Antineoplastic agents selected by using QSAR technique
Rational drug design of antineoplastic agents using 3D QSAR, cheminformatic, and virtual screening approaches
... Typically, target prediction methods work via molecular similarity. For a given target, the set of molecules experimentally known to bind to it are encoded using descriptors, and used as training data to build up ...
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QSAR analysis of benzophenone derivatives as antimalarial agents
... obtained using the program QikProp and are summarized in Table 1. For the QSAR studies by multiple linear regression (MLR) analysis method, the descriptors were selected based on the results of the ...
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DETERMINATION AND ASSAY OF SOME ANTINEOPLASTIC AGENTS IN PURE FORM AND IN THEIR PHARMACEUTICAL PREPARATIONS USING TITRIMETRIC METHOD
... KEYWORDS: Antineoplastic agents, titrimetric method, Capecitabine, ...INTRODUCTION Antineoplastic chemotherapy is an important component of small animal practice and is routinely used for ...
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2D QSAR Study of Imidazothiazole Propenones Derivatives as Potential Anticancer Agents by DFT QSAR Models
... Lafridi Hind et al. Figure 7: VIF values of the ten descriptors As can be seen from Figure 7, the VIF values of all ten descriptors are smaller than 5.0, indicating that there is no collinearity among the selected ...
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Implementing Security in Mobile Agents by using AES Technique
... cryptography technique (AES) has been selected for providing ...cryptography technique, the application has been made more secure because in order to crack the code, AES key is needed which is ...
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2D QSAR ANALYSIS OF PHTHALIMIDE DERIVATIVES AS POTENT HYPOGLYCEMIC AGENTS
... in selected series were sketched and optimized using V life sciences and were then loaded into a data table within the graphic based QSAR program V life sciences molecular modeling ...
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2D QSAR Study of a Series of Pyrazoline Based Anti Tubercular Agents Using Genetic Function Approximation
... were selected initially for correlation with anti-tubercular ...set using GFA methodology. In- itially, 100 2D-QSAR equations with six descriptors were ...
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QSAR study of 5,6 bicyclic heterocycles analogues as anti Alzheimer’s agents using the statistical analysis methods
... CONCLUSION In this study, three different modelling methods, MLR, MNLR and ANN were used in the construction of a QSAR model for the anti-Alzheimer agents and the resulting models were compared. It was ...
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3D-QSAR CoMFA study of some heteroarylpyrroles as possible anticandida agents
... performed using SYBYL ...constructed using a grid having a spacing of ...the selected compounds were available (for example, atomic coordinates derived from X-ray crystallographic studies of their ...
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QSAR analysis of novel N alkyl substituted isatins derivatives as anticancer agents
... of QSAR models using ...method, using random selection. In the generation of QSAR model we have selected six test and fourteen training ...
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3D-QSAR analysis of pyrimidine derivatives as AXL kinase inhibitors as anticancer agents
... chemotherapeutic agents and reduces the antitumor immune ...compounds using the 3D-QSAR technique. In this technique, pyrimidine derivatives and their inhibitory activity against AXL ...
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SYNTHESIS, SCREENING AND QSAR ANALYSIS OF CHALCONE DERIVATIVES AS POTENTIAL ANTI BACTERIAL AGENTS
... which is defined as the lowest concentration of the compound that completely inhibited the growth of each strain after overnight incubation. MIC was determined using serial tube dilution technique. In this ...
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Quinazoline Derivatives as Anticancer Agents: QSAR, Molecular Docking and in silico Pharmacokinetic Prediction
... Context: Molecular target specific treatment for the cancer is different from the conventional chemotherapy and radiotherapy in terms of selectivity and specificity towards the cancer cells. Amongst the different ...
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Pyrimidinedione: Pharmacophore Optimization of Selective Thymidine Monophosphate Kinase inhibitors using Group QSAR Studies as Potential Antitubercular agents
... EXPERIMENTAL SECTION Biological data Twenty five molecules, reported for their anti-tubercular effect [11] were selected for the present study. The structures of the compounds and their anti-tubercular activity ...
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DFT-based QSAR Studies of cytotoxicity of phenothiazine derivatives as in vitro anti-cancer agents using the statistical analysis methods
... CONCLUSION In this study, three different modelling methods, MLR, MNLR and ANN were used in the construction of a QSAR model for the anti-cancer agents and the resulting models were compared. It was shown ...
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Modeling of Quinoacridinium Derivatives as Antitumor Agents using a QSAR analysis
... The QSAR analysis aims to find an empirically consistent relationship between the molecular properties and the biological activity of a series of homologous structural compounds of the ...The QSAR study ...
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Antineoplastic Agents and (In)fertility: Informing Patients to Improve Decisions
... For Peer Review Only/Not for Distribution 1. Introduction Infertility is a potential adverse effect of antineoplastic cancer therapy. The degree of gonadal toxicity from chemotherapy is influenced by several ...
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Exploration of QSAR: Oxadiazole derivatives as antimicrobial agents
... ______________________________________________________________________________ ABSTRACT A quantitative structure activity relationship study on a series of 2, 5-(substituted) 1, 3, 4- oxadiazole analogues was made ...
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Approval of antineoplastic agents in India: comparison with the US and EU regions
... The antineoplastic drugs are prescribed for the treatment of cancer, which is an important cause of mortality in India; therefore, a drug lag in the availability of antineoplastic drugs is a direct threat ...
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A Review of Prior Authorization Programs: Antihemophilic, Antineoplastic, and Antiretroviral Agents
... procedural requirements for prescribing medications to treat chronic, life-threatening conditions may result in unintended morbidity or mortality. Hemophilia, cancer, and HIV/AIDS are life-threatening illnesses requiring ...
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