ANTI-CANCER AGENT
Beyond anticoagulant: Heparin as a potential anti-cancer agent
... classical anti-cancer drugs such as paclitaxel and doxorubicin to target tumor cells, has been obtained by several ...anticancer agent or can complement the treatment in combination with other ...
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Modelling the control of cell proliferation by an anti cancer agent
... In the present paper, the development of a mathematical model which describes the in vitro kinetics of the anti-cancer agent topotecan (TPT) on human osteosarcoma cells is described. Clinical ...
16
Application of 3D QSAR and Docking Studies in Optimization of Perylene di imides as Anti Cancer Agent
... in cancer cells which makes an attractive target for cancer ...the anti-cancer ...for anti cancer activity of Perylene di ...for anti- cancer ...
10
Potential of therapeutic antioxidant compounds from pomegranate as anti cancer agent
... In summary, therapeutic potentials of pomegranate in colon tumorigenesis were due in part to targeting miR-126- regulated pathways, which contributes in the underlying anti-inflammatory mechanisms (43). There has ...
7
Doxycycline Inducible Melanogenic Vaccinia Virus as Theranostic Anti-Cancer Agent
... of cancer facilitates early treat- ment and a better success rate for ...detect cancer cells are currently in development or already in daily clinical ...prostate cancer [2] or the carcinogenic ...
13
Identification of TAX2 peptide as a new unpredicted anti- cancer agent
... an anti-angiogenic ...TSP-1-based anti-angiogenic ...strong anti-angiogenic and anti-neoplasic activities ...CD36-expressing cancer cells [45], ABT-510 targets both tumor cells and the ...
20
Computational Evaluation of Novel Schiff Base Complexes as Anti Dengue and Anti-Cancer Agent
... The synthesized complexes were docked with human DNA topoisomerase I (PDB: 1SC7) and Dengue NS3 protease-helicase (PDB ID: 2VBC) using Auto Dock vina and Discovery studio software.. Th[r] ...
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Original Article Promotion of initial anti-tumor effect via polydopamine modified doxorubicin-loaded electrospun fibrous membranes
... the anti-cancer agent had a stronger killing efficiency to tumor cells in PLLA-DOX/pDA group attributing to the improved cell adhesion and affinity of the scaffold via ...
14
Adjuvant chemotherapy for brain tumors delivered via a novel intra cavity moldable polymer matrix
... Pre-clinical polymer-based drug delivery systems targeting localized brain tumor chemotherapy have predominantly utilized single-agent drug release strategies or those involving only one class of drug (e.g. ...
12
Kinetic modelling of the role of the aldehyde dehydrogenase enzyme and the breast cancer resistance protein in drug resistance and transport
... Parameter estimation was performed using the robust software package F ACSIMILE . Three different curve fittings were conducted for average, low loading and high loading cells. Model simulations have been compared with ...
31
Natural Sources of Tocotrienols: A Note on Absorption
... the cancer associated mutations in cells, and metastasis ...of cancer with minimum toxicity ...potent anti- cancer agent against variety of cancers compared to other isoforms ...
5
Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells
... of cancer cell in vitro and in vivo, with little or no toxic effect on normal cells [17, ...an anti-cancer ...as anti-cancer agents [19, ...
7
Molecular Docking of Benzoylurea Derivatives as Potential Anti-Breast Cancer Agent and Its Admet Profiles
... breast cancer which is the second most common cancer in the ...breast cancer with new cases in 2018 is ...breast cancer deaths by 15% ...against cancer cells and also to drugs that have ...
10
Recent Developments of Caesalpinia Decapetala
... shows anti-TMV, anti-anaphylactic, anti-oxidant, anti-cancer, anti-diarrheal, anti-microbial, anti-pyretic, anti-inflammatory, anti- diabetic ...
6
Bromodomain and extra-terminal domain inhibition modulates the expression of pathologically relevant microRNAs in diffuse large B-cell lymphoma.
... of cancer, miRNAs can intricately and markedly influence individual driver genes and entire signalling pathways crucial to the survival of cancer ...
21
High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors
... Tumors responding to immune checkpoint inhibitors (ICIs) have a higher level of immune infiltrates and/or an Interferon (IFN) signature indicative of a T-cell-inflamed phenotype. Melanoma and lung cancer ...
5
Melatonin: an anti-tumor agent for osteosarcoma
... the anti-tumor effect of melatonin is its ability to induce ...ovarian cancer, it was shown that melatonin causes increasing expression levels of the cleaved caspase 3, Bax, p53, and decreasing expres- sion ...
8
Macrophage targeting contributes to the inhibitory effects of embelin on colitis-associated cancer
... The canonical IKKβ/NF-κB pathway provides the critical mechanistic link between inflammation and cancer [35]. Microbial and viral infections and pro-inflammatory cytokines trigger this pathway through activating ...
11
Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage
... Figure 4: Ruthenium complexes increased the radiosensitivity of pancreatic cancer cells. (A) PANC 1 cells were treated with 500 nmol Ru-SR1# or Ru-SR3# for 24 h and then were exposed to 2, 4 or 6 Gy of X-ray. The ...
11
Synthesis and Biological Evaluation of Some2-Phenyl-4-(Substituted Phenylamines)-Benzo-1,3-Diazine Derivatives with Antimicrobial Activities
... outward through the agar medium producing an antibiotic concentration gradient. The concentration of the antibiotic at the edge of the disk is high and gradually diminishes as the distance from the disk increases to a ...
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