Anti-CD40
Immunoliposome co-delivery of bufalin and anti-CD40 antibody adjuvant induces synergetic therapeutic efficacy against melanoma
... of anti-CD40-BFL was superior in a B16 melanoma cell mouse xenograft model, which is consistent with the results of cytotoxicity in ...The anti- CD40 solution had a minimal inhibitory effect ...
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Vascular targeting of anti CD40 antibodies and IL 2 into autochthonous tumors enhances immunotherapy in mice
... engineer anti-CD40 agonist antibod- ies and recombinant IL-2 such that they were selectively delivered into spontaneously arising tumors in a transgenic mouse model of islet cell ...local ...
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Prevention of arthritis by interleukin 10-producing B cells
... that CD40 might have a role in a negative feed- back loop that in this model would lead to the control of Th1 differentiation by B ...and anti-CD40 failed to trigger the differentiation of B cells ...
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Inhibition of IL-13 by Antisense Oligonucleotide Changes Immunoglobulin Isotype Profile in Cultured B-Lymphocytes
... The link between IL-13 and bronchial hyper-responsiveness has brought this cytokine as a potential therapeutic target for asthma and allergic diseases. At the present study, we address the role of B cell derived IL-13 in ...
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Rescue of CD8 T cell–mediated antimicrobial immunity with a nonspecific inflammatory stimulus
... with anti-CD40 at the time of T cell infusion reprograms trans- ferred T cells, allowing them to proliferate and confer protective immunity upon bacterial challenge 7 days ...that CD40-mediated ...
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CD40-CD40 Ligand Pathway Is a Major Component of Acute Neuroinflammation and Contributes to Long-term Cognitive Dysfunction after Sepsis
... if anti-CD40 treatment could improve long-term brain dysfunction in sepsis ...of CD40 sig- naling was able to improve long-term cognitive function in sepsis survivor ...in CD40 signaling ...
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Activated B cells from patients with common variable immunodeficiency proliferate and synthesize immunoglobulin
... hypogammaglobulinemia is caused by an intrinsic B cell defect, we studied B cell function of 22 CVI patients. Cultured B cells from all CVI patients underwent normal proliferation and synthesized normal quantities of IgE ...
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Generation of Immune Responses against Hepatitis C Virus by Dendritic Cells Containing NS5 Protein-Coated Microparticles
... LPS, anti-CD40, and recombinant HCV NS5 induced an anti- gen-specific cellular immune response that was evident in vitro and in ...and anti-CD40 secreted elevated levels of IL-2 and ...
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Sunitinib enhances the antitumor responses of agonistic CD40- antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment
... of anti-CD40 mAb is superior to systemic treatment, and that four days of sunitinib treatment is sufficient to induce chemokine expression in ...Therefore, anti-CD40 mAb therapy was ...
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Latent Membrane Protein 1 as a molecular adjuvant for single cycle lentiviral vaccines
... with anti-CD40, anti-CD80, anti-CD83, anti- CD86, anti-CD11c or anti-HLA-DR or anti-CCR7 in fluorescence-activated cell sorter buffer (PBS supple- mented with 3% ...
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Do CD40L and CD40 contribute to sickle cell anemia?
... an anti-CD40L antibody improved the overall health of the SCA ...into CD40 knockout mice, followed by treatment with an anti-CD40 antibody, decreased lung pathology when compared to mice ...
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Malaysian endophytic fungal extracts induced anti inflammation in Lipopolysaccharide activated BV 2 microglia is associated with attenuation of NO production and, IL 6 and TNF α expression
... BV2 microglia cells were seeded in a 12-well plate at a seeding density of 2 × 10 5 cells per well, incubated for 24 h and then treated with endophytic extracts at 0.1 mg/mL (extracts exhibited not more than 30 % cell ...
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Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L
... with anti-CD40 antibody or CD40 siRNA significantly attenuated cytokine production and activation of signal molecules in the co-culture system, but did not completely ...that anti-TNFR1 ...
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Aged B lymphocytes retain their ability to express surface markers but are dysfunctional in their proliferative capability during early activation events
... Another early sign of B cell activation is the formation of blast cells. Splenocytes from young and aged QM mice were cultured for 24 and 48 hrs with media only, LPS, or anti-CD40 mAb as above. Analysis of ...
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Anti T cell immunoglobulin and mucin domain 2 monoclonal antibody exacerbates collagen induced arthritis by stimulating B cells
... A previous study by Chen et al. indicated that Sema4A-Ig fusion protein does not bind to the TIM-2- transfectants [4]. Consistent with this report, we have been unable to confirm the binding of Sema4A and TIM-2 (data not ...
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The MS risk allele of CD40 is associated with reduced cell-membrane bound expression in antigen presenting cells: implications for gene function
... molecule CD40 in the development of multiple sclerosis ...the CD40 genetic variant(s) associated with MS, ...on CD40 expression at the mRNA and protein ...which CD40 is most highly expressed, ...
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Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis
... of CD40 protein were observed in both the plasma [9] and the cell sur- face of skin fibroblasts [10] from SSc ...of CD40 polymorphisms with susceptibility to a number of auto- immune diseases, such as GD ...
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Hojer, Caroline (2009): Mechanisms of B cell activation and lymphomagenesis. Dissertation, LMU München: Fakultät für Biologie
... of CD40. To set a link between LMP1/CD40 and CD19, we analyzed the phosphorylation status of the PTK ...that CD40 activation of B cells leads to the phosphorylation of the PTKs Lyn, Fyn and Syk (Ren ...
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miR 145 mediated the role of aspirin in resisting VSMCs proliferation and anti inflammation through CD40
... 200 nM of the miR-145 inhibitor or the miR-145 inhibi- tor control by using the Sofast transfection reagent (Xia- men, China) according to the manufacturer’s instruction. Total RNA and protein were extracted from VSMCs ...
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Comparative Analysis of Signal Transduction by CD40 and the Epstein-Barr Virus Oncoprotein LMP1 In Vivo
... sections were incubated with horseradish peroxidase (HRP)-conjugated peanut agglutinin (PNA; 25 g/ml; Sigma Chemical Co., St. Louis, Mo.) and biotinylated rat anti-mouse B220 (clone RA3-6B2; BD Pharmingen). ...
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