Antigen receptor
A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer
... chimeric antigen receptor recognizing the same tumor ...chimeric antigen receptor used in our studies is comprised of T cell intracellular signaling domains, derived from CD3ζ and CD28, linked ...
17
Antigen receptor signaling in the rheumatic diseases
... for antigen recognition (Figure ...of antigen receptor ...complement receptor-2) that interacts with the Lyn SFK plays a similar coreceptor role on B ...
9
Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
... Chimeric antigen receptor (CAR) T cells have been highly successful in treating hematological malignancies, including acute and chronic lymphoblastic ...
14
Chimeric antigen receptor T cell therapies for multiple myeloma
... mature antigen; BsAb: Bispecific antibody; CARs: Chimeric antigen receptors; CAR-T: Chimeric antigen receptor-modified T cells; CD: Cluster of differentiation; CLL: Chronic lymphocytic ...
12
CHIMERIC ANTIGEN RECEPTOR FOR CHRONIC LYMPHOCYTIC LEUKEMIA A REVIEW
... Chronic lymphocytic leukemia (CLL) cancer is a deadly one which affects the bone marrow from making it to produce more amounts of white blood cells in the humans [66,67,73]. The lymphocytes consist of natural killer ...
6
Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
... carcinoembryonic antigen (CEA), mesothelin (MSLN), and Interleukin 13 receptor, Alpha2 (IL13Rα2) ...same antigen have demonstrated different on-target, off-tumor toxicities in preclinical trials, ...
10
Structure and function of the T cell antigen receptor
... This has been further supported by more recent experiments in which a heterologous receptor that activates the inositol phospholipid pathway, the human muscarinic receptor subtype 1, whe[r] ...
9
Antigen receptor genes as molecular markers of lymphoid neoplasms
... The normal Bcl-2 gene is highly transcribed at a pre-B cell stage of development when this translocation occurs.. The RNA remains elevated in t 14; 18 bearing mature B cell neoplasms in [r] ...
6
<p>Coexistence Of A Huge Venous Thromboembolism And Bleeding Tendency In Cytokine Release Syndrome During CAR-T Therapy</p>
... Abstract: Chimeric antigen receptor (CAR)-modi fi ed T cell therapy is increasingly adminis- tered for hematological malignancies. Cytokine release syndrome (CRS) is a common and severe complication of CAR-T ...
6
CAR-T “the living drugs”, immune checkpoint inhibitors, and precision medicine: a new era of cancer therapy
... Monoclonal antibodies (MoAb) targeting CD20 with rituxi- mab, ofatumumab, and obinutumumab have led to a para- digm shift in B cell lymphoma and leukemia therapy [1, 2]. MoAbs targeting HER2 are widely used for breast ...
5
Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors
... chimeric antigen receptor which uses a DARPin for its antigen recognition domain, we exchanged the scFv domain of a second generation CAR with specifi- city against HER2 [20] (herein referred to as ...
11
Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance?
... These receptor families reflect the two major (CC and CXC) chemokine families and two minor (C and CX 3 C) chemokine families ...Duffy antigen receptor for chemokines (DARC), D6 (also known as CC ...
11
Combination systemic therapies with immune checkpoint inhibitors in pancreatic cancer: overcoming resistance to single-agent checkpoint blockade
... TNF receptor (GITR), and CD40), adoptive T-cell therapies and chi- meric antigen receptor (CAR) T-cells, chemotherapy, RT, and targeted therapies as candidate agents for com- bination in this ...
16
Investigation of serine kinase signalling networks in T lymphocytes
... serine/threonine have not been very useful because high basal levels of serine and threonine phosphorylation make it difficult to distinguish basal serine phosphorylations from extracellular signal regulated events. It ...
208
Detection of monoclonal immunoglobulin heavy chain gene rearrangement (FR3) in Thai malignant lymphoma by High Resolution Melting curve analysis
... of antigen receptor gene rearrangement including T cell receptor (TCR) and immunoglobulin heavy chain (IgH) by polymerase chain reaction followed by heteroduplex has currently become standard whereas ...
9
CRISPR-Cas, a robust gene-editing technology in the era of modern cancer immunotherapy
... Cancer immunotherapy has been emerged as a promising strategy for treatment of a broad spectrum of malig- nancies ranging from hematological to solid tumors. One of the principal approaches of cancer immunotherapy is ...
17
From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma
... chimeric antigen receptor-modified T cells (CAR-T) or genetically modified NK cells, has been shown to be a promising strategy for the treatment of ...
21
Cancer biomarkers for targeted therapy
... Tumor-associated antigens (TAA) or cancer biomarkers are major targets for cancer therapies. Antibody- based agents targeting the cancer biomarkers include monoclonal antibodies (MoAbs), radiolabeled MoAbs, bispecific T ...
7
Regulatory T cells in multiple sclerosis and myasthenia gravis
... A recent analysis of over 14,000 MS patients using ImmunoChip genotyping found abnormalities in genes in- volved in Treg IL-2 signaling, CD25, and CD127 [55]. While CD127 is expressed highly on Teff, but minimally on ...
16
Interaction of HLA DRB1*1501 and TNF Alpha in a Population based Case control Study of Multiple Sclerosis
... leukocyte antigen (HLA), T cell receptor beta (TCA receptor β), tumor necrosis factor α (TNF α), tumor necrosis factor β (TNF β), apolipoprotein E (APOE), interleukin 7 receptor alpha chain ...
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