angiopoietin-2
Hypoxic Condition Up Regulates the Expression of Angiopoietin 2 in ADSCs
... Wound healing requires abundant nutrition and blood supply, thus angiogenesis is a vital stage in this process. Angiogenesis involves diverse kinds of immune cells, growth factors, cytokines and inhibitors. ADSCs, ...
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Angiopoietin-2/Tie2 Signaling in the Microenvironment of Chronic Lymphocytic Leukemia (CLL)
... factor angiopoietin 2 (Ang2) has also been described to be upregulated in CLL-plasma and correlated with high microvessel density in bone marrow [14, ...
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Angiopoietin-2 concentration in serum is associated with severe asthma phenotype
... Angiopoietin 2) and vascular endothelial growth factor (VEGF) are considered to play a leading role in angiogen- esis, acting together to form new blood vessels ...
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Angiopoietin 2 exacerbates cardiac hypoxia and inflammation after myocardial infarction
... 11). Angiopoietin-1 (Angpt1) is an ago- nistic ligand of Tie2 that maintains the quiescence and integrity of ECs ...that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is a ...
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Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin 2 levels
... of angiopoietin-2 in endothelial permeability and micro- circulatory perfusion disturbances by targeting plasma angiopoietin-2 with an antibody blocking its effect leading to attenuation of ...
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Prognostic value of angiopoietin 2 in non small cell lung cancer patients: a meta analysis
... identified. Angiopoietin-2 (Ang-2), a cytokine upregulated in tumor endothelial cells and some tumor cells including NSCLC, is a partial agonist and antagonist of angiopoietin-1 ...
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Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis
... Constitutive ablation of the TIE2 receptor impairs vascular integ- rity during a midgestional stage of development (1, 2). Interest- ingly, these observations have been phenocopied by a heart-re- stricted ablation ...
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Angiopoietin 2 as a therapeutic target in hepatocellular carcinoma treatment: current perspectives
... and angiopoietin 2 (Ang2) are expressed on cancer cells, whereas angiopoietin 1 (Ang1) occurs predominantly in support cells of large blood cells as well as stromal, endothelial, and tumor ...of ...
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The Potential Role of Angiopoietin-2 as a Diagnostic Tumor Marker for Hepatocellular Carcinoma
... By studying Ang-2 levels in different groups, the serum Ang-2 had the highest mean levels in HCC group compared to other groups (p≤0.001), also significant difference between HCC versus control and ...
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Serum Angiopoietin-2 as Marker of Plasma Leakage in Dengue Viral Infection
... Mitchels et al reported that serum level of Ang-1 in patient with DHF and DSS at enrollment were lower than at discharged and compared with healthy controls. In contrast, patients with DHF and DSS had higher serum level ...
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Obligatory participation of macrophages in an angiopoietin 2 mediated cell death switch
... Angiopoietin 1 (Ang1; also known as Angpt1 – Mouse Genome Informatics) and angiopoietin 2 (Ang2; also known as Angpt2) are the two best characterized Tie2 ligands. Ang1 (Suri et al., 1996) is an ...
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Biologic significance of angiopoietin 2 expression in human hepatocellular carcinoma
... variant angiopoietin-2 (Ang2) cDNA was obtained from HCC specimens, and the biologic consequences of overexpression on tumor formation and hemorrhage were determined in an animal model ...system. ...
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Opposing actions of angiopoietin 2 on Tie2 signaling and FOXO1 activation
... Tie2 signaling is controlled by the balance of agonistic actions of ANG1 and antagonistic or agonistic actions of ANG2. ANG1 dominates in quiescent blood vessels, but ANG2 plays import- ant roles in inflammation, sepsis, ...
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Original Article Serum TIMP-2, NGAL and angiopoietin-2 as biomarkers of coronary artery stenosis
... er’s exact test for categorical variables. The Jonckheere-Terpstra test was used to com- pare data from more than two groups. Corre- lations between variables were tested using Pearson’s method. Factors predicting ...
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Angiopoietin 2 signaling plays a critical role in neural crest cell migration
... of angiopoietin 2 in neural crest cells showed perturbations in neural crest cell migration To examine the function of Ang2 on neural crest migration, we created an overexpression vector with the ...
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<p>Combined silencing of VEGF-A and angiopoietin-2, a more effective way to inhibit the Ishikawa endometrial cancer cell line</p>
... and angiopoietin-2 (Ang-2) inhibited the biologic mecha- nisms of endometrial cancer more effectively compared to either one alone, in vitro and in ...
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Drug repurposing screen identifies Foxo1-dependent angiopoietin-2 regulation in sepsis
... the angiopoietin-2 ...of angiopoietin-2 expression by liposomal siRNA in vivo improved absolute survival by ...of angiopoietin-2 siRNA and simvastatin showed no additive ...and ...
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Circulating angiopoietin 1 and angiopoietin 2 in critically ill patients: development and clinical application of two new immunoassays
... of angiopoietin-2 (Ang-2) from endothelial Weibel–Palade bodies interferes with constitutive angiopoietin-1 (Ang-1)/Tie2 signaling in endothelial cells, thus leading to vascular barrier ...
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Angiopoietin 2 differentially regulates angiogenesis through TIE2 and integrin signaling
... of angiopoietin research, and its lack represents a major limitation for the rational exploitation of ANG-2 as a therapeutic target of antiangiogenic ...
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Circulating angiopoietin-2 and soluble Tie-2 in type 2 diabetes mellitus: a cross-sectional study
... bin Testing System, D-10, Bio-Rad Laboratories, Inc) and levels of fasting plasma glucose (using the hexokinase method), C-peptide, insulin, lipid profile, liver and renal function parameters were measured in the central ...
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