AMPA receptors
Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs
... of AMPA receptors at high Pr synapses and a compensatory increase in the surface expression of AMPA receptors at low Pr ...synaptic AMPA receptors, and also conserved the ...
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The involvement of ionotropic AMPA receptors in the pathogenesis of neurological diseases
... functional AMPA receptors, activation o f which can lead to TNFa release (Noda et aL, 2000) which itself is potentially harmful (Taupin et aL, ...in AMPA channel configuration can change the ...
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A human PET study of [11C]HMS011, a potential radioligand for AMPA receptors
... Noncompetitive AMPA antagonists suggested to be more beneficial than competitive AMPA antagonists in the treatment of seizure, as their effectiveness is un- affected by high endogenous glutamate ...
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MORPHINE RELE ASES GLUTAMATE THROUGH AMPA RECEPTORS IN THE VENTRAL TEGMENTAL AREA: A MICRODIALYSIS STUDY IN CONSCIOUS RATS
... release from the ventral tegmentum area (VTA) in freely moving rats. Intraperito neal (i.p.) injection of acute and repeated morphine at increasing doses signifi cantly enhanced glutamate release. Only a minor ...
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Removal of Synaptic Ca2+ Permeable AMPA Receptors during Sleep
... in AMPA receptor composition at excitatory cortical synapses with CP-AMPARs being present after the dark episode and being undetectable after the light ...functional AMPA receptors participating in ...
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Long-term upregulation of cortical glutamatergic AMPA receptors in a mouse model of chronic visceral pain
... of AMPA receptors to plasma membrane The results above showed the key role of AMPA recep- tor in the ACC of mice with chronic visceral ...increased AMPA receptors in the ACC of mice ...
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Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions
... NMDA receptors, AMPA receptors do not appear to be strongly regulated by overexpression of mouse or human PrP C , and these data are consistent with our earlier synaptic work in PrP C null mouse neu- ...
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Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA2 balance
... the AMPA receptors, merging vesicles with the synaptic ...their AMPA receptors toward the lysosomal degradation pathway ...of AMPA receptor expression levels, ARA mobilization, and ...
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Peripheral calcium permeable AMPA receptors regulate chronic inflammatory pain in mice
... Peripheral GluA1-containing AMPARs as pharmacological targets to attenuate inflammatory pain? Although a few studies have reported antinociceptive effects with nonspecific antagonists of non-NMDA glutamate ...
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Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors
... Protein kinase M zeta (PKM ζ ), a constitutively active, atypical protein kinase C isoform, maintains a high level of expression in the brain after the induction of learning and long-term potentiation (LTP). Further, its ...
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Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia
... tTA:CHMP2B Intron5 mice had a lower rectification index than those of tTA:CHMP2B WT mice (Fig. 3c), suggesting an increased proportion of Gria2-containing receptors. Moreover, at a concentration of 200 μM, Naspm ...
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Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity
... N-methyl-D-aspartate receptors (NMDAR) and α -amino-3-hydroxyle-5-methyl-4- isoxazolepropionic acid receptors (AMPAR), which are primary mediators of excitatory synaptic ...
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PDZ Proteins interacting with c terminal GluR2/3 are involved in a PKC dependent regulation of AMPA receptors at hippocampal synapses
... 5-methylisoxazole-4-propionic acid receptor GluR1 subunit. J. Biol. Osten, P., Srivastava, S., Inman, G.J., Vilim, F.S., Khatri, L., Lee, Chem. 273, 19518–19524. L.M., States, B.A., Einheber, S., Milner, T.A., Hanson, ...
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Modulation of the AMPA Receptor by Membrane cholesterol and neuroactive steroids
... glutamate receptors is currently viewed as one of the plausible mechanisms for modifications of synaptic efficacy that underlie learning and ...postsynaptic AMPA/kainate response (Bliss and Collingridge, ...
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Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor
... . AMPA receptors are ubiquitous in the CNS and mediate the majority of fast amino acid ...of AMPA receptors in brain physiology, a lot of early effort in terms of pharmaceutical drug ...
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Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning
... In order to determine if the rapid membrane bound GluA1 upregulation observed within the ACC of mice exposed to trace fear conditioning corresponds to functional CP- AMPARs, we assessed the contribution of CP-AMPA ...
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A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia
... Horsch and colleagues performed behavioral analysis of homozygous Adar2 knockout mice under the back- ground of homozygous knock-in alleles of an edited ver- sion of Gria2 to rescue severe phenotypes due to loss of Q/R ...
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“Herbal Extract as Potential Modulator and Drug for Synaptic Plasticity and Neurodegenerative Disorders” by Ashish Thapliyal, Prabhakar Semwal, Taranjeet Kapoor, Prashant Anthwal, Bipin Sati, Ashish Thapliyal, India.
... NMDA receptors and Ca 2+ It is well accepted that the induction of LTP requires activation of post synaptic NMDA (N-methyl-D-aspartic acid receptors, a sub type of glutamate receptor) during post synaptic ...
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Regulation of Ion Channel and Transporter Function Through RNA Editing
... these receptors open a cation selective pore, allowing extracellular Na⁺, and sometimes Ca²⁺, to enter the cell, causing a transient ...glutamate receptors are an exceptionally diverse gene ...glutamate ...
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The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease
... of AMPA receptors through its interaction with the endocytic machin- ery [41], and is believed to regulate an endosomal pathway involved in the generation of activity-dependent amyloid- beta (Aβ) deposits ...
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