ANTIFUNGAL DRUG
Nationwide Study of Candidemia, Antifungal Use, and Antifungal Drug Resistance in Iceland, 2000 to 2011
... Candidemia is often a life-threatening infection, with highly variable incidence among countries. We conducted a nationwide study of candidemia in Iceland from 2000 to 2011, in order to determine recent trends in ...
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A Novel Sterol-Signaling Pathway Governs Azole Antifungal Drug Resistance and Hypoxic Gene Repression in Saccharomyces cerevisiae
... azole drug treatment and ...relevant antifungal drugs ketoconazole and ...azole drug resistance, indicating that SET domain proteins govern antifungal drug ...azole drug efficacy ...
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Antagonism between Two Mechanisms of Antifungal Drug Resistance
... because the number of potential interactions will increase geo- metrically with the number of mechanisms. The genes of al- tered expression identified here can serve as candidates for measuring their contribution to the ...
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In vitro and in silico analysis of the effect of fluconazole, an antifungal drug, on DNA
... important antifungal drug used worldwide for the treatment of peritonitis and cryptococcal meningitis, urinary tract infections, esophageal tract infections and vaginal ...
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Haploidy, Diploidy and Evolution of Antifungal Drug Resistance in Saccharomyces cerevisiae
... drashov 1993), hinge on the ability of populations (a) Two factors are preeminent in determining the effect to cope with deleterious mutation (Kondrashov and of ploidy on the rate of adaptation (Orr and Otto 1994): Crow ...
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Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway
... and drug resistance to current antifungals, there is an urgent need to discover novel leads from molecules of natural origin especially those derived from plants and microorgan- isms for antifungal ...
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Antifungal Drug Susceptibility and Phylogenetic Diversity among Cryptococcus Isolates from Dogs and Cats in North America
... each antifungal drug tested between two groups were compared using a Mann-Whit- ney test, with a null hypothesis that there were no differences between the ...of antifungal drug therapy versus ...
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Mode of Selection and Experimental Evolution of Antifungal Drug Resistance in Saccharomyces cerevisiae
... We show that mode of selection, degree of dominance of mutations, and ploidy are determining factors in the evolution of resistance to the antifungal drug fluconazole in yeast. In experiment 1, yeast ...
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A study on biofilm production and antifungal drug resistance among Candida species from vulvovaginal and bloodstream infections
... and antifungal drug resistance were observed more in ...candidiasis. Antifungal drug resistance was more commonly seen with ...and antifungal susceptibility become necessary to reduce ...
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High Throughput Nano Biofilm Microarray for Antifungal Drug Discovery
... and drug resis- tance characteristics of the nano-biofilms on the microarray are comparable to those of the macroscopic biofilms formed in 96- well ...novel antifungal drug candidates or novel com- ...
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ABC and MFS Transporters: A reason for Antifungal drug resistance
... A. fumigatus genome comprises of 49 ABC transporters, however there is not much evidence available to link any ABC transporter with clinically relevant antifungal drug resistance. The probable reason behind ...
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Evaluation of Lysine Biosynthesis as an Antifungal Drug Target: Biochemical Characterization of Aspergillus fumigatus Homocitrate Synthase and Virulence Studies
... Aspergillus fumigatus is the main cause of severe invasive aspergillosis. To combat this life-threatening infection, only limited numbers of antifungals are available. The fungal ␣ -aminoadipate pathway, which is ...
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Role of DNA Mismatch Repair and Double-Strand Break Repair in Genome Stability and Antifungal Drug Resistance in Candida albicans
... Loss of MMR (msh2 ⌬ /msh2 ⌬ and pms1 ⌬ /pms1 ⌬ mutants) or loss of DSBR (rad50 ⌬ /rad50 ⌬ ) leads to an increase in flu- conazole-resistant colonies, as shown in Fig. 6. Colonies of these strains appear within the ...
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Rad53 and Chk1 Dependent DNA Damage Response Pathways Cooperatively Promote Fungal Pathogenesis and Modulate Antifungal Drug Susceptibility
... IMPORTANCE Genome instability is detrimental for living things because it induces genetic disorder diseases and transfers incorrect genome information to descen- dants. Therefore, living organisms have evolutionarily ...
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FORMULATION AND EVALUATION OF BIOADHESIVE MATRIX TABLET OF AN ANTIFUNGAL DRUG
... an Antifungal drug ( Azoles, Imidazole derivative) mainly Externally – Athlete‟s foot, Ring worm, Jock itch, Internally – Oral or Vaginal thrush (yeast infection) caused by ...
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Comparison of a New Colorimetric Assay with the NCCLS Broth Microdilution Method (M 27A) for Antifungal Drug MIC Determination
... of antifungal drug ...of antifungal agents began in 1982 with the establishment of the National Committee for Clinical Laboratory Standards (NCCLS) Subcommittee for Antifungal Susceptibility ...
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Essential Gene Discovery in the Basidiomycete Cryptococcus neoformans for Antifungal Drug Target Prioritization
... for antifungal drug prioritiza- ...a drug target with these features is the protein Fks1, which is the catalytic sub- unit of 1,3-beta- D -glucan synthase and is targeted by the echino- ...rational ...
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Conserved Fungal Genes as Potential Targets for Broad-Spectrum Antifungal Drug Discovery
... Identification of conserved fungal genes via concordance analysis. It is generally believed in the antimicrobial drug dis- covery community that conserved, essential genes have great potential to yield ...
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Use of Turbidimetric Growth Curves for Early Determination of Antifungal Drug Resistance of Filamentous Fungi
... all drug concentrations that showed more than 50% growth for IT and TB and more than 75% growth for AB after the recommended incubation ...the drug-free control, we were able to infer conclu- sions about ...
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“Design, Development and Evaluation of Proniosomal Gel of an Antifungal Drug-Ketoconazole” by Gagandeep Benipal, India.
... of drug in optimized formulation (F3) containing Span 60 is high ...of drug permeation through the membrane from the optimized formula was also quite high ...of drug at site of action and overcoming ...
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