angiotensin II type 1
Increase of angiotensin II type 1 receptor auto-antibodies in Huntington’s disease
... HD subjects were recruited at the Department of Neurology, Ruhr University of Bochum. 132 genetically confirmed HD mutation carriers (72 (54.5%) women and 60 (45.4%) men; mean age 46.9 ± 12.8 years) were screened for ...
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Effects of angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure Role of kinins and angiotensin II type 2 receptors
... Ang II (62), which in turn acts as a growth factor (63, 64), though there is some controversy regarding the existence of intrinsic cardiac renin ...of angiotensin AT 2 receptors in the heart ...
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Effects of an Angiotensin II Type 1 Receptor Blocker on Cardiovascular Calcification
... 1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, ...
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Evidence for the importance of angiotensin II type 1 receptor in ischemia induced angiogenesis
... mice (n = 10) were lightly anesthetized with pentobar- bital (30 mg/kg intramuscularly), and 2 ml of 0.1 vol% oyster glycogen type II (Sigma Chemical Co.) in sterile saline was injected into the peritoneal ...
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Angiotensin Converting Enzyme and Angiotensin II Type 1 Receptor Polymorphisms in Patients with Coronary Aneurysms
... of angiotensin-converting enzyme (ACE) are partly under genetic control [1]; circulating lev- els of ACE are correlated with an insertion (I) / deletion (D) polymorphism [2]: DD genotypes have higher levels ...
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Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth
... In many previous studies, ACE inhibitors were main- ly used to suppress the functions of the RAS as a phar- macological tool; however, ACE inhibitors suppress not only the synthesis of angiotensin II (ATII) ...
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Angiotensin-(1–1) Suppresses Hepatocellular Carcinoma Growth and Angiogenesis via Complex Interactions of Angiotensin II Type 1 Receptor, Angiotensin II Type 2 Receptor and Mas Receptor
... Although the roles of Ang-(1–7) in the cell cycle and cell senescence are unclear, ACE2 was confirmed to upregulate the proportion of cells in the G0/G1 phase in A549 lung cancer cells and induce cell senescence ...
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Prevention of diabetes in hypertensive patients: Results and implications from the VALUE trial
... Figure 1 Schemata of mechanisms underlying the prevention of diabetes development by inhibition of the renin–angiotensin system ...of angiotensin ii produces the following biological effects: ...
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Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro
... Ang II transduces cell signaling upon binding to its re- ceptors, namely angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor ...Ang II ...
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Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region
... of Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) and the distribution of Angiotensin II Type 1 Receptor A1166C (AGTR1 A1166C) gene polymorphisms in preeclamptic pregnant ...
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Dopamine decreases expression of type 1 angiotensin II receptors in renal proximal tubule
... The proximal tubule is also the site of local dopamine pro- duction. Proximal tubules produce dopamine by uptake of L-DOPA ([2]-3-2[3,4-dihydroxyphenyl]-L-alanine) from tu- bular filtrate via a sodium dependent ...
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Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis
... Ang II: angiotensin II; AT1R: Ang II type 1 receptor; AT2R: Ang II type 2 receptor; CCM2: cerebral cavernous malformations 2; EC: endothelial cell; ECM: ...
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Evidence for modulation of pericryptal sheath myofibroblasts in rat descending colon by Transforming Growth Factor β and Angiotensin II.
... caecal crypts by LS diet. Nor are any changes in the amounts of collagen IV, ACE, or AT 1 receptor observed. Despite the presence of AT1 receptors in caecum, no clear increase in AT1 receptors is found with LS ...
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Renal effects of angiotensin II in the newborn period: role of type 1 and type 2 receptors
... Ang II in regulating so- dium transport within the kidney, ranging from natri- uresis to antinatriuresis are mediated through multiple receptors, including AT1Rs and ...Ang II contribution to Na + handling ...
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Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra
... ACE, angiotensin converting enzyme; Ang II, angiotensin II; ANOVA, analysis of variance; AT 1 receptor, Ang II type 1 receptor; Agtr2, gene encoding AT 2 receptor; ...
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Ontogeny of type 1 angiotensin II receptor gene expression in the rat
... developmentally regulated in a tissue-specific manner; (c) during maturation, localization of AT1 mRNA in the kidney shifts from a widespread distribution in the nephrogenic cortex to specific sites in glomeruli, ...
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Angiotensin II upregulates type 1 angiotensin II receptors in renal proximal tubule
... either angiotensin converting enzyme inhibitors or a low salt diet to modulate endogenous Ang II ...Ang II to renal cortical basolateral membranes of captopril-treated rabbits decreased from ...
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LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT1R via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension
... hormone angiotensin II (Ang II), which is converted from the inactive pro-hormone angiotensin I (Ang I) to the active peptide hormone Ang II by angiotensin-converting enzyme ...
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Decreased renal AT1 receptor binding in rats after subtotal nephrectomy: PET study with [18F]FPyKYNE-losartan
... Animals were anesthetized (2 % isoflurane) and kept unconscious throughout the scan using the Inveon DPET camera (Siemens Preclinical Imaging). Rats were set for imaging with the microPET scanner as described pre- ...
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Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis
... A total of 30 female Lewis rats (Charles River, Montreal, QC, Canada), weighing between 220 to 240 g, were stu- died. All animals were conditioned and manipulated according to Canadian Council on Animal Care guidelines. ...
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