amyloid-β (1–42)
The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
... the amyloid-β protein (Aβ) was isolated from brains with amyloid depositon and it was subsequently identified as the core protein of neuritic plaques ...from amyloid-β precursor protein ...
8
Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation
... site(s) on APP, producing longer Aβ spe- cies (13). Hence, we refer to this state as “closed,” pathogenic PS1 conformation. Importantly, pathogenic PS1 conforma- tion, elevated production of the longer, fibrillogenic Aβ ...
9
Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease
... A group of experts in the field of AD biomarkers were brought together, and several meetings of this working group were conducted. During the meetings, discussions took place based both on evidence gathered from scien- ...
15
Amyloid-β 1–24 C-terminal truncated fragment promotes amyloid-β 1–42 aggregate formation in the healthy brain
... right). Notably, ELISA for the C-terminal domain of the protein revealed that the modifications in the nature of the extracellular amyloid fragments were prevented by microglia incubation with protease inhibitors ...
19
Insights into the roles of lncRNAs in skeletal and dental diseases
... Aβ 1-42: amyloid-β 1-42; BACE1: β-secretase-1; BMSC: bone marrow stem cell; BMP-2: bone morphogenetic protein 2; CDCP1: CUB-domain-containing protein 1; ...
10
A dual brain-targeting curcumin-loaded polymersomes ameliorated cognitive dysfunction in intrahippocampal amyloid-β<sub>1–42</sub>-injected mice
... Abstract: Due to the impermeability of the blood–brain barrier and the nonselective distribution of drugs in the brain, the therapeutic access to intractable neurological disorders is challenging. In this study, dual ...
11
Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab
... Finally, three human VH Fr residues in v1 of humanized 3D6 were converted to germline A75S, S78T and L93V based on the sequence of the closest human germline VH region (V3-23), leading to version two of humanized 3D6 ...
13
Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer’s disease
... spinal fluid (CSF) and amyloid positron emission tomog- raphy (PET) imaging [1]. Recently, these methods have been used widely in the clinical setting; however, they have several disadvantages, such as ...
10
No added diagnostic value of non-phosphorylated tau fraction (p-taurel) in CSF as a biomarker for differential dementia diagnosis
... while there are other phosphorylated tau epitopes that have not been thoroughly investigated for their clin- ical utility such as serine 199 and threonine 231 [4]. Although studies on large neuropathology case series ...
7
Aβ43 in human Alzheimer’s disease: effects of active Aβ42 immunization
... of Amyloid- β 42 (A β 42) immunization (AN1792, Elan Pharmaceuticals) has shown that immunization can induce removal of A β 42 and A β 40 from plaques, whereas ...
11
Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
... A β : amyloid β peptide; AD: Alzheimer ’ s disease; APH-1: anterior pharynx- defective 1; APP: amyloid β precursor protein; BACE-1: β -site amyloid ...
10
Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation
... anti-amyloid β (anti-A β ) antibody, amyloid β (A β ) protein, and interleukin 8 (IL-8) in cerebrospinal fluid (CSF) of a patient with cerebral amyloid angiopathy-related ...
9
Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimer’s disease
... CSF collection, shipping, aliquoting, storage and analysis took place according to ADNI standard operating proce- dures (SOPs) [29]. It is noteworthy that some early CSF samples were mistakenly collected into ...
10
Glial activation and inflammation along the Alzheimer’s disease continuum
... (A+T−N+, 1 SCD sub- ject, 10 MCI subjects, and 19 AD dementia, and A+T+N +, 7 SCD subjects, 16 MCI subjects, and 8 AD demen- ...panying amyloid pathology (A+) without more extensive inflammatory activation, ...
13
High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer’s disease
... reflecting amyloid accumulation in the brain is a very early event, which is stable from the presymptomatic stage onward ...of amyloid plaques at autopsy is poorly cor- related with clinical status, whereas ...
10
Unbiased estimates of cerebrospinal fluid β-amyloid 1–42 cutoffs in a large memory clinic population
... = 1), normal pressure hydroceph- alus (n = 3), CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoence- phalopathy; n = 1), Creutzfeldt-Jakob disease (n = 3), tauopathy (n ...
8
Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer’s disease in a memory clinic cohort
... Cross-sectional differences among diagnostic categories were assessed using analysis of variance (ANOVA), ad- justed for sex and age, with post-hoc Bonferroni cor- rections, or the Fisher exact test when applicable. For ...
9
<p>CSF VEGF Was Positively Associated with Neurogranin Independent of β-Amyloid Pathology</p>
... We included individuals who had baseline CSF VEGF and NG samples. In this study, there were 83 individuals with NC, 143 individuals with MCI and 65 patients with mild AD dementia. Individuals with NC had a mini- mental ...
8
Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors
... for 1 h at room temperature with alkaline phosphatase-conjugated sec- ondary antibody, and developed using the Western- Light™ Chemiluminescent Detection System (Applied Biosystem Inc) and exposure to x-ray ...
12
Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... interact with APP and regulate its trafficking and process- ing. In this review, we have discussed several possible mechanisms by which APP trafficking and processing are regulated by LRP, LRP1B, SorLA/LR11 and ApoER2 ...
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