Angiotensin-Converting Enzyme 1
Role of the angiotensin converting enzyme 1/angiotensin II/angiotensin receptor 1 axis in interstitial collagenase expression in human carotid atheroma
... Measuring signalling pathways using explant culture has the potential to be more representative of what happens in the patient than cell monocultures or animal models. Using fresh human tissue from an active disease ...
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Long-term clinical outcome of patients with severe atherosclerotic renal artery stenosis after percutaneous transluminal renal angioplasty
... ACEi: Angiotensin-converting enzyme inhibitor; ANOVA: Analysis of variance; ARAS: Atherosclerotic renal artery stenosis; ARB: Angiotensin type 1 receptor blocker; ASTRAL: The ...
9
Prevention of diabetes in hypertensive patients: Results and implications from the VALUE trial
... either angiotensin-converting enzyme inhibitors or angiotensin type 1 receptor blockers reduces the incidence of new onset type 2 diabetes in subjects with hypertension and/or ...
8
Angiotensin Converting Enzyme and Angiotensin II Type 1 Receptor Polymorphisms in Patients with Coronary Aneurysms
... by contributing to the inflammatory response [15,16], altering smooth muscle cell migration [17], or inducing matrix metalloproteinases production [18,19]. Aneurys- mal coronary artery disease is characterized by ...
7
Renal and Cardiovascular Effects of Angiotensin-Converting Enzyme Inhibitor Plus Angiotensin II Receptor Antagonist Therapy in Children With Proteinuria
... We studied 10 children (8 male patients and 2 female patients; mean age: 12.3 ⫾ 4.06 years; range: 6 –17 years). The primary renal disease was renal dysplasia for 3 patients, focal glomerulosclerosis for 2, reflux ne- ...
8
The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy
... ACE: Angiotensin-converting enzyme; ADAM: Disintegrin-metalloproteinase; ALDH2: Aldehyde dehydrogenase 2; AngII: Angiotensin II; Ap1: Activator protein-1; ArKO: Aromatase knockout; ...
16
First-line treatment of hypertension: critical appraisal of potential role of aliskiren and hydrochlorothiazide in a fixed combination
... Abstract: Arterial hypertension is one of the major diseases in the Western world. It is an independent cardiovascular risk factor and is associated with increased morbidity and mortality. Several drug classes have been ...
8
Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on the risk of pneumonia and severe exacerbations in patients with COPD
... Data analysis was performed using SAS statistical software version 9.4 (SAS Institute Inc., Cary, NC, USA). The baseline characteristics were presented as descriptive statistics (means, SDs, counts, and percentages). ...
8
Radionuclide Imaging of Neurohormonal System of the Heart
... renin angiotensin system ...blockers, angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers are clinically applied to regulate the neurohormonal levels, but ...
14
Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region
... of Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) and the distribution of Angiotensin II Type 1 Receptor A1166C (AGTR1 A1166C) gene polymorphisms in preeclamptic pregnant ...
5
Comparing the effect of Angiotensin-Converting Enzyme Inhibitors versus Angiotensin Receptor Blockers in heart failure patients with type 2 diabetes mellitus: a systematic review
... of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers in heart fail- ure patients with type 2 diabetes mellitus (Table ...
5
Autoantibodies to angiotensin converting enzyme 2 in patients with connective tissue diseases
... Persistent digital ischemia and clinically evident PAH are intractable and relatively infrequent complications of SLE, SSc, and MCTD - although latent forms of vasculop- athies, including sporadic abnormalities such as ...
8
The association of angiotensin-converting enzyme with biomarkers for Alzheimer’s disease
... quenched fluorogenic peptide substrate (Mca-RPPGFSAFK (Dnp)-OH; ES005) were purchased from R&D Systems and were used to optimize an immunocapture-based fluorogenic assay for measurement of ACE activity in CSF and ...
10
Impact of I/D polymorphism of angiotensin converting enzyme (ACE) gene on myocardial infarction susceptibility among young Moroccan patients
... Our results showed that correlation of clinical risk factors with I/D ACE polymorphism was positive with ‘Obesity’ factor (P = 0.01); no more significant asso- ciation was found with the other risk factors analyzed ...
6
Urinary angiotensinogen level is associated with potassium homeostasis and clinical outcome in patients with polycystic kidney disease: a prospective cohort study
... Polycystic kidney disease (PKD) is a genetic disorder characterized by a progressively increasing number of fluid-filled cysts, distortion of the normal kidney struc- ture, and loss of renal function over a period of ...
12
Memory is preserved in older adults taking AT1 receptor blockers
... ACE: Angiotensin-converting enzyme; ACEI: Angiotensin-converting enzyme inhibitors; ADNI: Alzheimer ’ s Disease Neuroimaging Initiative; ANOVA: Analysis of variance; APOE: ...
14
Decidualisation of human endometrial stromal cells is associated with increased expression and secretion of prorenin
... cleave angiotensin I (Ang I) from renin substrate (angio- tensinogen, AGT), unless it is activated by proteases, low pH [6] or cold ...the enzyme to unfold, exposing the catalytic site [8, ...sin ...
9
Assessment of adverse drug reactions of angiotensin converting enzyme (ace) inhibitors and angiotensin receptor blockers (arbs) among sudanese patients
... A well-documented side effect of ACEIs is a persistent dry cough, the frequency of which ranges from 5–20%. The side- effect usually develops within a few weeks after ACEIs initiation; is not dose-dependent and is more ...
5
Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies
... The fourth study provided an estimate of the population-based incidence of ACEI-AE [18] . This was an analysis of the Mini-Sentinel Program instituted by the FDA to develop a national system for monitoring the safety of ...
9
Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis
... We then tested the hypothesis of potential mNADP- ICDH modification by HNE. Our choice of HNE is based on previous reports indicating that mNADP-ICDH is tar- geted for HNE binding in heart hypertrophy in sponta- neously ...
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