Antigen challenge
Influx of kininogens into nasal secretions after antigen challenge of allergic individuals
... after antigen challenge were not different from base ...during antigen titration experiments and between the time courses of appearance and disappearance of HMWK, TK, kinin, and albumin after ...
8
The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose
... three antigen challenges, one of the most com- mon allergen models utilised in studies using Penh, resulted in hyperresponsiveness that was confined prima- rily to the tissue compartment of the ...
10
Endogenous cortisol regulates immunoglobulin E dependent late phase reactions
... To investigate the impact that physiological variation in serum cortisol has on IgE-mediated events, 10 atopic subjects underwent cutaneous antigen challenge with measurement of the early phase wheal (EPW) ...
9
Characterisation of the kinin receptor in the human nasal airway and its role in allergic rhinitis
... nasal challenge with grass antigen, in sensitive subjects, the concentration of substance P, CGRP and VIP in the nasal lavage fluid is raised (Mosimann et ...Nasal challenge with histamine raises the ...
232
Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMα) in chronic hypoxia- and antigen-mediated pulmonary vascular remodeling
... standard antigen-challenge model normally used to examine inflammatory ...extended antigen challenges with either ovalbumin (Ova) or Aspergillus fumigatus antigen (Asp ag) lacking any viable ...
16
Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways
... multiple antigen challenge when compared with saline controls and there was no effect of dexamethasone treatment on basal P enh at the doses ...tested. Antigen challenge significantly ...
6
Lymph node trafficking and antigen presentation by endobronchial eosinophils
... aerosol antigen challenge to process and present antigen to which they were exposed with- in the ...exogenous antigen, confirming the absence of contaminating APCs among the purified T ...
10
Failure of Hypoxic Pulmonary Vasoconstriction in the Canine Asthma Model: EFFECT OF PROSTAGLANDIN INHIBITORS
... after antigen challenge in the responders not given aspirin or indomethacin, but increased significantly and was associated with a lesser degree of arterial hypoxemia in the responders pretreated with ...
9
Neuronal Circuits Modulate Antigen Flow Through Lymph Nodes
... an antigen challenge in immunized animals can lead to a reduction in muscle contractions, resulting in restriction of lymphatic flow and antigen trafficking, these effects require chronic exposure to ...
11
Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation
... after antigen challenge in a mouse model of eosinophilic airway inflammation in which mice were sensitized to chicken ovalbumin (OVA) and then challenged with aerosolized OVA ...the challenge, ...
10
Viral acute lower respiratory infections impair CD8+ T cells through PD 1
... Viral antigen was sufficient for PD-1 upregulation, but induction of PD-L1 was required for ...epitope-only challenge, memory T CD8 rapidly reexpressed PD-1 and exhibited severe functional ...
17
A DNA Vaccine That Targets Hemagglutinin to Antigen-Presenting Cells Protects Mice against H7 Influenza
... targeting antigen to APCs, particularly when the aim is to induce rapid immune responses to limit the outbreak of pandemic ...H7 antigen alone was able to induce modest IgG titers over ...lethal ...
13
Immunization with a Pseudomonas aeruginosa 1244 Pilin Provides O-Antigen-Specific Protection
... In current chemically cross-linked glycoconjugate vaccines, two purification steps must be performed, including isolation of an appropriate carrier protein, in addition to refinement of the bacterial surface ...
8
Spotlight on the diagnosis of extrinsic allergic alveolitis (hypersensitivity pneumonitis)
... be performed by well-experienced physicians. If done correctly it is a very sensitive and specific diagnostic method. See Table 2 and example in Figures. 1D, methodological methods have been published elsewhere [14,15], ...
6
Recent Developments in the Nasal Immunization against Anthrax
... an antigen to synthetic microparticles has been known for many years and has been previously reviewed in de- tail ...major challenge due to unfavour- able physiological ...including antigen ...
13
Analysis of Trichosporon Isolates Obtained from the Houses of Patients with Summer Type Hypersensitivity Pneumonitis
... Patients with SHP had positive reactions to inhalation chal- lenge with antigens of the same serotype of T. cutaneum that had been isolated from their houses, indicating that patients are typically sensitized by exposure ...
5
Vaccination with a Fusion Protein That Introduces HIV-1 Gag Antigen into a Multitrimer CD40L Construct Results in Enhanced CD8+ T Cell Responses and Protection from Viral Challenge by Vaccinia-Gag
... studies, antigen and multitrimer CD40L adjuvant were used as separate molecules and mixed together for immunization ...incorporated antigen (exemplified by HIV-1 Gag) and multitrimer CD40L into a single ...
10
General Strategy for Decoration of Enveloped Viruses with Functionally Active Lipid-Modified Cytokines
... Viral particles preferentially incorporate extra- and intracellular constituents of host cell lipid rafts, a phenomenon central to pseudotyping. Based on this mechanism, we have developed a system for the predictable ...
11
Vaccination with the Conserved Caveolin-1 Binding Motif in Human Immunodeficiency Virus Type 1 Glycoprotein gp41 Delays the Onset of Viral Infection and Provides Partial Protection in Simian/Human Immunodeficiency Virus-Challenged Cynomolgus Macaques
... challenge (25, 26), while H2 and H5 class IB are associated with susceptibility to infection (27). H1 was also previously reported to be enriched in, but not exclusive to, monkeys that control SIV (46, 47). In the ...
16
Characterization of a Therapeutic Model of Inhalational Anthrax Using an Increase in Body Temperature in New Zealand White Rabbits as a Trigger for Treatment
... Aerosol challenge. A modified Microbiological Research Establish- ment-type three-jet collision nebulizer (BGI, Waltham, MA) with a pre- cious fluid jar was used to generate a controlled delivery of aerosolized B. ...
9