AMP-activated protein kinase α
Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487
... anti-protein kinase C (PKC)α, anti-PKCζ, anti-phospho-protein kinase D (PKD)/PKCm (Ser916), anti-PKD/PKCm antibodies and mouse anti-Akt, anti-phospho-ERK1/2 (Thr202/Tyr204) antibodies ...
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Deficiency of iNOS-derived NO accelerates lipid accumulation-independent liver fibrosis in non-alcoholic steatohepatitis mouse model
... AMPK: AMP-activated protein kinase; PPAR- α : Peroxisome proliferators-activated receptor alpha; NAFLD: Non-alcoholic fatty liver disease; IR: Insulin resistance; NAFL: ...
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Molecular networks in skeletal muscle plasticity
... AMPK, AMP-activated protein kinase; AP-1, activator protein 1; Ang, angiopoietin; BAX, apoptosis regulator Bax (regulated by tumor suppressor protein p53); CaM, calmodulin; CaMK, ...
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A possible role for AMP-activated protein kinase activated by metformin and AICAR in human granulosa cells
... of protein was applied per ...phospho-p70S6 kinase, rabbit poly- clonal immunoglobulin G, human phospho-IκB-α, mouse monoclonal immunoglobulin G (IgG; Cell Sig- naling Technology), and human ...
8
Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase
... (TNF α , IL-1 β , and IL-18) and decrease of anti-inflammatory cytokine (IL-10) in PCOS rats were suppressed by ...AMPK protein level and phosphorylation, the decrease of Akt phosphorylation and the ...
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AMP activated protein kinase: the guardian of cardiac energy status
... creatine kinase promoter, which provided evidence that AMPK regulated glucose uptake in skeletal muscle in vivo ...catalytic α subunit, a β subunit with a glycogen-binding domain (10, 11) and a γ subunit ...
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AMP-activated protein kinase regulates L-arginine mediated cellular responses
... The AMP-activated protein kinase (AMPK) [22], a protein consisting of three subunits α, β, and γ, is an important energy-sensing/signaling system by which cells sense and decode ...
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Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase
... AMPK α , we wondered whether other well-documented NESs would function in lieu of the AMPKα carboxy-tail ...while protein kinase A inhibitor (PKIA) contains a distinct but also well-characterized NES ...
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Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet
... proliferator- activated receptor (PPAR)- γ , sterol regulatory element- binding protein (SREBP)-1c, and fatty acid-binding protein 2 (aP2), were analyzed in white adipose tissue ...PPAR- α , ...
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AMP-activated protein kinase is required for the anti-adipogenic effects of alpha-linolenic acid
... At protein level, mitochondrial genes (peroxisome proliferator-activated receptor gamma coactivator 1 alpha [PGC1 α ] and nuclear respiratory factor-1 [nrf1]) and β -oxidation related genes ...
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Role of AMP activated protein kinase in mechanism of metformin action
... AMP activates AMPK by promoting its phosphorylation at Thr 172 and by direct activation via an allosteric AMP site. Since enzyme activity shown in Figure 1, a and b, was measured after precipitation from ...
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AMP-Activated Protein Kinase Is Required for the Macropinocytic Internalization of Ebolavirus
... or AMP. As these anabolic by-products accumulate, AMP binds to the ␥ sub- unit of AMPK and causes structural changes and subsequent phosphorylation of Thr172 in the catalytic subunit, which is re- quired ...
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Metformin induces apoptotic cytotoxicity depending on AMPK/PKA/GSK-3β-mediated c-FLIP<sub>L</sub> degradation in non-small cell lung cancer
... reported that metformin promoted c-FLIP L degradation in bladder cancer and lung cancer, respectively, thus resulting in synergism of TRAIL-induced cytotoxicity, but whether metformin also influences the expression of ...
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LKB1 and AMPK and the cancer-metabolism link - ten years after
... upstream kinase acting on AMP-activated protein kinase (AMPK) as a complex containing LKB1, a known tumor ...a protein kinase, AMPK, which at the time was mainly ...
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Hinrichs, Arne (2018): Generation and characterization of a pig model for Laron syndrome. Dissertation, LMU München: Tierärztliche Fakultät
... the kinase domain of the other JAK2 and vice versa [74]. The kinase domains of the 2 JAK2 molecules can then be transactivated and initiate tyrosine phosphorylation of the GHR cytoplasmic domains and STAT5, ...
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Activation of mTOR: a culprit of Alzheimer’s disease?
... p70S6 Kinase), suppres- sion of autophagy (Atg13, ULK1), ribosome biogenesis, and activation of transcription leading to mitochondrial metabolism or ...(PKC) protein kinase ...
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Flavonoids as inducers of white adipose tissue browning and thermogenesis: signalling pathways and molecular triggers
... Quercetin is extracted from onion peel and has been demonstrated to have many biological functions, such as antioxidant, anti-inflammatory and anti-obesity effects [70]. Many studies have demonstrated that quercetin ...
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AMP activated protein kinase: a potential therapeutic target for triple negative breast cancer
... action. AMP-activated protein kinase (AMPK), an energy sensor, can regulate protein and lipid metabolism responding to alterations in energy ...
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The regulation of heart AMP-activated protein kinase by long-chain fatty acids and hormones
... with protein concentration (Dyck JRB et ...casein kinase II, AMPK, PKC or protein phosphatases 2A and 2C produced no change in enzyme ...by protein phosphatase 2A ...
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Mesoglycan attenuates VSMC proliferation through activation of AMP-activated protein kinase and mTOR
... Background: Vascular smooth muscle cells (VSMC) proliferation contributes significantly to intimal thickening in atherosclerosis and restenosis diseases. Platelet derived growth factor (PDGF) has been implicated in VSMC ...
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