Ankyrin repeat domain 1
The enigmatic role of the ankyrin repeat domain 1 gene in heart development and disease
... the ankyrin repeat domain 1 (ANKRD1) factor (also known as CARP) plays a critical role in transcriptional regulation, myofibrillar assembly and stretch sensing during heart development and ...
12
Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV 1 Gag polyprotein
... of ankyrin-derived repeat proteins consists of a common structural framework made of a the- oretically unlimited number of helix-turn-helix repeat motifs or modules, arranged in a parallel ...of ...
27
Identification of a novel sequence motif recognised by the ankyrin-repeat domain of zDHHC17/13 S-acyl-transferases
... Identification of zDHHC17-interacting Proteins Having a ⌿ XXQP Motif—To identify zDHHC17/13-interacting pro- teins that are highly likely to interact with these zDHHCs via a ⌿ XXQP motif, we searched for this motif in ...
13
Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens group
... Reverse transcription (RT) PCR analysis was performed using the Qiagen Onestep RT-PCR kit (Hilden, Germany). RNase-free water, Onestep RT-PCR buffer (1×), 400 µM dNTPs and Onestep RT-PCR enzyme mix were combined ...
9
Ankyrin repeat and Single KH domain 1 (ANKHD1) drives renal cancer cell proliferation via binding to and altering a subset of miRNAs
... Given the significant alterations in miRNA levels mediated by ANKHD1, we hypothesized that ANKHD1 may exert its pro-proliferative effects via regulating one or more of the miRNAs identified above. Firstly, to test ...
23
Long non-coding RNAs: implications in targeted diagnoses, prognosis, and improved therapeutic strategies in human non- and triple-negative breast cancer
... ANKRD30A: Ankyrin repeat domain 30A; ARA- lncRNA: Adriamycin resistance associated; ARF6: ADP-ribosylation factor 6; BC: Breast cancer; BCAR4: Breast cancer antiestrogen resistance 4; BLK: B ...
15
Role of distinct surfaces of the G9a ankyrin repeat domain in histone and DNA methylation during embryonic stem cell self-renewal and differentiation
... a 1:1 ratio in the TT2 cell line while cell lines constructed for the purpose of this study express solely the G9a long isoform (Figure 1B upper panel: 2 bands in TT2 lane in contrast to 1 band for ...
12
Ankyrin Repeat Proteins of Orf Virus Influence the Cellular Hypoxia Response Pathway
... ABSTRACT Hypoxia-inducible factor (HIF) is a transcriptional activator with a central role in regulating cellular responses to hypoxia. It is also emerging as a major target for viral manipulation of the cellular ...
16
The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review
... Protamine 1 [44]. Human LEM-domain proteins are a heterogeneous family of mainly nuclear proteins that share a conserved amino acid domain, the LEM-domain, that is a binding site for BAF ...
7
Peptide array–based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase
... Figure 3. Validation of predicted zDABM sequences.A peptide array was constructed comprising a total of 109 12-mer peptides, which correspond to 107 human sequences, and two artificial sequences: one expected to bind ...
13
Clinical significance of Ankyrin repeat domain 12 expression in colorectal cancer
... Colorectal cancer (CRC) is one of the leading causes of cancer mortality in the world. An estimated 143,460 new cases of CRC occurred in 2012 and 51,690 people have died from CRC during the same year [1]. In ...
5
The Rickettsial Ankyrin Repeat Protein 2 Is a Type IV Secreted Effector That Associates with the Endoplasmic Reticulum
... the ankyrin repeat domain (ΔAnk), no cytosolic structures were observed and the plaque phenotype remained ...three ankyrin repeats compared with 10 in SS-RARP-2, is secreted FIG 9 The ...
15
Novel mutations highlight the key role of the ankyrin repeat domain in TRPV4-mediated neuropathy
... Immunoblot analyses. HEK293T cells were lysed 24 hours after transfection in radioimmunoprecipitation assay buffer (Sigma- Aldrich) supplemented with protease inhibitors (Sigma-Aldrich) and sonicated. Protein lysates ...
10
Towards the clinical implementation of pharmacogenetics in bipolar disorder
... ANKK1: ankyrin repeat and kinase domain containing 1; BD: bipolar disorder; BDNF: brain-derived neurotrophic factor; bp: base pair; CBZ: carbamazepine; CREB: cyclic AMP response element; ...
15
An association study of Taq1A ANKK1 and C957T and − 141C DRD2 polymorphisms in adults with internet gaming disorder: a pilot study
... This pilot study was designed to investigate the association of the Taq1A polymorphism of the ankyrin repeat and kinase domain containing 1 ( ANKK1 ) gene and C957T and − 141C of[r] ...
8
Atypical IκB proteins – nuclear modulators of NF-κB signaling
... A recent investigation addressed the function of IκBζ in NK cells. It was shown that IκBζ is induced and recruited to proximal promoter regions of the ifng gene upon IL-12 or IL-18 stimulation [70]. As a result of im- ...
11
Eight unique basal bodies in the multi-flagellated diplomonad Giardia lamblia
... The swimming form of Giardia, or the “trophozoite,” has eight flagella that retain the canonical “9 + 2” struc- ture of a motile flagellum [12]. Each flagellum also has radial spokes, dynein arms, and outer doublet and ...
10
Protein binders and their applications in developmental biology
... degradation-inducing domain (see below), a powerful method was developed to ablate inhibitory synapses in vivo and study the resulting developmental or behavioural alterations (Gross et ...
13
Investigating the role of ankyrin repeat and SOCS box protein 4 (ASB4) during vascular development
... We identify that ASB4 is only the fourth in a limited list of known FIH hydroxylation substrates, and thus provide a mechanism for ASB4 modulation of cell phenotypes in an oxygen-dependent manner. FIH-mediated ...
98
Spectrin and phospholipids — the current picture of their fascinating interplay
... th repeat of β-spectrin was shown to increase upon interacting with membranes or detergents ...th repeat partially separate from each ...the ankyrin-binding domain suggest that the W1771 ...
22