Anthrax Vaccine Adsorbed
Comprehensive Analysis and Selection of Anthrax Vaccine Adsorbed Immune Correlates of Protection in Rhesus Macaques
... inhalation anthrax in a rhesus macaque (Macaca mu- latta) model were ...of anthrax vaccine adsorbed (AVA) (BioThrax) at 0, 1, and 6 ...of vaccine dilutions. Together with the ...
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Vaccination of Rhesus Macaques with the Anthrax Vaccine Adsorbed Vaccine Produces a Serum Antibody Response That Effectively Neutralizes Receptor-Bound Protective Antigen In Vitro
... Anthrax toxin (ATx) is composed of the binary exotoxins lethal toxin (LTx) and edema toxin (ETx). They have separate effector proteins (edema factor and lethal factor) but have the same binding protein, protective ...
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Bacillus anthracis Virulence in Guinea Pigs Vaccinated with Anthrax Vaccine Adsorbed Is Linked to Plasmid Quantities and Clonality
... Bacillus anthracis is a bacterial pathogen of great importance, both historically and in the present. This study presents data collected from several investigations and indicates that B. anthracis virulence is associated ...
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Humoral and Cell-Mediated Immune Responses to Alternate Booster Schedules of Anthrax Vaccine Adsorbed in Humans
... Protective antigen (PA)-specific antibody and cell-mediated immune (CMI) responses to annual and alternate booster schedules of anthrax vaccine adsorbed (AVA; BioThrax) were characterized in humans ...
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Unique Inflammatory Mediators and Specific IgE Levels Distinguish Local from Systemic Reactions after Anthrax Vaccine Adsorbed Vaccination
... that anthrax vaccine adsorbed (AVA) has an adverse event (AE) pro- file similar to those of other adult vaccines, 30 to 70% of queried AVA vaccinees report ...a vaccine-specific IgE response ...
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A Three-Dose Intramuscular Injection Schedule of Anthrax Vaccine Adsorbed Generates Sustained Humoral and Cellular Immune Responses to Protective Antigen and Provides Long-Term Protection against Inhalation Anthrax in Rhesus Macaques
... A subset of study NHPs was analyzed at days 3, 5, 6, 7, 10, and 14 after completing the priming series at 6 months. Groups 1 to 5 had blood draws at postpriming (PP) days 3, 5, 7, and 14; group 9 had blood draws at PP ...
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Evaluation of Immunogenicity and Efficacy of Anthrax Vaccine Adsorbed for Postexposure Prophylaxis
... Inhalation anthrax is con- sidered highly lethal, with the fatality rate approaching 100% when untreated ...produce anthrax lethal toxin (LT), and PA and EF combine to produce edema toxin ...
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Rapid, Sensitive, and Specific Lateral-Flow Immunochromatographic Device To Measure Anti-Anthrax Protective Antigen Immunoglobulin G in Serum and Whole Blood
... Evidence from animals suggests that anti-anthrax protective antigen (PA) immunoglobulin G (IgG) from vaccination with anthrax vaccine adsorbed (AVA) is protective against Bacillus anthracis ...
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Anthrax Vaccine Precipitated Induces Edema Toxin-Neutralizing, Edema Factor-Specific Antibodies in Human Recipients
... to anthrax disease. Anthrax vaccine precipitated (AVP) contains low but detectable levels of EF and can elicit EF-specific antibodies in human recipi- ents of ...versus anthrax vaccine ...
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Efficacy and Immunogenicity of Single-Dose AdVAV Intranasal Anthrax Vaccine Compared to Anthrax Vaccine Absorbed in an Aerosolized Spore Rabbit Challenge Model
... adenoviral anthrax vaccine, is an E1- and E3-deleted adenoviral expression vector that expresses the ...spores. Anthrax Vaccine Adsorbed (AVA; BioThrax, Emergent Bio- Solutions, ...
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Development of an improved vaccine for anthrax
... and vaccine development for anthrax was heightened by the deliberate contamination of mail with ...human vaccine (anthrax vaccine adsorbed, or AVA) was not available because the ...
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Neutralizing Activity of Vaccine-Induced Antibodies to Two Bacillus anthracis Toxin Components, Lethal Factor and Edema Factor
... Anthrax vaccine adsorbed (AVA; BioThrax), the current FDA-licensed human anthrax vaccine, contains various amounts of the three anthrax toxin components, protective antigen (PA), ...
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An Adenovirus-Vectored Nasal Vaccine Confers Rapid and Sustained Protection against Anthrax in a Single-Dose Regimen
... human anthrax vaccine in the United States is anthrax vaccine adsorbed (AVA; BioThrax), which is pro- duced by adsorbing cell-free filtrates of microaerophilic cultures of the ...
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Gastrointestinal Anthrax: A Case and Review of Literature
... of anthrax infections are cutaneous infections due to easy ...pulmonary anthrax and oral transmission leads to gastrointestinal ...organ anthrax infections is extremely high. Gastrointestinal ...
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Increasing the Potency of an Alhydrogel-Formulated Anthrax Vaccine by Minimizing Antigen-Adjuvant Interactions
... Mouse anthrax challenge assay. The mouse anthrax challenge assay, which emulates the human immunological response to anthrax infection, was used for all release and stability testing of the rPA ...
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Periocular cutaneous anthrax in Jimma Zone, Southwest Ethiopia: a case series
... cutaneous anthrax is necrotizing fasciitis which presents with rapidly progressive severe inflammation initially involving subcutaneous tissues and later the skin and accompanied by tissue necrosis ...
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Recombinant Protective Antigen Anthrax Vaccine Improves Survival when Administered as a Postexposure Prophylaxis Countermeasure with Antibiotic in the New Zealand White Rabbit Model of Inhalation Anthrax
... Animals. Specific-pathogen-free New Zealand White rabbits (NZWRs) weighing between 2.5 and 3.0 kg were purchased from Covance. NZWRs were housed individually in stainless steel cages with food and water avail- able ad ...
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Expression of the protective antigen of bacillus anthracis in attenuated salmonella : a potential oral anthrax vaccine
... directed vaccine effort; with som e diseases the protective antigens have not been identified, or a response to a number o f antigens are required to stimulate protective ...against anthrax is not w ell ...
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IMMUNIZATION WITH COMBINED DIPHTHERIA AND TETANUS TOXOIDS (ALUMINUM HYDROXIDE ADSORBED) CONTAINING H. PERTUSSIS VACCINE
... The diphtheria antitoxin demonstrated is obviously due not only to two injections of the triple mixture containing diphtheria toxoid, but also to the toxin in the Schick test, which was [r] ...
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Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A
... recipients of the IRIV formulation seroconverted (> or = 20 mIU/ml) versus 30 and 44% for those who received the fluid and alum-adsorbed vaccines, respectively (P < 0.001). The geometric mean anti-HAV ...
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