antigenic site
Subtype and antigenic site specific differences in biophysical influences on evolution of influenza virus hemagglutinin
... HA antigenic sites compared to non-antigenic site residues, and for all but the Sa antigenic site of H1 ...this antigenic site between the pandemic “Swine-origin” H1N1 ...
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Amino Acids in Hemagglutinin Antigenic Site B Determine Antigenic and Receptor Binding Differences between A(H3N2)v and Ancestral Seasonal H3N2 Influenza Viruses
... the antigenic difference between circulating H3N2 and the swine-origin viruses and the need to evaluate and approve A(H3N2)v ...the antigenic phenotype impact both receptor specificity and antibody ...in ...
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Immunodominance of Antigenic Site B in the Hemagglutinin of the Current H3N2 Influenza Virus in Humans and Mice
... distinct antigenic sites in the head domain of H3 hemagglutinin, A to E, have been previously described by mapping the binding sites of monoclonal antibodies, yet little is known about the contribution of each ...
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A Similar Pattern of Interaction for Different Antibodies with a Major Antigenic Site of Foot-and-Mouth Disease Virus: Implications for Intratypic Antigenic Variation
... intratypic antigenic di- versity of ...on antigenic site A of FMDV of serotype C (32) showed distinct degrees of conservation during the natural evolution of the virus in the ...of antigenic ...
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A subgroup-specific antigenic site in the G protein of respiratory syncytial virus forms a disulfide-bonded loop.
... 5143 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest An antigenic site represented by 15 amino acids, residues 174 to 188, designated peptide 12 of the large glycoprote[r] ...
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Identification of a T-cell epitope adjacent to neutralization antigenic site 1 of poliovirus type 1.
... Immunization of BALB/c H-2d mice with the uncoupled p86-115 peptide, which represents VP1 amino acids 86 to 115 and contains both the T-cell epitope and the C3 neutralization epitope, in[r] ...
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Antigenic site II of the rabies virus glycoprotein: structure and role in viral virulence.
... Mutations conferring resistance to neutralization by site II-specific monoclonal antibodies were localized into two clusters, the first between amino acids 34 and 42 seven groups of muta[r] ...
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Fine mapping of antigenic site II of herpes simplex virus glycoprotein D.
... To determine which continuous epitopes are immunogenic in the native protein, synthetic peptides mimicking many regions of gD were screened with polyclonal sera prepared against purified[r] ...
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Variations among gamma globulins at the antigenic site revealed by pepsin digestion
... Deficiency of IgG myeloma proteins for the pepsin site occurred in all M-components of the Ge or Ne H-chain subgroup; universal deficiency was not a feature of the Vi myelomas tested, si[r] ...
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Construction of a poliovirus type 1/type 2 antigenic hybrid by manipulation of neutralization antigenic site II.
... A number of groups have described the construction of antigenic hybrids of poliovirus in which part of N-AgI, the BC loop of VP1, of PV-1M 11, 15, 16 or PV-1S 1 has been replaced with th[r] ...
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Mutations in or near the fusion peptide of the influenza virus hemagglutinin affect an antigenic site in the globular region.
... In the case of Y8-10C2, variant analysis performed with native HA could be correlated with variant analysis performed with alternative forms of the protein, including denatured protein 2[r] ...
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Mapping of a neutralizing antigenic site of Coxsackievirus B4 by construction of an antigen chimera.
... This chimera, designated CVB3/4, was constructed by inserting five amino acids of the putative BC loop of the structural protein VP1 of CVB4 into the corresponding loop of CVB3 by site-d[r] ...
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Neutralizing monoclonal antibodies to hepatitis A virus: partial localization of a neutralizing antigenic site.
... The monoclonal antibodies used in cross-linking experiments, immune precipitations of labeled HAV, and other experiments to identify the neutralizing sites on the virus were purified fro[r] ...
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Functional and Structural Characterization of Neutralizing Epitopes of Measles Virus Hemagglutinin Protein
... the antigenic site vi, which is unrelated to receptor binding but prob- ably involved in the formation of a higher-order H-F protein oli- gomeric structure (34, 36, 49), is a major neutralizing epitope that ...
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Antigenic Drift Defines a New D4 Subgenotype of Measles Virus
... major antigenic sites in MeV-H, we identified a D4 genotype variant that escapes neutralization by MAbs targeting the neutralizing epitope (NE) antigenic ...By site-directed mutagenesis, L249P was ...
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Genetic Basis for Immunological Aberrations in Poliovirus Sabin Serotype 3 Strains Imported in The Netherlands
... both antigenic sites mutations that resulted in codon changes occurred (Table ...In antigenic site 3B, the six virus strains which could not be neutralized by MAb 33 showed an amino acid substitution ...
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Novel Human Monoclonal Antibody Combination Effectively Neutralizing Natural Rabies Virus Variants and Individual In Vitro Escape Mutants
... recognized antigenic site I, which is highly conserved among a large panel of street RVs, most likely due to the structural constraints of this region of the ...different antigenic site. Our ...
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Distinct repertoire of antigenic variants of foot-and-mouth disease virus in the presence or absence of immune selection.
... Amino acid replacements within antigenic site A of FMDV C-S8cl upon passage of the virus in the absence substitutions indicated above VP1 residues 133 to 156 of C-S8cl or in the presence[r] ...
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First peptide vaccine providing protection against viral infection in the target animal: studies of canine parvovirus in dogs.
... Core of amino acid sequence of antigenic site bound by antibodies in neutralizing sera from dogs vaccinated with the synthetic vaccine and from previously described 27 naturally infected[r] ...
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Marked differences in the antigenic structure of human respiratory syncytial virus F and G glycoproteins.
... The variants selected with 47F antibody lost the capacity to bind only the antibodies that mapped in the same antigenic site, whereas viruses resistant to 63G antibody lost the binding o[r] ...
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