Angiogenesis inhibitors
Efficacy and safety of angiogenesis inhibitors in advanced gastric cancer: a systematic review and meta-analysis
... of angiogenesis inhibitor, and the conclusions were ...receiving angiogenesis inhibitors resulted in ...the angiogenesis inhibitors included mainly tar- geted VEGF and its receptor ...
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Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics
... with angiogenesis inhibitors ...that angiogenesis inhibitors enhance the efficacy of certain chemotherapeutics by prolonging contact time of drugs with neoplastic cells [3, ...
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Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors
... kinase inhibitors (RTKIs) (motesanib, pazopanib, sorafenib, sunitinib, vatalanib) with their intratumoral distribution data obtained by matrix-assisted laser desorption ionization mass spectrometry imaging ...to ...
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Angiogenesis inhibitors in the treatment of prostate cancer
... behind angiogenesis has led to the availability of novel drugs that target components of the angiogenesis pathway that are now being utilized in cancer ...esis inhibitors and more conventional ...
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The impact of histological types on the efficacy of angiogenesis inhibitors in the treatment of advanced NSCLC: a meta-analysis of randomized controlled trials
... We searched PubMed (data from January 2000 to October 2014), Embase (data from January 2000 to October 2014), and the Cochrane Library electronic databases. The search criteria included only randomized controlled trials ...
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Overview of advances in vasculogenic mimicry – a potential target for tumor therapy
... Until relatively recently, angiogenesis was considered the sole method of tumor vascularization. Common anti-angiogenesis drugs primarily target endothelial cells, through inducing endothelial cell ...
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Angiogenesis and immune checkpoint inhibitors as therapies for hepatocellular carcinoma: current knowledge and future research directions
... In summary, cabozantinib, regorafenib, and ramuciru- mab have recently become new therapeutic options in patients with advanced HCC previously treated with so- rafenib. Interestingly, the efficacy of these three drugs is ...
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Enhanced therapeutic effect of an antiangiogenesis peptide on lung cancer in vivo combined with salmonella VNP20009 carrying a Sox2 shRNA construct
... AIs, angiogenesis inhibitors; C-caspase 3, cleaved Caspase 3; Cfu, colony forming unit; CSCs, cancer stem cells; H&E, hematoxylin and eosin; IDO1, indoleamine 2, 3-dioxygenase 1; IHC, ...
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Potential Strategies in Treating Tumours
... Cancer therapy exploration is currently being escalated because of the fact that highly effective assistance is yet to be found. Traditional Cytotoxic agents which were used to deal with cancer could hardly discriminate ...
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Original Article Xanthatin, a novel potent inhibitor of VEGFR2 signaling, inhibits angiogenesis and tumor growth in breast cancer cells
... novel angiogenesis inhibitors and in the present study, we examined a small novel mol- ecule, xanthatin as a potent tumor angiogene- sis ...tumor angiogenesis, includ- ing cell migration and tube ...
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Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors
... endogenous inhibitors for pharmacologic ...and angiogenesis assays Gimenez-Gallego and coworkers [14] were able to identify Gentisic acid derivative as possible starting points for the development of ...
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Targeting Angiogenic Pathways in Colorectal Cancer: Complexities, Challenges and Future Directions.
... other angiogenesis-inhibitors (AIs) aflibercept and regorafenib have received regulatory approvals for use in the second and third line mCRC setting respectively [15, ...
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Establishing a Link between Oncogenes and Tumor Angiogenesis
... Oncogenes (and Tumor Suppressor Genes) and Angiogenesis Inhibitors The emphasis in this discussion has been on the idea that oncogenes can contribute to tumor an- giogenesis primaril[r] ...
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Enhancing central noradrenergic function in depression: is there still a place for a new antidepressant?
... Noradrenaline as a specific target for treating depression, as opposed to being part of a multiple target approach, has become more fashionable in recent years with the development of the selective noradrenaline reuptake ...
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Effect of VEGF on the Revascularization of Severed Human Dental Pulps
... in angiogenesis, new vessels are formed from pre-existing ECs. Angiogenesis is an important part of many natural processes, embryonic development, ovulation wound repair and pathological processes, ...
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Endothelial like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor derived angiogenic response
... these inhibitors negatively affected cell viability (Supplementary Figure 3) and on this basis selected 10 µM VEGF inhibitor and 15 µM FGFR inhibitor as concentrations at which anti- angiogenic phenotypes ...
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In-Silico Analysis of 2-(Substituted-2h-Chromen-3-Yl)-5-Aryl-1himidazole Derivatives As An Anti-Angiogenesis Agents In Breast Cancer
... Based on earlier proven pharmacophore analogues of cancer a novel 2 (substituted- 2H-chromen-3-yl)-5-aryl-1H-imidazoles (13–16) were rationally designed. Compounds 13–16 were screened in silico for the inhibition of ...
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The role of αv integrins during angiogenesis: insights into potential mechanisms of action and clinical development
... opmental neovascularization (14). Mice deficient in αv integrins express a dramatic vascular pattern. While most animals die in utero, approximately 20% of αv-deficient mice survive to term but die within hours after ...
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Apln-CreERT:mT/mG reporter mice as a tool for sprouting angiogenesis study
... endothelial sprouting or non-sprouting microvascular growth. In sprouting part, endothelial cells (ECs) can be defined as tip cells, stalk cells, and phalanx cells. Vital pathways, such as Notch and Notch ligands, VEGF ...
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Module-based multiscale simulation of angiogenesis in skeletal muscle
... the angiogenesis models relevant to building a multiscale model of angiogenesis in skeletal muscle using different modeling ...of angiogenesis, ...and angiogenesis [21], and a VEGF ...
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