antibiotics offer a different and immediate approach to the treatment of genetic ...
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Tolerance of Norway spruce (Picea abies [L ] Karst ) embryogenic tissue to penicillin, carbapenem and aminoglycoside antibiotics
... tive antibiotics preventing bacterial overgrowth and also antibiotics suitable for selective media having minimal damaging effects on the growing embryonic tissue during somatic embryogenesis is an ...
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Identification and Evaluation of Improved 4′ O (Alkyl) 4,5 Disubstituted 2 Deoxystreptamines as Next Generation Aminoglycoside Antibiotics
... of aminoglycoside- dependent inhibition of luciferase synthesis were analyzed to de- fine the drug concentrations required to inhibit in vitro synthesis of functional firefly luciferase to 50% (IC 50 ...
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Potentiation of Clostridium botulinum Toxin by Aminoglycoside Antibiotics: Clinical and Laboratory Observations
... romuscular weakness caused by botulinum toxin, and suggest that these antibiotics should be used with caution in suspected cases of infant botulism. ACKNOWLEDGMENTS[r] ...
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Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons
... AAGs: Aminoglycoside antibiotics; eRF1/3: Eukaryotic release factor 1/3; GTTR: Texas Red-tagged gentamicin; N c-tRNA: Near-cognate tRNA; NMD: Nonsense-mediated mRNA decay; NTC: Normal te[r] ...
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Structure based design of a eukaryote selective antiprotozoal fluorinated aminoglycoside
... (Supplementary Figure 2a), we hypothesized that: (i) interactions of 6’-F sisomicin with the bacterial ribosome A-site should be disrupted due its inability to form a stable pseudo base-pair interaction with the A1408 ...
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Prescribing practices for intravenous aminoglycosides in UK cystic fibrosis clinics: a questionnaire survey
... Intravenous aminoglycoside antibiotics are widely used to treat pulmonary infection with Pseudomonas aeruginosa in individuals with cystic fibrosis ...of aminoglycoside and the dosing regimen may ...
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Identification of clinically antibiotic resistant genes Aac(3)-IIa and Aac(6’)-Ib in wastewater samples by multiplex PCR
... Aminoglycoside antibiotics are widely used in medical clinics, especially to treat life-threating infections caused by gram-negative bacteria ...of aminoglycoside resistance and the resulting ...
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Studies on antibiotic synergism against enterococci: II Effect of various antibiotics on the uptake of 14C labeled streptomycin by enterococci
... with aminoglycoside antibiotics has not been ...this aminoglycoside antibiotic was markedly enhanced in enterococci growing in the presence of penicillin or other agents which inhibit the synthesis ...
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... As shown by Table 4, although not significantly associated, self-medication practices were more prevalent in those whose family income were less than Rp 2.500.000 (OR=1.94; 95% CI= 0.89–4.20). Although inability to pay ...
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A solution to combat aminoglycoside and quinolone resistant gram negative organisms
... Antimicrobial susceptibility testing was done by Kirby–Bauer disk diffusion method as recommended by the Clinical Laboratory Standards Institute (CLSI) guidelines (2013). The discs of following drugs gentamicin (10 μg), ...
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Extended-Interval Aminoglycoside Administration for Children: A Meta-analysis
... setting, aminoglycoside type, total daily dose, dosing intervals in the MDD arm, concur- rent use of other antibiotics, definitions of clinical and bacterio- logic failure, nephrotoxicity and ototoxicity, ...
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Nebulized antibiotics for ventilator associated pneumonia: a systematic review and meta analysis
... Methods: The Medline, Scopus, EMBASE, Biological Abstracts, CAB Abstracts, Food Science and Technology Abstracts, CENTRAL, Scielo and Lilacs databases were searched to identify randomized controlled trials or matched ...
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BIOCHEMICAL ROLE OF ELECTROLYTE EXCRETION IN AMINOGLYCOSIDE NEPHROTOXICITY
... of aminoglycoside-induced renal damage however, exaggerated standard error of mean (SEM) values was observed, associated with these urinary excretion of electrolytes, hence it is not a sensitive biochemical ...
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Antibiotics and resistance
... Mechanism of action include: Inhibition of cell wall synthesis Inhibition of protein synthesis Inhibition of nucleic acid synthesis Inhibition of metabolic pathways Interfere[r] ...
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In Vivo Evaluation of Aminoglycoside Induced Nephrotoxicity and Hepatotoxicity in Albino Rats
... for aminoglycoside induced renal and hepatic ...with aminoglycoside such as amikacin leads to a significant free radical generation which leads to oxidative stress, resulting into a significant hepatic and ...
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Vancomycin Resistant Enterococci in Preterm Neonates: A Rising Thunder in Intensive Care Units
... level Aminoglycoside resistance (78 %) in Enterococcal neonatal septicemia (16 %), considered as only colonizers ...higher antibiotics like Linezolid, Daptomycin, Teicoplanin should be ...
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Staphylococcus aureus adaptation to aerobic low-redox-potential environments: implications for an intracellular lifestyle
... aureus aerobic respiration was impaired, the intracellular 26 NADH:NAD+ ratio increased, lactate dehydrogenase was induced, resistance to the 27 aminoglycoside antibiotic gentamicin was [r] ...
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