Angiopoietin 1
Vasculotide, an Angiopoietin 1 mimetic, ameliorates several features of experimental atopic dermatitis like disease
... The decrease in Eotaxin levels in VT-treated animals and the fact that eosinophils express Tie2 and respond to Angiopoietin 1 and 2 [23] guided us to examine the impact of VT on the number of eosinophils ...
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Mast cell–derived angiopoietin 1 plays a critical role in the growth of plasma cell tumors
... ng/ml), and then injected s.c. into the mid-abdominal region of female BALB/c nu/nu 6- to 8-week-old mice (3–5 mice per group). All animal experiments were performed under protocols approved by the National Cancer ...
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Electroacupuncture improves recovery after hemorrhagic brain injury by inducing the expression of angiopoietin 1 and 2 in rats
... using 1 μg/μL oligo(dT) 18 (1 μL), 10 mM dNTP Mix (2 μL), RNase inhibitor (1 μL), and 200 U/μL M-Mulv-Reverse Transcriptase (1 μL) at 70°C for 5 min, 37°C for 5 min, 42°C for 60 min, and 70°C ...
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Angiopoietin-1 enhances neutrophil chemotaxis in vitro and migration in vivo through interaction with CD18 and release of CCL4
... Tie2. Angiopoietin 1 (Ang-1) is agonistic for Tie2, plays a key role in blood vessel maturation and stability and has been shown to possess anti-inflammatory ...engineered ...
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A prospective study of endothelial activation biomarkers, including plasma angiopoietin 1 and angiopoietin 2, in Kenyan women initiating antiretroviral therapy
... if angiopoietin levels are influenced by HIV-1 acquisition and if biomarkers of endothelial activation remain asso- ciated with adverse outcomes among HIV-1-infected pa- tients taking long-term ...
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Plasma levels of angiopoietin 1 and 2 predict cerebral malaria outcome in Central India
... VEGF is an important factor that induces angiogenesis and vasculogenesis. Interactions of angiopoietins with VEGF promote angiogenesis, whereas in the absence of VEGF, ANG-2 causes regression of blood vessels [16]. To ...
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Circulating angiopoietin 1 and angiopoietin 2 in critically ill patients: development and clinical application of two new immunoassays
... Angiopoietin-1 immunoradiometric sandwich assay A polyclonal anti-human Ang-1 affinity-purified goat IgG anti- body (PAB) and a monoclonal anti-human Ang-1 mouse anti- body were obtained from ...
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Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period
... to angiopoietin 1 during the first few postnatal weeks but not thereafter, are analogous to previous findings that inhibition of VEGF or conditional VEGF-gene deletion has much more profound effects on body ...
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Systematic review of the role of angiopoietin 1 and angiopoietin 2 in Plasmodium species infections: biomarkers or therapeutic targets?
... mined angiopoietin levels in Plasmodium falciparum patients to study their ability as biomarkers could distinguish between multiple disease severity states; the more the disease severity states differed, the ...
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Deterioration of alveolar development in mice with both HIF 3α knockout and HIF 2α knockdown
... We analyzed the relative mRNA expression levels of potentially related genes HIF-1α, HIF-2α, VCAM-1, VE- cadherin, angiopoietin 1 (Ang-1) and 2 (Ang-2), Tie-2, vascular endothelial growth ...
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Angiopoietin 1 variant reduces LPS induced microvascular dysfunction in a murine model of sepsis
... valid approach [33,34]. Our results demonstrate a signif- icant reduction during endotoxemia in local angiogenic factors, including Ang-1, Ang-3, endothelin-1 and tissue factor, with no marked changes by ...
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Original Article Serum TIMP-2, NGAL and angiopoietin-2 as biomarkers of coronary artery stenosis
... Coronary angiography may be regarded as the gold standard for diagnosis of coronary artery stenosis (CAS). Although an invasive endovas- cular technique, angiography only rarely results in serious complications such as ...
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Original Article Angiopoietin-1 alleviates LPS-induced inflammatory injury by up-regulation of miR-126 in pancreas cell line HPDE6-C7
... cases. Angiopoietin-1 (Ang-1), a Tie-2 receptor agonist, and microRNA-126 (miR- 126) have been reported to be involved in angiogenesis and anti-inflammatory ...
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Elevated plasma thrombomodulin and angiopoietin 2 predict the development of acute kidney injury in patients with acute myocardial infarction
... One hundred and thirty-two patients who were diag- nosed with AMI from March 2010 to July 2012 were consecutively recruited for this study. Among them, 130 patients had acute ST-elevation myocardial infarction and two ...
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Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis
... Previous studies have used COMP-Ang-1 prophylacti- cally to prevent vascular inflammation and organ dys- function during sepsis [42,43], and our findings demonstrate that MAT.Ang-1 has similar protective ...
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Mechanism of Angiopoietin-1 Upregulation in Kaposi's Sarcoma-Associated Herpesvirus-Infected PEL Cell Lines
... To examine whether ANGPT-1 was really secreted into the culture medium of PEL cells, we measured ANGPT-1 levels in the culture supernatant by ELISA. We could detect secreted ANGPT-1 in ...
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Erratum to: Current perspectives, beliefs and practices concerning delirium in critically ill patients: a multicenter survey among Dutch healthcare professionals
... Introduction Many proposed resuscitative therapies for cardiac arrest and trauma will require the earliest possible intervention and would occur under volatile circumstances, making true informed consent for clinical ...
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Differential regulation of blood flow induced neovascularisation and mural cell recruitment by VEGF and angiopoietin signaling
... To clarify the roles of exogenous VEGF and Ang1 in the process of arteriolargenesis we assessed mural cell recruitment. eNOS and Ang1 were capable of increasing both pericytes and VSMCs indicating that exogenous Ang1 but ...
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The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis
... Additional file 1: Vasculotide induces Tie2 posphorylation in the kidney in vivo. A) Schematic of Vasculotide (VT): Four, eight amino acid peptides (NH2-CHHHRHSF-COOH) are covalently attached via cysteine and ...
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Prognostic value of angiopoietin 2 in non small cell lung cancer patients: a meta analysis
... Angiopoietin-1 (Ang-1) and Ang-2 are ligands for the tyrosine kinase receptor Tie2; they are not only widely expressed on many embryonic tissues, but also expressed on some cancer cells. There is a ...
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