Anti-CD4+
Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice
... of CD4 + immunosuppressive cells in the tumor-bearing host represents another poten- tial anti-tumor therapeutic strategy against ...mice, CD4 depletion with an anti-CD4 depleting ...
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Epitope Mapping of Ibalizumab, a Humanized Anti-CD4 Monoclonal Antibody with Anti-HIV-1 Activity in Infected Patients
... with CD4-IgG2 or PR14 in PBS and then diluted with blocking buffer before it was added to the ...mouse anti-human IgG4 secondary antibodies (Alpha Diagnostic International, San Antonio, ...goat ...
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Preventive effects of early anti-CD4 or anti-CD8 treatment on Borna disease in rats.
... To determine the contribution of different T-cell subsets to the pathogenesis of Borna disease, virus-infected rats were treated with monoclonal antibodies specific for CD4+ and CD8+ cel[r] ...
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Interleukin 6 promotes murine lupus in NZB/NZW F1 mice
... IL-6. Anti-IL-6 alone elicited an anti-rat response that blocked its biologic ...of anti-CD4 concurrent with the first dose of ...of anti-IL-6 ...
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BCG vaccination prevents reactivation of latent lymphatic murine tuberculosis independently of CD4+ T cells
... FIGURE 3 | BCG vaccination prevents reactivation of chronic lymphatic Mtb infection. Sixty days after vaccination with BCG or BCG 1 BCG1419c mice were infected i.d. with 1 × 10 2 Mtb H37Rv. At weekly intervals, mice ...
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Down Regulation of CD4 Expression following Isolation and Culture of Human Monocytes
... monocyte CD4 was down regulated in our ...with anti-CD4–PE MAb prior to culture continued to display a PE signal following overnight culture and ...goat anti-mouse Ig–FITC to these harvested ...
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Mechanisms of immune activation of human immunodeficiency virus in monocytes/macrophages.
... To determine the population of T cells involved, T cells from uninfected donors were treated with anti-CD4 or anti-CD8 antibodies and complement and then added to washed adherent cells f[r] ...
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ts1, a temperature-sensitive mutant of Moloney murine leukemia virus TB, can infect both CD4+ and CD8+ T cells but requires CD4+ T cells in order to cause paralysis and immunodeficiency.
... In some experiments, a specific subset of T cells was depleted in vivo by intraperitoneal administration of 0.5 mg of anti-CD4 for CD4+ T cells or anti-CD8 for CD8+ T cells antibodies on[r] ...
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Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease
... antibodies: anti- CD11c monoclonal (dendritic cells/inflammatory cells) (Abcam, cat ...RT), anti-CD4/CD8 monoclonal antibodies (Novocastra, cat no. NCL-CD4-IF6/cat ...hours), anti-CD68 ...
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Role of CD4 molecule in the induction of interleukin 2 and interleukin 2 receptor in class II major histocompatibility complex restricted antigen specific T helper clones T cell receptor/CD3 complex transmits CD4 dependent and CD4 independent signals
... The CD4 molecule plays an essential role in antigen-induced activation of T helper (Th) cells, but its contribution to signal transduction events resulting in physiologic T cell function is ill ...utilizing ...
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Treatment of encephalomyocarditis virus-induced central nervous system demyelination with monoclonal anti-T-cell antibodies.
... In order to determine the role of CD4+ and CD8+ T-cell subsets in the kinetics of EMC viral clearance, BALB/c mice were treated with 1 mg of either anti-CD4 GK1.5 or anti-CD8 2.43 monocl[r] ...
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Histamine receptor H1 is required for TCR mediated p38 MAPK activation and optimal IFN γ production in mice
... Histamine receptor H 1 (H 1 R) is a susceptibility gene in both experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune orchitis (EAO), 2 classical T cell– mediated models of organ-specific autoimmune ...
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Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation
... with anti-CD3 plus anti-CD28 treatment ...cause CD4 ⫹ T cell activation. (A) Ef- fects of disulfiram and anti-CD3 plus anti-CD28 treatment on the sizes of resting CD4 ⫹ T ...
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IL 12 upregulates TIM 3 expression and induces T cell exhaustion in patients with follicular B cell non Hodgkin lymphoma
... T cells were cultured in OKT3-coated (0.2 μg/ml) plates with anti-CD28 Abs in the presence or absence of a series of doses of IL-12 for 3 days. TIM-3 expression was measured by flow cytom- etry (n = 10). (B) ...
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A Lectin EGF antibody promotes regulatory T cells and attenuates nephrotoxic nephritis via DC SIGN on dendritic cells
... Male 6-8-week old Wistar-Kyoto rats were bred and kept in specific-pathogen-free conditions in an animal facility. Rabbit nephrotoxic serum was generated as described pre- viously [27,28]. The amount of nephrotoxic serum ...
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Functional T-Cell Deficiency in Adolescents Who Experience Serogroup C Meningococcal Disease despite Receiving the Meningococcal Serogroup C Conjugate Vaccine
... controls, CD4 T-cell proliferation rates in response to both anti-CD3 (T-cell receptor [TCR]) stimulation and anti-CD3 in the presence of B cells activated through anti-IgD conjugated to ...
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Pro and Anti-inflammatory Cytokine Production in CD4+ T Lymphocytes in Children with Asthma and Allergic Rhinitis Exposed to the Monocyte Locomotion Inhibitory Factor (MLIF)
... Asthma and allergic rhinitis are characterized by mucosal inflammation, which is hypothesized to be responsible for many of the pathophysiological features of these diseases. CD4+ T lymphocytes are particularly ...
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HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality
... bivalent anti-GITR antibody, naïve CD4+ T cells were stimulated with plate-bound anti-CD3 antibody (1 μg/mL) in the presence of HERA- GITRL or anti-GITR antibody (both 1000 ...the ...
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Anti-glycoprotein D monoclonal antibody protects against herpes simplex virus type 1-induced diseases in mice functionally depleted of selected T-cell subsets or asialo GM1+ cells.
... Incidence of encephalitis in HSV-1-infected BALB/c mice depleted of CD4+, CD8+, or asialo GM1+ cells and treated with anti-gD MAb' Group Cell depletion Anti-gD treatment No.. of deaths/t[r] ...
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Determinants of uncontrolled hypertension among clients on anti-retroviral therapy in Kadoma City, Zimbabwe, 2016
... Having no education, being above 40 years of age, smok- ing, drinking alcohol (sorghum beer, lagers and wines), and adding salt regularly to dishes were socio-demographic risk factors for uncontrolled hypertension among ...
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