Anterograde axonal transport
Dual Role of Herpes Simplex Virus 1 pUS9 in Virus Anterograde Axonal Transport and Final Assembly in Growth Cones in Distal Axons
... the anterograde transport and assembly of HSV-1 in the distal axon of human and rat dorsal root ganglion (DRG) neurons using US9 deletion (US9 ⴚ ), repair (US9R), and wild-type (strain F, 17, and KOS) ...
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Glycoproteins gE and gI Are Required for Efficient KIF1A-Dependent Anterograde Axonal Transport of Alphaherpesvirus Particles in Neurons
... and anterograde spread in neurons, but it is not clear if these two phenotypes reflect common or distinct mecha- ...the transport vesicle membrane to recruit KIF1A for axonal ...the transport ...
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LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains
... fundamental transport processes within axons includ- ing those driven by kinesin-1 and myosin ...both axonal transport and neuronal signal- ing functions which are all perturbed in ...facilitates ...
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Anterograde Transport of Herpes Simplex Virus Proteins in Axons of Peripheral Human Fetal Neurons: an Immunoelectron Microscopy Study
... to axonal termini it is transported ret- rogradely along the axon to the neuronal cell body, where it becomes ...(anterograde axonal transport) ...of axonal transport are not ...
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Axonal degeneration in paraplegin deficient mice is associated with abnormal mitochondria and impairment of axonal transport
... of anterograde axonal transport. Axonal transport is an energy- dependent process that is especially crucial to the long axons affected in HSP, which transport molecules and ...
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Ultrastructural Analysis of Virion Formation and Anterograde Intraaxonal Transport of the Alphaherpesvirus Pseudorabies Virus in Primary Neurons
... Most members of the subfamily Alphaherpesvirinae within the family Herpesviridae in the order Herpesvirales (8) are char- acterized by a pronounced neurotropism. They include the type member of the genus Simplexvirus, ...
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Anterograde Spread of Herpes Simplex Virus Type 1 Requires Glycoprotein E and Glycoprotein I but Not Us9
... the anterograde axonal transport or anterograde neuronal spread of the alphaherpesviruses HSV-1, PRV, BHV-1, and BHV-5 (2, 5, 7, 9, 11, 13, 16, 26, 29–31, 41, 46, 51, ...HSV-1 ...
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Zika Virus Infects Trabecular Meshwork and Causes Trabeculitis and Glaucomatous Pathology in Mouse Eyes
... in glaucoma impairs axonal transport (46, 48, 67, 68). Although ZIKV has been shown to infect the optic nerve head in neonate pups (6), our study is the first to demonstrate the disruption of ...
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Anterograde, transneuronal transport of herpes simplex virus type 1 strain H129 in the murine visual system.
... and anterograde axonal transport as it establishes latency and later intermittently ...retrograde transport within the central nervous system (CNS), ...via anterograde, transneuronal ...
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Anterograde Glycoprotein-Dependent Transport of Newly Generated Rabies Virus in Dorsal Root Ganglion Neurons
... supported anterograde axonal RABV transport in DRG and other peripheral neurons (26, 27, ...after anterograde transport through DRG neurons, strongly sup- porting the hypothesis that ...
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Two Modes of Herpesvirus Trafficking in Neurons: Membrane Acquisition Directs Motion
... after anterograde axonal transport, all assays employed static imaging of fixed ...intracellular transport, from static images can lead to dissimilar ...of anterograde axonal ...
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Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria.
... disrupts anterograde axonal transport of ...mitochondrial transport involved reductions in the fre- quency, velocity and persistence of anterograde mitochondrial ...movement. ...
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The Us9 Gene of Bovine Herpesvirus 1 (BHV-1) Effectively Complements a Us9-Null Strain of BHV-5 for Anterograde Transport, Neurovirulence, and Neuroinvasiveness in a Rabbit Model
... for anterograde axonal transport (7, 8, 13, 19, 23, ...Us9-mediated anterograde spread in vivo, and several serine residues within the acidic cluster were major sites for Us9 phosphorylation ...
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Ladwig, Anne (2017): Morphologische Analyse der distalen Auswirkungen des axonalen Transportdefizits in einem Tiermodell der Multiplen Sklerose. Dissertation, LMU München: Medizinische Fakultät
... to apply in the living animal, this model constitutes a unique opportunity to study in vivo mitochondrial dynamics and their pathological alterations. The CFP gene is fused with the mitochondrial targeting sequence of ...
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In Vitro Analysis of Transneuronal Spread of an Alphaherpesvirus Infection in Peripheral Nervous System Neurons
... We made several key observations on transneuronal spread using the isolator chamber system. First, we have established that the system is leakproof and that in vitro transneuronal spread depends entirely on axonal ...
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Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43
... autonomic circuitry. Indeed, the trigeminal nerve possesses nociceptive neurons, which are present in the respiratory epithelium of the nasal cavity (65) and can theoretically be infected by HCoV OC43 to invade the CNS, ...
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Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases
... undergoing anterograde transport correspond to diagonal lines with positive slope in the kymograph (see Methods for additional ...the transport velocities of Golgi-derived vesicles (based on 772 ...
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Familial amyotrophic lateral sclerosis linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content
... Figure 4. Mutant SOD1 causes depletion of mitochondria from axons. The distribution of mitochondria was analyzed in motoneurons from ntg and SOD1 G93A transgenic mice, and in rat cortical neurons transfected with ...
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Axonal transport defects are a common phenotype in Drosophila models of ALS
... A prime motivation for this study was to correlate disruptions in axonal transport to decline in motor neuron function; the cardinal clinical feature of ALS. Thus, flies were examined for their neuro- ...
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Decreased axonal transport of structural proteins in streptozotocin diabetic rats
... various axonal transport rates in sciatic nerve of streptozotocin diabetic rats 3 h and 10,25, and 50 d after the injection of tritiated proline into the fifth lumbar dorsal root ...slow transport ...
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