and indoxyl sulfate
Triggering of suicidal erythrocyte death by uremic toxin indoxyl sulfate
... observed indoxyl sulfate induced cell membrane scrambling was similarly due to increased cytosolic Ca 2+ ...The indoxyl sulfate concentrations required to trigger phosphatidylserine exposure ...
7
Limited Effect of Intravenously Administered Indoxyl Sulfate, a Uremic Toxin, on the Hepatic Transport of Pravastatin in Normal Rats
... It is generally understood that under seriously impaired renal function a variety of uremic toxins accumulate in the body at greater plasma levels, with indoxyl sulfate (IS) typical of such uremic toxins ...
9
Role of anuria in the relationship between indoxyl sulfate and anemia in peritoneal dialysis patients
... is, indoxyl sulfate; Kt/V, urea amount cleared from plasma divided by distribution volume; nCcr K, normalized renal creatinine clearance; nCcr P, normalized peritoneal creatinine clearance; nPCR, normalized ...
7
Serum indoxyl sulfate is associated with mortality in hospital-acquired acute kidney injury: a prospective cohort study
... IS: Indoxyl sulfate; KDIGO: Kidney Disease: Improving Global Outcomes; MDRD: Modification of diet in renal disease; OATs: Organic anion transporters; RBC: Red blood cell; RRT: Renal replacement therapy; ...
11
Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters
... Abstract: Indoxyl sulfate (IS), a putative low-molecular weight uremic toxin, is excreted in the urine under normal kidney function, but is retained in the circulation and tissues during renal dysfunction ...
10
Indole 3-acetic acid, indoxyl sulfate and paracresyl-sulfate do not influence anemia parameters in hemodialysis patients
... The role of indolic toxins or paracresyl-sulfate (PCS) in anemia has recently been proposed. Indoxyl sulfate (IS) and indole-3-acetic acid (IAA) are protein bound in- dolic uremic toxins derived from ...
9
Effect of astragaloside IV on indoxyl sulfate-induced kidney injury in mice via attenuation of oxidative stress
... Background: Astragalus membranaceus, a traditional Chinese medicine (TCM), has been widely used in the treatment of chronic kidney disease (CKD) in China. Astragaloside IV is one of the major compounds of Astragalus ...
9
Changes in serum indoxyl sulfate levels after acute myocardial infarction and the correlation with kidney injury: an observational study
... IS: Indoxyl sulfate; KIM-1: Kidney injury molecule-1; L-FABP: Liver-type fatty acid-binding protein; LVEF: Left ventricular ejection fraction; MI: Myocardial infarction; NGAL: Neutrophil ...
6
Enzymatic degradation of urinary indoxyl sulfate by Providencia stuartii and Klebsiella pneumoniae causes the purple urine bag syndrome
... We conclude that PUBS results from the action by a bacterial enzyme a phosphatase with minor sulfatase activity, pI 6.4 on the IS in the urine of elderly catheterized patients with high [r] ...
5
Intestinal microbiota in pediatric patients with end stage renal disease: a Midwest Pediatric Nephrology Consortium study
... p-cresyl sulfate and indoxyl sulfate seem to cor- relate with loss of residual renal function ...p-cresyl sulfate and indoxyl sulfate are excreted by renal tubular secretion via ...
11
Regulation of Hepatic Drug Metabolizing Enzymes in Chronic Kidney Disease
... P-cresyl sulfate, p-cresyl glucuronide, indoxyl sulfate, hippuric acid and phenyl sulfate are known gut-derived uremic toxins (Meyer and Hostetter, ...p-cresyl sulfate, indoxyl ...
236
Emodin via colonic irrigation modulates gut microbiota and reduces uremic toxins in rats with chronic kidney disease
... Gut microbiota plays a dual role in chronic kidney disease (CKD) and is closely linked to production of uremic toxins. Strategies of reducing uremic toxins by targeting gut microbiota are emerging. It is known that ...
11
Indoxyl Sulfate Enhance the Hypermethylation of Klotho and Promote the Process of Vascular Calcification in Chronic Kidney Disease
... unclear. Indoxyl sulfate (IS) can reduce renal Klotho expression through CpG hypermethylation of the Klotho gene, suggesting that epigenetic modification of Klotho gene may be an important mechanism of ...
11
Purple urine bag syndrome in benign prostatic hyperplasia patient
... indoxyl sulfate. Urinary tract infection causes bac- teria to produce indoxyl sulfatase, depending on urine pH and oxygen concentration which degrades indoxyl sulfate to indigo (high ...
5
Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease
... IS: Indoxyl sulfate; MCP-1: Monocyte chemoattractant protein-1; NF-kB: Nuclear factor kappa B; PAI-1: Plasminogen activator inhibitor 1; PAP: Plasmin-antiplasmin complex; PCS: p-cresol sulfate; ROS: ...
12
Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy
... acid, indoxyl sulfate, and 4-cresol, produced by numerous kinds of microbiota would facilitate the quick, com- prehensive evaluation of microbiota status without deep sequencing of microbiota 16s ...
19
Protein-bound solute removal during extended multipass versus standard hemodialysis
... C: Concentration; ER: Extraction ratio; HA: Hippuric acid; HD: Hemodialysis; HPLC: High performance liquid chromatography; IAA: Indole acetic acid; IS: Indoxyl sulfate; MPHD: Multipass hemodialysis; N.S.: ...
8
Indoxyl sulfate promotes apoptosis in cultured osteoblast cells
... Background: Indoxyl sulfate (IS), an organic anion uremic toxin, promotes the progression of renal dysfunction. Some studies have suggested that IS inhibits osteoclast differentiation and suppresses ...
9
Uricosuric agents in uremic sera Identification of indoxyl sulfata and hippuric acid
... sera. Indoxyl sulfate, which accumulates to very high concentrations in uremic serum, could not be disclosed in the above-mentioned ...Potassium indoxyl sulfate, when tested in vitro at the ...
12
Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB
... Results: Indoxyl sulfate downregulated Nrf2 expression in HK-2 ...The indoxyl sulfate-induced downregulation of Nrf2 expression was alleviated by an inhibitor of nuclear factor- κ B (NF- κ B) ...
9