and benzimidazoles
Antioxidant and Antimicrobial Activity of Some 2-Phenyl-1H-indoles and Benzimidazoles
... The RSA was scanned using DPPH as substrate. This assay is based on the stabilization of radical reactant. The presence of electron donating substituent increase the stabilization of radical hence making the reactant a ...
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Kaolin-SO3H nanoparticles: A new efficient and reusable catalyst for synthesis of 2-substituted benzimidazoles at room temperature
... In this paper, Kaolin-SO 3 H nanoparticles were prepared and characterized with FT-IR, XRD, FESEM, TEM, XRF, EDS, BET and TGA. We have been able to introduce a new efficient and environmentally friendly pathway for one ...
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SYNTHESIS OF α -AMINOACID FUNCTIONALISED NOVEL FLUORO QUINOLONES AS ANTI-BACTERIAL AGENTS, POLYCYCLIC BENZIMIDAZOLES & DEVELOPMENT OF NEW METHODOLOGIES
... A number of trifluoromethyl substituted heterocyclic compounds such as Mefloquine, Fluoxetine, Flutamide etc., as Pharmaceuticals, several fungicides, herbicides, pesticides as agrochemicals are available as commercial ...
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In-situ Fe electro-oxidation to Improve the Synthesis of Mono and Disubstituted Benzimidazoles
... It is common to find catalytic steps in the synthetic path, since the main reaction depends on the electron transfer to oxidize C-H bonds. Catalysts supported on inorganic substrates have received increasing attention ...
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EXPERIMENTAL EVALUATION OF TITRATIONS OF BENZIMIDAZOLES AND METAL BENZIMIDAZOLES IN NON-AQUEOUS SOLVENTS
... All benzimidazoles have been titrated against perchloric acid prepared in dioxan. Perchloric acid has been standardized with potassium hydrogen phthalate just as anhydrous sodium carbonate broke down in chilly ...
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Synthesis of some new 1,4 dihydropyrimido[1,2 a]benzimidazoles and evaluation of their biological activity
... A mixture of the 2-amino benzimidazole (0.01mol), N-(4-methylthiazol-2-yl)-3-oxobutanamide (0.01mol) and an appropriate aromatic aldehyde (0.01mol) was refluxed in 10 ml of DMF for 30 min. After cooling, methanol (~15 ...
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Synthesis of some new substituted fluoro benzimidazoles and their antimicrobial screening
... comparative assessment of its 1 H-NMR and 19 F-decoupled 1 H-NMR. Synthesis of the appropriate substituted-2- mercapto benzimidazoles 3b-j is depicted in scheme-1. Nucleophilic displacement of aryl chloride in ...
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Green and High Efficient Synthesis of 2 Aryl Benzimidazoles: Reaction of Arylidene Malononitrile and 1,2 Phenylenediamine Derivatives in Water or Solvent Free Conditions
... of benzimidazoles, there have been growing interests in the development of efficient, fast, simple and environment friendly synthetic methods for the preparation of these ...2-substituted benzimidazoles: ...
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Montmorillonite K-10 Supported La(OTf)3: An Efficient Catalyst for the Synthesis of 1,2-Disubstituted Benzimidazoles
... The 1,2-disubstituted benzimidazole scaffold is identified as a potential medicinal agents that efficiently works for therapeutic applications like anticancer, 1 antioxidant, 2 anti- inflammatory, 3 antiviral, 4 obesity, ...
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An Antibacterial, Antifungal and Anthelmintic Evaluations of Some Synthesized Chalcone Derived Benzimidazoles
... compounds 6f and 6j exhibited higher potency than other tested benzimidazoles chalcone while the compounds 6b and 6e were registered less activity. The structure activity relationship studies revealed that polar ...
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Synthesis, characterization and in vivo biological evaluation of novel benzimidazoles as potential anticancer agents
... synthesized benzimidazoles on HeLa cells using MTT ...Thus, benzimidazoles with short chain alkyl groups (8a-c) are less effective than one with higher alkyl group ...hand, benzimidazoles with benzyl ...
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Anthelmintic Resistance in Gastrointestinal Parasites of Small Ruminants with Special Reference to Benzimidazoles- a Review
... Anthelmintic resistance (AR)ingastrointestinal (GI)nematodesof small ruminants especially sheep and goats is an emerging problem across the globe as anoutcome of the over usage of the currently available anthelmintics, ...
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SYNTHESIS, ANTI BACTERIAL, AND ANTI FUNGAL ACTIVITIES OF SOME NOVEL N SUBSTITUTED 2-(4-STYRYLPHENYL)-1H-BENZIMIDAZOLES
... novel benzimidazoles; initially we have carried out the condensation of o-phenylenediamine (OPDA) (1) with 4-bromophenoxy acetic acid (2) in 4N HCl at reflux temperature for 6 ...
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AN EFFICIENT ONE-POT SYNTHESIS OF BENZIMIDAZOLES USING MAGNETICALLY RECOVERABLE CATALYST CHROMIUM DOPED NICKEL COPPER ZINC SPINEL FERRITE
... To evaluate the generality of this approach, various aromatic aldehydes were reacted with o-phenylenediamine (1) under optimized conditions to obtain substituted benzimidazoles (3a-e) (Scheme 1). As shown in Table ...
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A One-Pot Synthesis of 1,4-dihydropyrimido[1,2-a] benzimidazoles and their Antimicrobial Activity
... Recognizing these facts, we have synthesised new series of 1,4-dihydropyrimido[1,2-a]benzimidazoles containing an acetoacetamide fragment.The reaction of various aldehydes with 2-aminobenimidazole and INT-I trace ...
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O : An Efficient Catalyst for Synthesis of Benzimidazoles and Quinoxalines
... 2. Migawa, M., Girardet, J., Walker, J., Koszalka, G., Chamberlain, S., Drach, J., Townsend, L., Design, synthesis, and antiviral activity of alpha-nucleosides: D- and L-isomers of lyxofuranosyl- and ...
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THEORITICAL ASPECTS OF VARIOUS METHODS FOR SYNTHESIS OF BENZIMIDAZOLES
... The mechanistic pathway for the formation of benzimidazoles by the reaction of with natural acids has just been considered. Further, the job of hydrochloric corrosive in the reaction has likewise been ...
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Recent advances in the use of benzimidazoles as corrosion inhibitors
... the benzimidazoles as inhibitors was determined by electrochemical impedance spectroscopy ...of benzimidazoles on the metal surface, which pre- vents reactions at the metal-solution ...the ...
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Mannich Bases of 2-Substituted Benzimidazoles - A Review
... of benzimidazoles possess many pharmacological properties such as anti-oxidant, anti-inflammatory, anticancer, antiviral, anthelmintic and play an important role in medical ...
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SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF SOME 2-SUBSTITUTED BENZIMIDAZOLES
... In conclusion, our study revealed the antimicrobial properties of 2-substituted benzimidazoles. Although the results of in vitro studies were encouraging, further in vivo studies has to be performed, to establish ...
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