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 IN-VITRO AND IN-VIVO ANTI-ASTHMATIC ACTIVITY OF ETHANOLIC LEAF EXTRACT OF CAESALPINIA PULCHERRIMA

 IN-VITRO AND IN-VIVO ANTI-ASTHMATIC ACTIVITY OF ETHANOLIC LEAF EXTRACT OF CAESALPINIA PULCHERRIMA

Keeping the above in the mind, and to justify the traditional claim, the study was aimed at investigating the anti-asthmatic property of the ethanolic leaf extract of Caesalpinia pulcherrima, by assessing its effect on histamine-induced bronchospasm. Caesalpinia pulcherrima belonging to the family Fabaceae, which grows well in all kinds of soil including sand, clay, loam, acidic or alkaline soils.

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Synthesis, Anticancer, Anti Tumor, Anti Diabetic and Anti Asthmatic Screening of Some Novel Clubbed Tetrazole Moiety Compounds

Synthesis, Anticancer, Anti Tumor, Anti Diabetic and Anti Asthmatic Screening of Some Novel Clubbed Tetrazole Moiety Compounds

Abstract: A series of novel substituted benzimidazole derivatives by the condensation of different diamines with anthranilicacid were synthesized. The subsequent reactions of the benzimidazole derivatives were reacted with different aromatic acid chlorides to get tetrazole moieties. These compounds were screened for their potential anticancer, anti-diabetic, anti tumor and anti asthmatic properties, which exhibited some authentic results towards testing organism invitro and invivo studies.

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Synthesis, Anti Tumor, Anti Diabetic, and Anti  Asthmatic Activitives of Some Novel Benzimidazole Derivatives

Synthesis, Anti Tumor, Anti Diabetic, and Anti Asthmatic Activitives of Some Novel Benzimidazole Derivatives

All the compounds prepared herein were screened for their potential anti-asthmatic activities such as, they were tested against PDE-IV for potential anti-asthmatic effect, and against DPP-IV and PTP1B for potential anti-diabetic effects. Moderate activity was found. The anti-asthmatic activity was carried out using phosphodiesterase IV enzyme (PDE-IV) 22 (Table-4) and the primary screening of the compounds was done at 1 u M concentration using human PDE-IV enzyme, where Rolipram

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EVALUATION OF ANTI-ASTHMATIC ACTIVITY OF ETHANOLIC 
EXTRACT OF SOLANUM XANTHOCARPUM LEAVES

EVALUATION OF ANTI-ASTHMATIC ACTIVITY OF ETHANOLIC EXTRACT OF SOLANUM XANTHOCARPUM LEAVES

Asthma is a chronic disease that affects approximately 300 million people worldwide. Although wide range of drug is available, the relief is mainly symptomatic and short lived. Solanum xanthocarpum Schrad. (Solanaceae), also known as yellow berried nightshade (English), is traditionally used to treat asthma. However, the scientific data on anti-asthmatic and anti-inflammatory actions of this plant has got little attention. An attempt has been made to evaluate anti-asthmatic, anti-inflammatory and mast cell stabilizing activities of ethanolic extract of Solanum xanthocarpum leaves (EESX) using acetylcholine (Ach) and histamine-induced airway constriction in guinea pigs and carrageenan-, dextran-, and histamine-induced paw oedemas, and cotton pellet-induced granuloma tests in rats. EESX showed significant bronchodilator activity on histamine-induced airway constriction and reversed the allergen-induced bronchospasm. Interestingly, EESX protected mast cells from compound 48/80-provoked degranulation and inhibited acute, sub-acute and chronic inflammation in different animal models. The LD 50 of EESX was 2262.7 mg/kg, i.p. The present study for
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IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY STUDY OF SOME SELECTED ANTI-ASTHMATIC AGENTS

IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY STUDY OF SOME SELECTED ANTI-ASTHMATIC AGENTS

Asthma is a disease affecting the airways that carry air to and from lungs. Exposure to various irritants and substances that trigger allergies (allergens) can trigger signs and symptoms of asthma. The prevalence of asthma varies widely in different regions of the world due to distinct genetic, environmental and occupational risk factors. In this research investigation, we study the pharmacokinetic, drug-likeness, bioactivity profile and toxicity profile of some selected anti-asthmatic agents by computational methods. The study provides the information about the pharmacokinetic and toxicity of existing drugs that can be used for design and development of new anti-asthmatic agents with more potency and lesser toxicity.
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Evaluation of Anti-Asthmatic Activity of Anacardium Occidentale L. Leaves

Evaluation of Anti-Asthmatic Activity of Anacardium Occidentale L. Leaves

There are two types of asthma, Atopic and non-atopic. Atopic occurs in children and young adults who have atopic (type-I) hypersensitivity to foreign proteins. Again when the same antigen comes into contact the antibody/antigen reoccurs resulting in release of histamine and other factors increase mucous secretion and muscular contraction that narrows the airways. Attacks become less frequent and less severe with age. Non- atopic occurs in adult life with no childhood history and is associated with chronic inflammation of upper respiratory tract. Eventually impaired lung ventilation leads to hypoxia, pulmonary hypertension and right sided heart failure. Anti asthmatic drugs like corticosteroids, theophylline, salbutamol are widely used in the treatment of asthma but these drugs produce some adverse effects like immune suppression, cardiac problems [4]. Now a day the approach on herbal medicine to reduce the adverse effects has been increased and Anacardium occidentale L. is one of the traditional herbal medicine which claims to have many therapeutically beneficial effects. Anacardium occidentale L. kernel contains proteins, fats, fibres, carbohydrates, minerals etc. Leaves comprise tannins (23%), nontannins (18%), β-sitosterol, ethyl gallate, hyperoside, methyl gallate, leucocyanidin and leucodelphidins [5]. Alcoholic extract of leaves show hypoglycemic activity in albino rats. Tar from bark is used as counterirritant; while the kernel is nutritive, demulcent and emollient. In Peruvian herbal medicine, cashew leaf tea is employed as common diarrheal remedy. Bark tea as common antiseptic, vaginal douche and seeds are used for skin infections. Cashew fruit is used in leprosy, psoriasis and as a blister in warts, corns and ulcers [6]. The bark and leaves are used medicinally in curing toothache, sore gum and as a remedy for scurvy. So, the aim of the study was to give a scientific evaluation of anti-asthmatic property of Anacardium occidentale L. [7].
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Evaluation of Anti-Asthmatic Property of Solanum Xanthocarpum Flower Extracts.

Evaluation of Anti-Asthmatic Property of Solanum Xanthocarpum Flower Extracts.

Kantkari (Solanum Xanthocarpum) is one of the members of the dashmula (ten roots) of the Ayurveda. It is a very spiny diffuse herb up to 1.2 m tall, commonly found throughout India, used in medicine in various forms, such as decoction, electuary, ghrita, etc. A decoction of the root is given with the addition of long pepper and honey, in cough and catarrh, and with rock salt and assafoetida in spasmodic cough. Plant has been investigated for much of responses and as well a pilot study on the clinical efficacy of Solanum xanthocarpum as a dried whole plant shown significant improvement in some respiratory diseases like bronchial asthma. The present study aimed at investigating the anti-asthmatic property of petroleum ether, ethanol (95%), water extract of flowers of Solanum xanthocarpum, obtained by successive extraction on in-vitro and in-vivo animal models. Compared to Pet. Ether and water extract only ethanolic (95%) extract (SXEX) shown promising result as relaxed the histamine precontracted isolated goat tracheal chain (P<0.05). A dose dependent contraction of goat tracheal chain is observed. Treatment with SXEX (100 mg/kg, i.p.) treatment significantly (p< 0.05) reduced milk induced eosinophilia (18.16±0.912) and SXEX (50 mg/kg, i.p.) able to control the milk induced eosinophilia (25.5± 5.71) as compared control group which receives only vehicle and milk (43.2±0.663) in mice (n=5), while mast cells were protected at a dose of (50 &100 mg/kg, i.p) by 74.39% and 78.26 % respectively by SXEX as compared to DSCG shown protection by 83.81%. Also, SXEX decreased capillary permeability by 62% in mice was evident from its effect on optical density of the dye. Phytochemical screening showed presence of phyto sterols, alkaloids, flavonoids and steroids. The result suggest that the SXEX possess antihistaminic, mast cell stabilizing and decreased capillary permeability effect and hence possesses potential role in the treatment of asthma and allergic disorders. .
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 PHARMACOLOGICAL SCREENING OF ANTI-ASTHMATIC ACTIVITY OF ANISOMELES MALABARICA (L).R.BR.EXSIMS

 PHARMACOLOGICAL SCREENING OF ANTI-ASTHMATIC ACTIVITY OF ANISOMELES MALABARICA (L).R.BR.EXSIMS

Objective: In the study the chloroform and methanolic leaves extract of Anisomeles malabarica Linn (Lamiaceae) was investigated for screening of anti histaminic effect by using guinea pig model. Methods: Identified the protective effect against asthmatic activity using different method like both invivo (Histamine induced bronchospasm in conscious guinea pigs) and invitro(Histamine induced contraction on isolated guinea pig ileum preparation) models. Resuts:. Percentage inhibition of histamine in isolated guinea pig ileum preparation show significant inhibition in standard is 52.26% as like that the extract of MEAM also shows significant inhibition of histamine of about 35.20 %. Conculation:The conculed of the present investigation was find out the anti-asthmatic activity of chloroform and methanolic extract of AM by using histamine induced bronchospsam in conscious guinea pig. The preliminary phytochemical study prove the presence of alkaloids, flavonoids, tri-terpenoids,and saponin. The both extract of CEAM and MEAM was possessing good protection against respiratory disease but methanolic extract 200mg/kg have shows highly protective action than the CEAM. Keywords: Anti asthmatic, Anisomeles malabarica, Histamine, chloroform, Methanol, Guinea pig
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Synthesis, anti bacterial, anti asthmatic and anti diabetic activities of novel 3 substituted quinazolin 4 ones using 1 Butyl 3 methyl imidazoliumtetrafluoroborate [BMIM+][BF4 ] as a green, efficient and reusable catalyst undersolvent free conditions

Synthesis, anti bacterial, anti asthmatic and anti diabetic activities of novel 3 substituted quinazolin 4 ones using 1 Butyl 3 methyl imidazoliumtetrafluoroborate [BMIM+][BF4 ] as a green, efficient and reusable catalyst undersolvent free conditions

A convenient, one-pot synthesis of 3-substitutedquinazolinone derivatives by the reaction of anthranalic acid, ortho formates and aryl or alkyl amines in presence of 1-Butyl-3-methylimidazolium tetrafluoroborate [BMIM + ][BF4 - ] as a green, efficient reusable catalyst has been described. The reaction proceeded within few minutes with excellent yields. The simplicity of the experimental procedure as well as the re-usability of the catalyst are the significant advantages of this protocol. All the compounds synthesized were screened for their anti-bacterial, anti-asthmatic and anti-diabetic activities.
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Evaluation of Anti-Asthmatic Potential of Ethyl Acetate Fraction of Pluchea Lanceolata

Evaluation of Anti-Asthmatic Potential of Ethyl Acetate Fraction of Pluchea Lanceolata

Asthma can be characterised by hyper response of trachea bronchial smooth muscles to various stimuli, which results in the narrowing of the air tubules along with increase secretion from mucosal membrane, accompanied by mucosal edema and mucus plugging [8]. Almost 200 million people worldwide suffer from asthma with the mortality rate of 0.2 million per year. In India alone 15 million people suffer from asthma. The cause of bronchial asthma includes food, allergens, season, viral infection, air pollutants, various irritants, genetics etc. The present line of treatment mainly includes like mast cell stabilizers, corticosteroids, anti-cholenergics, methylxanthines and sympathomimetics. But this line of treatment is accompanied by various side effects, therefore plant based drugs are now being considered as an alternative approach to control this disease because it is considered safe and without any side effects. With these objectives in mind the present study is designed to evaluate the antioxidant and anti asthmatic activity of Pluchea lanceolata leaves.
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Design and Evaluation of Niosomes Containing Salbutamol Sulphate Anti-Asthmatic Drug

Design and Evaluation of Niosomes Containing Salbutamol Sulphate Anti-Asthmatic Drug

Niosomes have been used to prolong the circulation of the drugs, to alter the distribution of drugs and they offer a host of other advantages. Niosomes favour selective delivery of drugs and improves the therapeutic efficacy and reduces the severity of side effects. The need for present study is to encapsulate the drug in the niosomes vesicles for effective Respiratory system drug delivery for a prolonged period of time. Salbutamol Sulphate is one of the most effective drug in the treatment of Anti-asthmatic. My objective of this study is to treat Asthmatic with Salbutamol Sulphate niosomes, since it is an short-acting, selective beta2- adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1- adrenergic receptors located in the heart. Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that salbutamol increases cAMP production by activating adenylate cyclase, and the actions of salbutamol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentration leads to a smooth muscle relaxation and bronchodilation. In addition to bronchodilation, salbutamol inhibits the release of bronchoconstricting agents from mast cells, inhibits microvascular leakage, and enhances mucociliary clearance. It has short biological half life of 1-2 hours and requires frequent administration for a prolonged period of time. Since, niosomes prolong the circulation of many drugs and alters the distribution of drugs, I aimed at formulating Salbutamol Sulphate in
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Liposomes prolong the therapeutic effect of anti-asthmatic medication via pulmonary delivery

Liposomes prolong the therapeutic effect of anti-asthmatic medication via pulmonary delivery

Liposomes showed promising properties as a drug delivery system for SBS. Water-soluble SBS could be efficiently encapsulated into liposomes prepared by the VPG method. The optimal EE was achieved by use of isotonic agents. In addition to the sustained release effect of the formulation, unencapsulated SBS in the liposome suspension may pro- vide an immediate bronchodilating effect. In vivo animal studies showed that SBS was released from liposomes to act on the β 2 receptor in the pulmonary tissues leading to the bronchodilating effect. Fluorescence images of DiR SBS liposomes indicated that liposomes were homoge- neously distributed in the lungs and the total decrease of radiation intensity suggested that lipids and DiR itself may be eliminated in time from the respiratory tissues. The pharmacodynamic study of guinea pigs demonstrated a significantly longer anti-asthmatic effect by SBS liposome suspension compared to free SBS solution. In summary, the present study suggests higher therapeutic efficacy for SBS by liposome-mediated pulmonary delivery, as this approach can reduce the frequency of administration by increasing the drug retention time in the lungs and avoid systemic side effects due to accumulating drug after fre- quent administration. Future studies may focus on the modification of liposomes by using polyethylene glycol to enhance the stability of liposomes in vivo and, furthermore, by conjugating with targeting ligands to enrich site-specific therapeutic action.
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Evaluation of Anti-Asthmatic Activity of Glycyrrhiza Glabra

Evaluation of Anti-Asthmatic Activity of Glycyrrhiza Glabra

Asthma is a chronic disease associated with allergic reaction in the body. The allergic reaction is due to the production of histamine secreted by the mast cells of the human body. Glycyrrhiza glabra Linn. is a plant of family Fabaceae. The rhizome, stem and seeds of the plant are used as anti- inflammatory drug in the tribal areas. In this research, the crude extract was obtained from the parts of Glycyrrhiza glabra by the process of cold percolation and Soxhlet method. It’s different fractions were purified by column chromatography and thin layer chromatography. The purified samples were identified by spectral analysis including HNMR, CNMR and Mass spectroscopy. The swiss variety of albino rats were induced asthma by triple antigen. Purified saponin fraction of the extract of Glycyrrhiza glabra was injected to the infected rats. The result obtained shows that the saponin fraction is effective in triple antigen sensitized albino rats as anti-asthmatic agent. The inhibition on mast cell degranulation took place up to 62% at 25 mg/Kg body weight.
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Anti-Asthmatic and Anti-Anaphylactic Activity of Helicanthus Elastica Desr

Anti-Asthmatic and Anti-Anaphylactic Activity of Helicanthus Elastica Desr

Asthma is a complex and multifactorial airway disease. Due to side effects and resistance like limitations, development of new treatments represents a major goal for the researchers. So the purpose of the present study was to evaluate ethyl acetate fraction of Helicanthus elastica (H. elastic) for anti-asthmatic and anti- anaphylactic activity by various animal models. The antiasthmatic activity of H. elastica was studied on the bronchial hyperactivity models like histamine induced bronchospasm in guinea pigs. While for anti-anaphylactic activity was studied by active and passive anaphylaxis in rats. Treatment with H. elastica showed significant protection against histamine aerosol-induced bronchospasm in guinea pigs. H. elastica treatment for 14 days resulted significant mast cells stabilization of actively and passively sensitized rats, also reduction in eosinophil cell count, IgE count and give relief from nasal acoustic symptom. Anti- asthmatic and anti-anaphylactic activity of H. elastica may be due to anti-histaminic property and mast cell membrane stabilizing potential, suppression of IgE antibody production, suppression of eosinophil cell activation respectively.
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Evaluation Alpinia galanga Essential Oil for  Anti Asthmatic Activity in Animal Models

Evaluation Alpinia galanga Essential Oil for  Anti Asthmatic Activity in Animal Models

In histamine induced bronchospasm model, A. galanga showed dose dependent % protection against PCD, which proved that histamine that antihistaminic activity. The present study also suggest that it significantly decrease the airway inflammation induced by ovalbumin hence the present study proved that essential oil bearing antihistaminic, anti-inflammatory effect which has essential to treat asthma. On the basis of the present study it is concluded that the essential oil of A. galanga possess antiasthmatic activity.

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A Pharmacological Evaluation for the Ethanolic Extract of Alpinia Calcarata Rhizome for it’s Anti - Asthmatic, Antioxidant and Anti - Inflammatory Activities

A Pharmacological Evaluation for the Ethanolic Extract of Alpinia Calcarata Rhizome for it’s Anti - Asthmatic, Antioxidant and Anti - Inflammatory Activities

Increased numbers of eosinophils exist in the airways of most, but not all, persons who have asthma. These cells contain inflammatory enzymes, generate leukotrienes, and express a wide variety of pro-inflammatory cytokines. Increases in eosinophils often correlate with greater asthma severity. In addition, numerous studies show that treating asthma with corticosteroids reduces circulating and airway eosinophils in parallel with clinical improvement. However, the role and contribution of eosinophils to asthma is undergoing a reevaluation based on studies with an anti-IL-5 treatment that has significantly reduced eosinophils but did not affect asthma control. Therefore, although the eosinophil may not be the only primary effector cell in asthma, it likely has a distinct role in different phases of the disease.
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Anti infective Assessment of Dichrostachys cinerea Root Bark, an Ivorian Anti asthmatic Herbal

Anti infective Assessment of Dichrostachys cinerea Root Bark, an Ivorian Anti asthmatic Herbal

antibacterial activity in our study could be due to geographical regions or nature of ground. As a result, it was shown in Sudan that leaves of the plant possessed anti-infective activities [13]. Also, to heal circumcision wounds, Malinkés peoples use calcined aerial parts of the plant, in local applications [6]. According to the findings of Sinon [14], the leaves extracts of this plant would be active on bacterial strains among which, Staphylococus aureus, Streptococcus pyogenes and Pseudomonas aeruginosa. These antibacterial properties would be due to primary compounds of the whole plant, such as tannins [9,15].
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 PHYTOPHARMACOLOGY OF NERIUM OLEANDER L.– A REVIEW

 PHYTOPHARMACOLOGY OF NERIUM OLEANDER L.– A REVIEW

In recent years, the attempts have been made to investigate the drugs against infectious diseases. The Nerium oleander has been widely studied for presence of pharmacological active constituents by the number of recent scientific literature. The compounds like terpenes, steroids, polyphenols and flavanoids has been identified from the various parts of the plant. The phytochemical review on N. oleander has anthologized from the electronic databases viz., SCOPUS, Google Scholar, PubMed, Springer, Elsevier, ACS, Medline Plus and Web of Science. The N. oleander shows the biological activities like antinociceptive, antiinflammatory, antioxidant, anti-asthmatic, anticancer, hepatoprotective and antibacterial, antidiarrhoeal, antimicrobial, diuretic, antileukemic, immunomodulatory, larvicidal, antibacterial, anti-diabetic, antiulcer and molluscicidal activities are supported by the literature.
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Effect of Various Extracts of Tectona grandis Linn. Bark on Bronchitis

Effect of Various Extracts of Tectona grandis Linn. Bark on Bronchitis

Bronchial asthma is a chronic inflammatory disease, characterized by both bronchoconstriction and airway inflammation which leads to bronchial hyper-responsiveness to various stimuli, in which many cell types play a role, more important being mast cells, eosinophils and T- lymphocytes. Various extracts of Tectona grandis Linn. bark were screened for antiasthmatic activity by using different in-vivo animal models like mast cell degranulation and capillary permeability. The results of these studies indicated that ethyl acetate extract of Tectona grandis Linn. bark showed significant (p< 0.001) antiasthmatic activity. The anti-asthmatic activity of ethyl acetate extract can be attributed to mast cell stabilizing and adaptogenic activity suggestive of its potential in management of asthma.
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Journal of Applied Pharmaceutical Science

Journal of Applied Pharmaceutical Science

The present study aimed to evaluate the anti-asthmatic activity of the hydro-alcoholic extract of Citrullus colocynths and Cucumis trigonus (Cucurbitaceae) fruits on Ovalbumin induced Asthma in rats. Extracts were prepared with 70% v/v ethanol using cold maceration followed by Soxhlation. Hydro alcoholic extract (200 and 400 mg/kg) of both fruits were evaluated for anti asthmatic activity on ovalbumin induced Asthma in rats with the help of parameters like, absolute eosinophil count in BALF, total leukocyte count in the BALF, absolute eosinophil count in the Blood, IgE antibodies in serum and histopathological findings of lungs. Both plants were showed significant anti asthmatic activity (p < 0.001) with dose of 200 & 400 mg/kg when compared with disease group. Obtained results were almost similar to that of normal group. With the same dose, C. colocynths was shown better anti asthmatic activity than C. trigonus. Hence, further detailed studies are required to evaluate the efficacy of these plants on anti-asthmatic activity.
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