amyloid P component
The pentraxins, C reactive protein and serum amyloid P component, are cleared and catabolized by hepatocytes in vivo
... serum amyloid P component (SAP), a universal constituent of amyloid deposits, were sought using the ligand 125I-tyramine cellobiose (TC) which is substantially retained within the cells in ...
8
Original Article Serum amyloid P component regulated the development of diabetic nephropathy via down regulation of CCL-1
... Abstract: Serum amyloid P component (SAP) is a plasma protein which has calcium-dependent binding activity and belongs to the pentameric protein family. It is mainly regulated in the inflammation in ...
6
Influenza Virus Infection is not Affected by Serum Amyloid P Component
... serum amyloid P component (SAP) to its ligands, including bacteria, chromatin and amyloid fibrils, protects them from degradation, is anti- opsonic and ...
7
Serum amyloid P component therapeutically attenuates atherosclerosis in mice via its effects on macrophages
... Serum amyloid P component (SAP), a member of the pentraxin protein family, is mainly secreted from the liver and macrophages into the circulation [1, ...
10
Serum Amyloid P Component Binds Fungal Surface Amyloid and Decreases Human Macrophage Phagocytosis and Secretion of Inflammatory Cytokines
... serum amyloid P component (SAP) (also called PTX2) to Candida al- bicans dampens the innate immune response to this ...surface amyloid-like structures important for adhesion and biofilm forma- ...
14
Metabolic studies of radioiodinated serum amyloid P component in normal subjects and patients with systemic amyloidosis
... 125I-Serum amyloid P component (SAP), injected intravenously into 10 normal subjects, remained predominantly intravascular with mean (SD) T1/2 (half time) in plasma of ...
9
Human Serum Amyloid P Component is a Single Uncomplexed Pentamer in Whole Serum
... with amyloid deposits in ...protects amyloid fibrils against proteolysis in ...develop amyloid normally (18–20). The SAP-amyloid interaction is, thus, a novel and intriguing therapeutic ...
12
Selected expression profiling of full-length proteins and their variants in human plasma
... sion profiling of a select group of proteins— C-reactive proteins (CRP), retinol binding pro- tein (RBP), and serum amyloid P component (SAP) (and their variants)—present in human plasma. The central ...
10
Verification of foetal Down syndrome biomarker proteins in maternal plasma and applications in prenatal screening for Down syndrome
... promote amyloid deposition β that causes age spots and excessive phosphorylated tau protein that forms tangles in nerve cells, while neurons inhibit glial cell hyper- plasia ...with amyloid pla- ques, which ...
8
Identification of psoriatic arthritis mediators in synovial fluid by quantitative mass spectrometry
... APCS: Amyloid P component; APOC1: Apolipoprotein C1; C4BP: C4b-binding protein; CASPAR: Classification and diagnostic criteria for psoriatic arthritis; CD5L: CD5-like protein; CRP: C-rea[r] ...
12
<p>Vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints</p>
... the relationships between selected imaging marker(s) and SMCQ score, we also tested multiple linear regression model(s) including imaging marker × VR score interaction term as well as imaging maker(s) and VR score as ...
9
Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
... Amyloid precursor protein (APP) is an evolutionarily conserved protein with two homologues in mammals: amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) [1, 2]. ...
15
<p>Amyloid Beta (A4) Precursor Protein: A Potential Biomarker for Recurrent Nasopharyngeal Carcinoma</p>
... A preliminary analysis was performed to assess the poten- tial value of APP as a serum biomarker for rNPC. The serum samples of 70 patients with NPC (35 rNPC + 35 nrNPC) were initially collected because some samples ...
6
Effects of age of onset on clinical characteristics in schizophrenia spectrum disorders
... two analytical approaches were applied in our study. Spearman’s correlation coefficient was used to assess relationships between the age of illness onset and insight into illness, psychopathology, symptom rating scales, ...
11
Human Cerebrospinal Fluid Apolipoprotein E Isoforms are Apparently Inefficient at Complexing with Synthetic Alzheimer’s Amyloid-β Peptide (Aß1−40) in vitro
... brain amyloid plaques (8,9), the existence of SDS-resistant apoE/Aß complexes in AD brain (10), and the increased amyloid plaque density in AD patients and nondemented elderly individuals carrying an 4 ...
6
Altered glycosylation profile of purified plasma ACT from Alzheimer’s disease
... ACT plays a role in the modulation of brain amyloid deposition and immune responses, both processes are thought to be important contributors to the pathogen- esis of AD [21]. Inflammatory states are usually asso- ...
8
Characterization of the protein component of Methanococcus jannaschii RNase P
... RNase P RNAs from Archaea vary in their ability to cleave premature tRNA (pre-tRNA) in vitro in the absence of protein and those RNAs that can cleave substrate only do so with high salt concentration ...RNase ...
77
Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... vascular amyloid or senile plaques from AD and Down’s syndrome patients, the identifi cation of APP was a logical step forward ...vascular amyloid - the chromo somal location of APP also strongly argued in ...
14
Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... indications were found according to the laboratory and imaging results. Lesions on T2/FLAIR revealed obvious edema and no lesion was enhanced in MRI gadolinium enhancement, which was similar to low-grade glioma and ...
6
Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs
... Despite the above concerns and challenges, it should be recognized that BACE1 is perhaps the best target for reducing Aβ generation, considering the relatively mild phenotypes exhibited by BACE1-null mice. This may be ...
11