Animal Models
Animal Models of Hydrocephalus
... to induce hydrocephalus by implanting a mechanical plug that leads to hydro- cephalus. Some of these substances include cotton or cellophane cylinders im- planted in the cerebral aqueduct of adult dogs [9] [47] [48]; ...
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Animal models of epilepsy: use and limitations
... Chemoconvulsants allow for rapid investigation of epi- leptogenic mechanisms and AED screening at the expense of high mortality of subjects and high variability in the frequency and severity of spontaneous seizures. ...
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Behavioral and cognitive animal models in headache research
... migraine models, as presence of photophobia or photosensitivity can also be measured in light/dark ...of animal studies have investigated cognitive aspects of headache disorders, which remains a relatively ...
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Large animal models for stem cell therapy
... in animal models, human trials so far have shown very modest and variable improvement, indicating that further optimi- zation of techniques is required to improve effi cacy before clinical ...
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Animal models for human disease – reflections from an animal researcher’s perspective
... all animal experimentation is acceptable and not all of animal-model research is valid, that animal models are only one of many routes to gain knowledge in the medical context, and that there ...
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Animal models of retinal vein occlusion
... experimental animal models of RVO are available to study the pathogenesis and to test new diagnostic/prognostic/ therapeutic interventions for this ...
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Animal models of asthma: utility and limitations
... general, animal models have contributed to the current understanding of how the immune system interacts with the functional respiratory system and pulmonary pathophysiol- ...and animal species or ...
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ANIMAL MODELS FOR HUNTINGTONS DISEASES: A REVIEW
... using animal models of to study the Huntington’s disease (HD) disease pathogenesis, to elucidate areas of the brain involved in structural and functional decline, and to evaluate potential therapeutic ...
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HYPERTENSION- ANIMAL MODELS AND PHYTOMEDICINES: A REVIEW
... various animal models used to evaluate antihypertensive activity along with method of induction of hypertension and research progress of some of the herbal drugs that have been used in alternative system ...
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Animal models of contraception: utility and limitations
... delivery is less impacted by heterogeneity of skin morphol- ogy than transdermal formulations; however, as with oral drug delivery, it is subject to species differences in drug distribution and metabolism. A ...
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Animal models of depression and their criteria of validation
... various animal models are being used for studying the disease at the physiological and molecular ...levels. Animal model is a living, non-human animals used during the research and in the examination ...
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The aging bladder insights from animal models
... rodent models revealed complex and interdependent changes that varied with species, strain and ...in animal models, a mixture of “detrusor overactivity and underactivity”-like bladder behavior can be ...
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ROLE OF ANIMAL MODELS IN PERIODONTAL RESEARCH A REVIEW
... These animal models are used to study the periodontal disease to design a better treatment and also to check the effectiveness of the treatment on that particular ...
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The Importance of Animal Models in Tuberculosis Vaccine Development
... Several animal models are used in the evaluation of TB vaccines; the advantages and disadvantages of some of them are summarised in Table ...main animal models for the evaluation of new TB ...
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Current animal models of hemophilia: the state of the art
... Researchers identified an inbred WAG/RijY rat strain, des- ignated WAG/RijYcb, which tended to show abnormal hemorrhaging, a prolonged activated partial thromboplas- tin time, and a mutated FVIII gene (proline was ...
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Metabolic effects of Sapindus trifoliatus in animal models
... in animal models also in receptor radioligand binding studies ST exhibited affinity towards 5-HT 2A receptors and dopamine D 2 receptors in the ligand ...
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Animal models of systemic sclerosis: their utility and limitations
... developed animal models replicating various features of systemic sclerosis have provided insights into the vasculopathy, the role of proteins regulating fibrosis, and the role of the innate immune system in ...
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UTILITIES AND LIMITATIONS OF CURRENT ANIMAL MODELS OF DEPRESSION
... As the name implies, the olfactory bulbs are removed and the rats exposed to stressful situations. This experiment usually has a test and a controlled group. The olfactory system in rats is part of the limbic region ...
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Animal models of rheumatoid arthritis: How informative are they?
... MHC class II molecules present antigens to CD4+ T cells and these cells are present in the synovium of inflamed joints in both humans and animals (Alzabin and Williams, 2011; Todd et al., 1988). The requirement for CD4+ ...
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Animal Models for Salmonellosis: Applications in Vaccine Research
... particularly animal models. Many different animal models exist for vari- ous Salmonella serovars, from whole-animal models to smaller models, such as those recently ...
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